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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (17): 2025-2030. 上一篇    下一篇

研究论文

水相合成CdX (X＝Te, Te/CdS, Te/ZnS)红色量子点及毒性效应

王显祥*,a,c 黄 娟b 靳茹文b 杨中科b 单 志a 杨婉身a

  

  1. (a四川农业大学生命科学与理学院 雅安 625014)
    (b四川农业大学动物医学院 雅安 625014)
    (c四川大学化学学院 成都 610041)

  • 投稿日期:2009-04-07 修回日期:2009-06-10 发布日期:2009-09-14
  • 通讯作者: 王显祥

Aqueous Phase Synthesis of Red CdX (X＝Te, Te/CdS, Te/ZnS) Quantum Dots and Their Toxic Effects

Wang, Xianxiang*,a,c Huang, Juanb Jin, Ruwenb Yang, Zhongkeb
Shan, Zhia Yang, Wanshena

  

  1. (a College of Life and Science, Sichuan Agricultural University, Ya’an 625014)
    (b College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014)
    (c College of Chemistry, Sichuan University, Chengdu 610041)

  • Received:2009-04-07 Revised:2009-06-10 Published:2009-09-14
  • Contact: Wang, Xianxiang

PDF

2438

被引次数

5

分别以巯基乙酸(Mercaptoacetic Acid, MA)、还原型谷胱甘肽(Glutathione, GSH)为稳定剂在水相中直接合成了巯基乙酸CdTe (CdTe-MA)、红色巯基乙酸CdTe/CdS (CdTe/CdS-MA)、巯基乙酸CdTe/ZnS (CdTe/ZnS-MA)及谷胱甘肽CdTe (CdTe-GSH)量子点. 其中, CdTe-GSH量子点的量子产率可达47.3%. 体外溶血实验证实CdTe/ZnS-MA和CdTe-GSH量子点的溶血率较CdTe-MA和CdTe/CdS-MA低, 浓度为0.05 mmol/L的量子点溶血率＜5%, 达到了生物医用材料的要求. 活体实验证实: 通过尾静脉方式把量子点注入小鼠体内后, 荧光显微镜观察发现高剂量的量子点(0.4 mmol/10 g)在体内主要在心、肝、脾、肾组织中分布较多, 且引起不同程度的组织病变.

关键词: 红色量子点, 溶血, 毒性, 谷胱甘肽

Mercaptoacetic acid (MA) capped CdTe, CdTe/CdS, CdTe/ZnS quantum dots (QD) and glutathione (GSH)-capped CdTe QDs were directly synthesized in aqueous media. The fabricated CdTe-GSH QDs have an ultra small hydrodynamic diameter (3～4 nm) and possess high quantum yields (47.3%). In vitro hemolysis testing showed that the hemolysis rates (HR) of CdTe/ZnS-MA and CdTe-GSH were less than 5% (concentration being 0.05 mmol/L), which were lower than CdTe-MA and CdTe/CdS-MA QDs, meeting the requirements for biomedical materials. The toxicity of QD in vivo was tested by injected QD in mice through tail vein. Fluorescence microscopy showed that a high dosage (0.4 mmol/10 g) of CdTe-GSH and CdTe/ZnS-MA QD was distributed mainly in the heart, liver, spleen and kidney tissues and caused varying degrees of tissue lesions.

Key words: red quantum dot, hemolysis, toxicity, glutathione

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