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化学学报 ›› 2009, Vol. 67 ›› Issue (21): 2523-2526. 上一篇 下一篇
研究简报
蔡良珍,刘斌,董于虎,杜广延,陶晓春
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通讯作者:
Cai, Liangzhen Liu, Bin Dong, Yuhu Du, Guangyan Tao, Xiaochun*
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以亚铁氰化钾为氰基化试剂, 加入N,N-二甲基乙二胺、异丙基咪唑与催化量的碘化亚铜, 从一系列含氮杂环溴化物制备相应的氰基化合物, 操作简便, 分离收率高, 并且环保.
关键词: 亚铁氰化钾, 氰基化, 异丙基咪唑, N,N-二甲基乙二胺, 含氮杂环氰基化合物
An efficient and user-friendly synthesis for a series of N-heteroaryl nitriles is described. This process is based on the CuI catalyzed cyanation of N-heteroaryl bromides with K4[Fe(CN)6] in the presence of N-isopropylimidazole and N,N-dimethylethylenediamine. The results show that the reaction has good to high yields.
Key words: potassium hexacyanoferrate(II), cyanation, N-isopropylimidazole, N,N-dimethylethylene- diamine, N-heteroaryl nitrile
蔡良珍, 刘斌, 董于虎, 杜广延, 陶晓春. 铜(Ⅰ)催化亚铁氰化钾对含氮杂环溴化物的氰基化反应[J]. 化学学报, 2009, 67(21): 2523-2526.
CA Liang-Zhen, LIU Bin, DONG Xu-Hu, DU An-Yan, DAO Xiao-Chun. Copper(I) Iodide Catalyzed Cyanation of N-Heteroaryl Bromides Using Potassium Hexacyanoferrate(II)[J]. Acta Chimica Sinica, 2009, 67(21): 2523-2526.
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