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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (02): 157-161. 上一篇    下一篇

研究论文

妥拉苏林分子印迹膜传感器的制备及识别特性研究

张进1,2，徐岚*,1，吕瑞红1，王亚琼1   

  1. (1西南大学化学化工学院 发光与实时分析教育部重点实验室 重庆 400715)
    (2贵州师范学院 化学与生命科学学院 贵阳 550018)
  • 投稿日期:2009-07-04 修回日期:2009-09-14 发布日期:2010-03-17
  • 通讯作者: 王亚琼 E-mail:xulan@swu.edu.cn

Preparation and Characterization of Tolazoline Sensor Based on Molecularly Imprinted Polymer

Zhang Jin1,2 Xu Lan*,1 Lü Ruihong1 Wang Yaqiong1   

  1. (1 Key Laboratory on Luminescence and Real-Time Analysis of Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715)
    (2 School of Chemistry and Life Science, Guizhou Normal College, Guiyang 550018)
  • Received:2009-07-04 Revised:2009-09-14 Published:2010-03-17

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1694

被引次数

36 | 3

用电聚合的方法在金电极上制备了以妥拉苏林为模板分子的自组装邻氨基硫酚分子印迹膜传感器. 通过差分脉冲伏安法研究传感器对妥拉苏林的响应特性, 结果表明在优化的实验条件下, 此传感器的峰电流响应值与妥拉苏林浓度在0.4～5 μg•mL－1 (r＝0.9986)和5～120 μg•mL－1 (r＝0.9953)范围内保持良好的线性关系, 检测限为0.18 μg•mL－1; 相对标准偏差约为2.47%, 响应时间约为3 min. 传感器具备较好的选择性和稳定性, 初步用于人体尿液中妥拉苏林的分析, 获得了较满意的结果.

关键词: 电化学传感器, 分子印迹技术, 电聚合物膜, 妥拉苏林

A novel electrochemical sensor for the detection of tolazoline based on molecularly imprinted polymer of electropolymerized o-aminothiophenol onto a gold electrode was constructed. Its response to tolazoline was evaluated by differential pulse voltammmograms (DPV). Under the optimized conditions, the response current of the proposed sensor decreased linearly in two concentration ranges of tolazoline from 0.4 to 5 μg•mL－1 (r＝0.9986) and from 5 to 120 μg•mL－1 (r＝0.9953) with a detection limit of 0.18 μg•mL－1. The RSD (relative standard deviation) was about 2.47% and the response time was closed to 3 min. Moreover, the studied imprinted sensor exhibited high selectivity and long-term stability, and was successfully applied to the determination of tolazoline in human urine samples.

Key words: electrochemical sensor, molecular imprinting technique, electropolymerization film, tolazoline