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化学学报
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化学学报 ›› 2003, Vol. 61 ›› Issue (9): 1382-1387. 上一篇    下一篇

研究论文

钇离子及其阳离子卟啉配合物与金黄色葡萄球菌的相互作用

侯安新;刘义;黄伟国;薛智;屈松生   

  1. 武汉大学化学与分子科学学院;香港浸会大学化学系
  • 发布日期:2003-09-15

Interaction of Y~(3+) and Its Cationic Monoporphyrinate Complex with Staphylococcus aureus

Hou Anxin;Liu Yi;Wong Wai-kwok;Xue Zhi;Qu Songsheng   

  1. Department of Chemistry, Wuhan University;Department of Chemistry, Hong Kong Baptist University
  • Published:2003-09-15

PDF

640

被引次数

112 | 15

用LKB-2277生物活性检测系统考察了Y~(3+)，TMP及其阳离子型钇卟啉配合物 {[Y(TMP)(H_2O)_3]Cl, TMP = 5, 10, 15, 20-四（4-甲氧基苯基）卟啉}对金黄色 葡萄球菌全程代谢作用的影响，测定了Y~(3+)，TMP和[Y(TMP)(H_2O)_3]Cl对金黄 色葡萄球菌作用的产热曲线，根据产热曲线求算了金黄色葡萄球菌在Y~(3+)，TMP ，[Y(TMP)(H_2O)_3]Cl作用下生长代谢的速率常数k_1，k_2，抑制率I_1，I_2，和 半抑制浓度IC_(50)~1，IC_(50)~2等热动力学参数。实验结果表明：Y~(3+)，[Y (TMP)(H_2O)_3]Cl对金黄色葡萄球菌的生长代谢有双向调节作用，在低浓度下表现 为刺激作用，高浓度为抑制作用，而TMP对金黄色葡萄球菌的生长代谢主要为抑制 作用，在低浓度下表现为刺激作用，高浓度为抑制作用，而TMP对金黄色葡萄球菌 的生长代谢主要为抑制作用，对金黄色葡萄球菌的抑制作用[Y(TMP)(H_2O)_3]Cl > TMP > Y~(3+)。

关键词: 钇化合物, 卟啉, 金黄色葡萄球菌, 热动力学, 抑制

The biothermochemical characteristics of the actions of Y , TMP and their cationic monoporphyrinate complex |[Y(TMP)(H2O)3]Cl, TMP= 5,10, 15,20-tetrakis(4'-methoxyphenyl)porphyrin| on growth metabolism of Staphylococcus aureus were studied by means of a LKB-2277 Bioactivity Monitor at 37.00 ℃. The growth rate constants k_1, k_2 inhibiting ratio I( %), the total heat effect (Q_(total)) and half inhibition of concentration IC50 (mg· L~(-1)), respectively were obtained. Experimental results show that Y~(3+) and [Y(TMP) (H_2O)_3]C1 have the duplex biological effection: they stimulate the growth of the Staphylococcus aureus at lower concentration but inhibit the growth at high concentration. Inhibitory effection of Y~(3+) , TMP and [Y(TMP) (H_2O)_3]Cl is [Y(TMP)(H_2O)_3]C1> TMP>Y~(3+).

Key words: YTTRIUM COMPOUNDS, PORPHYRIN, STAPHYLOCOCCUS ARUEUS, THERMODYNAMICS, DEPRESSING

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