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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (13): 1215-1219. 上一篇    下一篇

研究论文

外显子周期三行为特征的研究

田元新1，陈超2，邹小勇*ac，邱建丁2，蔡沛祥1，莫金垣1   

  1. (1中山大学化学与化学工程学院 广州 510275)
    (2萍乡高等专科学校化工系 萍乡 337055)
    (3湖南大学化学生物传感与计量学国家重点实验室 长沙 410082)
  • 投稿日期:2004-08-02 修回日期:2005-03-09 发布日期:2010-12-10
  • 通讯作者: 邹小勇

Study on Period-3 Behavior of Exons

TIAN Yuan-Xin1, CHEN Chao2, ZOU Xiao-Yong*a c, QIU Jian-Ding2, CAI Pei-Xiang1, MO Jin-Yuan1   

  1. (1 School of Chemistry and Chemical Engineering, Sun Yet-Sen University, Guangzhou 510275)
    (2 Department of Chemical Engineering, Pingxiang College, Pingxiang 337055)
    (3 State Key Laboratory of Chem-Biosensing and Chemometrics, Hunan University, Changsha 410082)
  • Received:2004-08-02 Revised:2005-03-09 Published:2010-12-10

PDF

1597

被引次数

58 | 9

基因中蛋白质的编码区具有周期三行为这一规律已成为目前基因预测的理论基础, 采用功率谱对外显子的周期三行为特征进行了研究, 结果表明: 大多数外显子独立存在于基因中时并不具有周期三行为, 而当基因被剪切后外显子连在一起编码蛋白质的时候才具有周期三行为. 并且这种行为特征与外显子的长度、碱基在密码子三个位置上的分布以及氨基酸密码子的使用偏好均有密切关系, 同时符合蛋白质翻译次序的外显子也具有对密码子使用的偏好性, 这一研究结果对于提高基因预测的准确率以及内含子功能的研究具有重要意义.

关键词: 功率谱, 外显子, 编码区, 周期性

It is well-known that base sequences in the protein-coding regions of DNA molecules exhibit a period-3 behavior, which is the theoretical basis of gene prediction. In this work, period-3 behavior of the exons was studied by power spectrum, and the results showed that many exons had no period-3 behavior. After these exons in gene were connected to code proteins, the long coding-protein sequences then displayed the period-3 behavior. The period-3 behavior is related to the distribution of bases and the synonymous codons usage. Each exon was adjusted to make it accord with the translation order, and it has been found that the synonymous codon usage preference is another character of exons. These conclusions would be sig- nificant to gene prediction and the study on introns.

Key words: power spectrum, exon, protein-coding region, periodicity