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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (2): 139-144. 上一篇    下一篇

研究论文

2-苯并咪唑吡啶镍配合物的合成﹑晶体结构及与DNA相互作用的共振散射光谱研究

朱 莉*,a,b 于贤勇b 龙云飞b 林原斌*,a

  

  1. (a湘潭大学化学学院 湘潭 411105)
    (b湖南科技大学化学化工学院 分子构效关系湖南省普通高等学校重点实验室 湘潭 411201)

  • 投稿日期:2008-09-19 修回日期:2008-10-20 发布日期:2009-01-28
  • 通讯作者: 朱莉

Synthesis, Crystal Structure and Resonance Light Scattering Spectral Study on the Interaction of DNA with 2(Pyridi-2-yl)benzimidazole Nickel(II) Complex

Zhu, Li* ,a,b Yu, Xianyongb Long, Yunfei b Lin, Yuanbin *,a   

  1. (a Chemistry Institute, Xiangtan University, Xiangtan 411105)
    (b Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering,
    Hunan University of Science and Technology, Xiangtan 411201, China)
  • Received:2008-09-19 Revised:2008-10-20 Published:2009-01-28
  • Contact: Zhu, Li

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被引次数

54 | 7

合成了2-苯并咪唑吡啶镍配合物[Ni(C12H9N3)3](ClO4)2•H2O, 通过IR, UV-Vis和元素分析对其进行了表征, 并通过X射线单晶衍射确定了其晶体结构. 单晶结构分析表明, 该晶体属于三斜晶系, 空间群为 , a＝1.20076(5) nm, b＝1.22545(5) nm, c＝1.49077(5) nm, α＝88.2430(10)°, β＝71.7970(10)°, γ＝72.544(2)°, Z＝2, 最终偏离因子R1＝0.0608, wR2＝0.1859. 配合物的金属中心与6个配位氮原子形成八面体的几何构型. 用共振瑞利散射(RRS)研究了配合物与DNA的作用, 配合物与DNA相互作用形成复合产物并出现了相应的新的RRS光谱, 且随着配合物浓度的增大引起共振瑞利散射增强, 在低离子强度的环境下与DNA的作用比较明显. 这些实验结果表明了配合物与DNA之间存在较强的相互作用.

关键词: 2-苯并咪唑吡啶, 镍(II)配合物, 合成, 晶体结构, DNA, 共振瑞利散射

A nickel(II) complex with 2(pyridi-2-yl)benzimidazole [Ni(C12H9N3)3](ClO4)2•H2O has been synthesized and characterized by elemental analysis, IR, UV and single crystal X-ray diffraction methods. The crystal of nickel(II) complex belongs to triclinic system with space group, , a＝1.20076(5) nm, b＝1.22545(5) nm, c＝1.49077(5) nm, α＝88.2430(10)°, β＝71.7970(10)°, γ＝72.544(2)°, Z＝2, the final R1＝0.0608, and wR2＝0.1859. The nickel(II) atom of the metal center in complex has an octahedral coordination geometry and is six-coordinated by six nitrogen atoms from three organic ligands. A resonance scattering spectral method has been used for the study on the interaction of DNA with nickel(II) complex. The results show that the corresponding resonance Rayleigh scattering (RRS) spectrum appeared and RRS was enhanced with the growth of the concentration of Ni(II) complex. All of the results indicate that there is strong interaction of the Ni(II) complex with DNA.

Key words: 2(pyridi-2-yl)benzimidazole, nickel(II) complex, synthesis, DNA, resonance Rayleigh scattering