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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (21): 2523-2526. 上一篇    下一篇

研究简报

铜(Ⅰ)催化亚铁氰化钾对含氮杂环溴化物的氰基化反应

蔡良珍,刘斌,董于虎,杜广延,陶晓春   

  1. (华东理工大学化学与分子工程学院 上海 200237)
  • 投稿日期:2009-05-08 修回日期:2009-07-01 发布日期:2010-01-05
  • 通讯作者: 陶晓春 E-mail:xctao@ecust.edu.cn

Copper(I) Iodide Catalyzed Cyanation of N-Heteroaryl Bromides Using Potassium Hexacyanoferrate(II)

Cai, Liangzhen      Liu, Bin       Dong, Yuhu       Du, Guangyan      Tao, Xiaochun*   

  1. (School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237)
  • Received:2009-05-08 Revised:2009-07-01 Published:2010-01-05

PDF

3104

被引次数

9

以亚铁氰化钾为氰基化试剂, 加入N,N-二甲基乙二胺、异丙基咪唑与催化量的碘化亚铜, 从一系列含氮杂环溴化物制备相应的氰基化合物, 操作简便, 分离收率高, 并且环保.

关键词: 亚铁氰化钾, 氰基化, 异丙基咪唑, N,N-二甲基乙二胺, 含氮杂环氰基化合物

An efficient and user-friendly synthesis for a series of N-heteroaryl nitriles is described. This process is based on the CuI catalyzed cyanation of N-heteroaryl bromides with K4[Fe(CN)6] in the presence of N-isopropylimidazole and N,N-dimethylethylenediamine. The results show that the reaction has good to high yields.

Key words: potassium hexacyanoferrate(II), cyanation, N-isopropylimidazole, N,N-dimethylethylene- diamine, N-heteroaryl nitrile