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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (14): 1700-1704. 上一篇    下一篇

研究简报

3β-羟基-24-降胆-5-烯-23-酸的合成

任小娟 韩满意 李 瀛 谢志翔

  

  1. (兰州大学化学化工学院功能有机分子国家重点实验室 兰州 730000)

  • 投稿日期:2008-12-15 修回日期:2009-02-25 发布日期:2009-07-28
  • 通讯作者: 谢志翔

Synthesis of 3β-Hydroxy-24-norchol-5-en-23-oic Acid

Ren, Xiaojuan Han, Manyi Li, Ying Xie, Zhixiang   

  1. (State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering,
    Lanzhou University, Lanzhou 730000)
  • Received:2008-12-15 Revised:2009-02-25 Published:2009-07-28
  • Contact: Xie, Zhixiang

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以妊娠双烯醇酮醋酸酯为起始原料, 经过6步反应以28.2%的总收率, 合成了具有抗炎活性的海洋天然产物3β-羟基-24-降胆-5-烯-23-酸. 关键反应为钯催化的烯丙基烷基化.

关键词: 海洋天然产物, 胆甾烷, 抗炎, 合成, 烯丙基烷基化

The synthesis of 3β-hydroxy-24-norchol-5-en-23-oic acid, an anti-inflammatory marine natural product, was achieved from commercial available 16-dehydropregnenolone acetate in six steps with a 28.2% overall yield. The key step was palladium catalyzed allylation.

Key words: FONT-FAMILY: 'Times New Roman', mso-bidi-font-size: 12.0pt, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA">marine natural product, cholestane, anti-inflammatory