化学学报 ›› 2006, Vol. 64 ›› Issue (2): 169-174. 上一篇    下一篇

研究论文

利用甘露醇骨架和Pauson-Khand反应合成光学纯的C2轴对称性多环酮类结构

姚祝军   

  1. 有机所
  • 投稿日期:2005-08-04 修回日期:2005-09-22 发布日期:2006-01-28
  • 通讯作者: 姚祝军

Pauson-Khand Approach towards Enantiopure C2-Symmetric Polycyclic Compound from D-Mannitol

  • Received:2005-08-04 Revised:2005-09-22 Published:2006-01-28

以D-甘露醇转化得到的骨架为支架经Pauson-Khand 反应成功实现了高度区域和立体选择性地合成具有C2对称性的多官能团的多环手性化合物1的方法,并采用核磁共振和X-单晶衍射等分析方法对化合物1的结构进行了讨论。

关键词: Pauson-Khand反应, 区域选择性, 立体选择性, C2对称性, 多环化合物

The enantiopure C2-symmetric polycyclic compound 1 with multiple functional groups was synthesized efficiently using a two-directional regio- and stereoselective intramolecular Pauson-Khand reaction upon the precursor derived from D-mannitol. The full target structure was established and confirmed by the corresponding NMR and X-ray crystallography studies.

Key words: Pauson-Khand reaction, regioselectivity, stereoslectivity, C2-symmetry, polycyclic compound