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化学学报
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化学学报 ›› 1993, Vol. 51 ›› Issue (10): 1005-1009. 上一篇    下一篇

研究论文

亲水性二苯甲胺树脂制备及用于肽合成研究

程晓辉;阎虎生;倪爱国;何炳林   

  1. 南开大学高分子化学研究所
  • 发布日期:1993-10-15

Preparation of hydrophilic benzhydrylamine resin and its application in solid phase peptide synthesis

CHENG XIAOHUI;YAN HUSHENG;NI AIGUO;HE BINGLIN   

  • Published:1993-10-15

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通过反相悬浮共聚合成了含酯基的聚丙烯酰胺树脂, 再经乙二胺取代和两步缩合反应引入二苯甲胺功能基团。讨论了反应条件对各步反应的影响。测定了该载体与几种保护氨基酸的缩合率并合成了模型肽。缩合率和模型肽的纯度都令人满意。

关键词: 合成, 聚丙烯酰胺, 多肽, 亲水性, 二苯甲胺基树脂

Ester group-contg. polyacrylamide resin was prepared with reverse phase suspension copolymn.; the benzhydrylamine groups were introduced to the polymer by ethylenediamine substitution and two-step condensation. The effect of reaction conditions was studied. With the use of the prepared support, a model peptide was synthesized. Condensation yields in the peptide synthesis were measured. The yields and purity of the peptide were satisfactory.

Key words: SYNTHESIS, POLYACRYLAMIDE, POLYPEPTIDE, HYDROPHILICITY

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