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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (12): 1247-1251. 上一篇    

研究简报

新型胆固醇侧部衍生物的合成研究

王斌，张军华   

  1. 四川大学高分子材料工程国家重点实验室 成都 610065
  • 投稿日期:2009-10-28 修回日期:2009-12-25 发布日期:2010-02-25
  • 通讯作者: 张军华 E-mail:zhangjh@scu.edu.cn.
  • 基金资助:

    20804026

Study of Synthesis of New Type of Side Cholesteric Derivatives Wang Bin Zhang Junhua

WANG Bin, ZHANG Jun-Hua   

  1. State Key Laboratory of Polymer Materials Engineering of China, Sichuan University, Chengdu 610065
  • Received:2009-10-28 Revised:2009-12-25 Published:2010-02-25

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1272

被引次数

3

由于胆固醇和氢化胆固醇均是较好的液晶基元, 引起了广泛的关注和研究. 在胆固醇分子中, C(3)上有一个羟基, C(5)＝C(6)之间含有一个双键, 双键的存在使得胆固醇分子具有较好的刚性, 因此大量的研究工作都集中在利用C(3)上的羟基制备胆固醇衍生物. 但是C(5)＝C(6)之间的双键也是可以利用的官能团, 可以在胆固醇分子的双键部位引入适当的官能团, 而得到一些新的衍生物, 因此, 对胆固醇C(5)＝C(6)位双键的化学修饰就成了本研究的重点. 首次探讨了将6-溴己酸或丙烯酸通过双键环氧化, 然后开环的方法连到胆固醇侧部双键位置, 为合成新型的含胆固醇衍生物的聚合物研究奠定了基础.

关键词: 胆固醇, 双键, 化学修饰, 胆固醇衍生物

Cholesterol and dihydrocholesterol had brought comprehensive attentions and investigations, due to good mesogen units. There is a hydroxy on C(3), and double bonds on C(5)＝C(6) in cholesterol structure, which make the cholesterol molecule have more rigid, so much work all focused on liquid crystalline through synthesizing cholesterol derivatives from the hydroxy on C(3). However the double bond of C(5)＝C(6) is also utilizable functional group, and it can get new series of cholesteric derivatives through introducing proper organic group. So the chemical modification of the double bond on cholesterol is the purpose, it was firstly discussed of the method that 6-bromohexane or acrylic acid link the cholesterol lateral, which was established for the investigation of cholesteric derivatives.

Key words: cholesterol, double bond, chemical modification, cholesteric derivatives