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化学学报
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化学学报 ›› 1991, Vol. 49 ›› Issue (1): 81-87. 上一篇    下一篇

研究论文

具有生物活性的有机硅化合物的研究X. 3-(三甲硅基)丙基硫代 (N-取代)乙酰胺 的合成和质谱研究

谢庆兰;贺水济;单志兴;张法义;林Chui;黄承义   

  1. 南开大学元素有机化学研究所.天津(300071);南开大学测试计算中心.天津 (300071)
  • 发布日期:1991-01-15

Studies on organosilicon compounds with biological activity X. synthesis of 3-(trimethylsilyl) propylthio (N-substituted) acetamide and study on mass spectra

Xie Qinglan;He Shuiji;Shan Zhixing;Zhang Fayi;LIN Chu;Huang Chengyi   

  1. Nankai Univ, Elementoorgan Chem Lab.Tianjin(300071);Nankai Univ., Center of Testing and Computer.Tianjin(300071)
  • Published:1991-01-15

PDF

547

被引次数

37

本文合成了15个3-(三甲硅基)丙基硫代(N-取代)乙酰胺类化合物。通过对这些化合物的红外光谱和核磁共振(^1H,^1^3C)谱的研究,确证了它们的表征结构。质谱数据表明,这类化事物的裂解机理主要取决于硅烷、酰胺和硫醚的断裂方式。这类化合物的毒性较大,不利于用作抗癌试验。

关键词: 质谱研究, 合成, 乙酰胺, 三甲硅基, 生物活性, 硫代乙酰胺, 酰胺类化合物, 核磁共振, 红外分光光度法, 裂解机理

Fifteen 3-(trimethylsilyl)propylthio (N-substituted) acetamides were synthesized. Their structure was studied by IR and NMR (^1H, ^1^3C). The MS of these products were determined. It has been found that fragmentation mechanism is dependent mainly on the fragment of Si-C, amide bonds and thio-ether bonds. These compounds are highly toxic.

Key words: MASS SPECTROGRAPHY, SYNTHESIS, ACETAMIDE, BIOLOGICAL ACTIVITY, THIOACETAMIDE, NUCLEAR MAGNETIC RESONANCE, INFRARED SPECTROPHOTOMETRY

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