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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (10): 1893-1898. 上一篇    

研究论文

1-(2-咪唑啉酮基)-1H-1,2,4-三唑衍生物的合成与杀菌活性

丁明武;宿亚丽;刘小鹏;刘钊杰   

  1. 华中师范大学有机合成研究所,武汉(430079)
  • 发布日期:2002-10-15

Synthesis and Fungicidal Activities of 1-(2-Imidazolonyl)-1,2,4- triazoles

Ding Mingwu;Shu Yali;Liu Xiaopeng;Liu Zhaojie   

  1. Institute of Organic Synthesis, Central China Normal University, Wuhan(430079)
  • Published:2002-10-15

PDF

511

被引次数

75

研究了应用烯基膦亚胺（1）与芳基异氰酸酯、1H-1,2,4-三唑的串联欢氮杂 Wittig反应，合成1-(2-咪唑啉酮基)-1H-1,2,4-三唑衍生物（3）的方法，探讨了 成环反应的条件以及所合成的新型杂环化合物的杀菌活性。结果表明部分化合物表 现出良好的抑菌活性，其中以3d活性最好，在50 mg/L浓度时，对稻瘟菌、水稻纹 枯菌、棉花枯萎菌、苹果轮纹菌及小麦赤霉菌的抑制率均达100%，对芦笋褐斑菌的 抑制率亦达81%。

关键词: 三唑, 咪唑酮 P, 异氰酸酯, 杀菌剂, 亚胺

1-(2-Imidazolonyl)-1,2,4-triazoles(3) were synthesized via tandem aza-Wittig reaction of vinyliminophosphorane (1) with aromatic isocynate and 1H-1,2,4-triazole. The conditions for cyclization were examined. Some of the compounds exhibited good fungicidal activities. The best one was compound 3d showing 100% inhibition of Pyricularia oryzae, Pellicularia sasakii, Fusarium oxysporum, Physalospora piricola and Gibberella zeae as well as 81% inhibition of Cercospora asparagagas at 50 mg/L.

Key words: TRIAZOLE, MIDAZOLONE P, SOCYANIC ESTERS, BACTERICIDAL AGENTS, IMINE

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