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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (2): 234-238. 上一篇    下一篇

研究论文

3-甲基-4-氨基-1,2,4-三唑-5-硫酮席夫碱的合成及生物活性研究

孙晓红*,1，陶燕1，刘源发2，贾婴琦2，陈邦2   

  1. (1西北大学化工学院化学研究所 西安 710069)
    (2西北大学化学系 西安 710069)
  • 投稿日期:2007-01-30 修回日期:2007-05-21 发布日期:2008-01-28
  • 通讯作者: 孙晓红

Synthesis and Biological Activities of 4,5-Dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione Schiff Bases

SUN Xiao-Hong*,1 TAO Yan1 LIU Yuan-Fa2 JIA Ying-Qi2 CHEN Bang2   

  1. (1 College of Chemical Engineering, Chemical Research Institute, Northwest University, Xi′an 710069)
    (2 Department of Chemistry, Northwest University, Xi′an 710069)
  • Received:2007-01-30 Revised:2007-05-21 Published:2008-01-28
  • Contact: SUN Xiao-Hong

PDF

1137

被引次数

45

用自制的二氨基硫脲与乙酸反应得到3-甲基-4-氨基-1,2,4-三唑-5-硫酮, 然后以醋酸为反应溶剂和催化剂, 使之与取代芳香醛反应, 合成了8个三唑类席夫碱化合物. 通过1H NMR, IR和元素分析对所有化合物进行了结构表征. 并对这些化合物进行了初步生物活性测试, 结果表明大部分化合物具有较好的抑菌活性, 并对席夫碱结构与活性的关系进行了探讨.

关键词: 席夫碱, 三唑硫酮, 合成, 生物活性

Thiocarbazide was reacted with acetic acid to prepare 4,5-dihydro-3-methyl-4-amino-1,2, 4-triazole-5-thione. Then eight Schiff bases were synthesized using this 1,2,4-triazole-5-thione and substituted aromatic aldehydes as starting materials, with acetic acid as a catalyst and solvent. The structures of all the compounds have been confirmed by 1H NMR, IR and elemental analysis. Their biological activities to several vegetable pathogens have been tested and the results showed that they exhibited good fungicidal activities.

Key words: Schiff base, triazolethione, synthesis, biological activity