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化学学报
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化学学报 ›› 1993, Vol. 51 ›› Issue (7): 708-712. 上一篇    下一篇

研究论文

绞股蓝皂苷酸水解次生苷元的分离与鉴定

马建标;赵存祥;范云鸽;何炳林   

  1. 南开大学高分子化学研究所
  • 发布日期:1993-07-15

The formation, separation and structural elucidation of the secondary sapogenins of gypenosides

MA JIANBIAO;ZHAO CUNXIANG;FAN YUNGE;HE BINGLIN   

  • Published:1993-07-15

PDF

346

被引次数

19

绞股蓝皂苷用5%硫酸水解,生成的次生皂苷元除已报道的人参二醇和2α-羟基人参二醇之外,尚分离到(20R.25S)-12β,25-环氧20,26-环达玛烷-2α,3β-二醇一新化合物.其结构经波谱分析和X射线衍射鉴定,确证20-C和25-C手性中心的绝对构型分别为R和S型.

关键词: 反应机理, 皂角苷, Ｘ射线衍射分析, 水解, 达马烷, 三萜

Gypenosides, a series of dammarane-type saponins from Gynostemma pentaphyllum (Thunb.) Makino, were hydrolyzed with 5% sulfuric acid to afford a new secondary sapogenin (20R,25S)-12b,25-epoxy-20,26-cyclodammarane-2a,3b-diol in addition to the known panaxadiol, 2a-hydroxypanaxadiol, and (20R,25S)-12b,25-epoxy-20,26-cyclodammaran-3b-ol. The mol. structure of the new secondary sapogenin was elucidated by means of spectroscopic methods and x-ray crystallog. anal.

Key words: REACTION MECHANISM, SAPONINS, X-RAY DIFFRACTION ANALYSIS, HYDROLYSIS, DAMMARAN, TRITERPENE

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