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化学学报
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化学学报 ›› 1991, Vol. 49 ›› Issue (2): 121-127. 上一篇    下一篇

研究论文

合成双分子膜的研究I. 单链1, 5取代萘刚性生色基的双亲化合物的合成及其在稀溶液中的自组织规律

李国文;田永驰;梁映秋   

  1. 吉林大学理论化学研究所
  • 发布日期:1991-02-15

Studies on synthetic bilayer membranes I. Synthesis of single-chain amphiphiles with the naphthalene moiety and self-organization of the amphiphiles in dilute aqueous solution

LI GUOWEN;TIAN YONGCHI;LIANG YINGQIU   

  • Published:1991-02-15

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本文首次报道了系列单链、1, 5取代萘刚性生色基团的两亲化合物C~nNaph(1,5)C~6N^+(n=16, 12, 10, 8, 6和4)的合成。用电镜、1^H NMR和DSC分别观察了该系列化合物在稀溶液中的聚集形态、聚集体内分子运动和物相变化。结果表明: 当n≥8时, 该系列双亲化合物在稀溶液中自组织成双层结构的囊泡, 泡壁为双分子膜。n=6时, 囊泡形状不完整。n=4时, 聚集体无确定形态。

关键词: 水溶液, 电子显微镜分析, 三甲基烷基铵, 萘 P, 溴代烃, 质子磁共振谱法, 示差扫描量热法, 双分子膜, 聚集体

A series of single-chain amphiphiles with the naphthalene moiety and the (CH) spacer chain, Cn Naphth(1,5)C6N+(n = 16, 12, 10, 8, 6, 4), were synthesized. The aggregate morphol. of the amphiphiles in dilute aqueous solution was examined by electron microscopy, and found to form aggregate global-shaped vesicles with diameter of 50 -200 nm when n = 8. It has not a fixed shape when n = 4. The mol. movement in aggregate of the anphiphiles was observed by 1H NMR. The gel-to-liq. crystal phase transition of the bilayer was shown by differential scanning calorimetry (DSC). These results indicate that the amphiphiles are of practical bilayer-forming, capable of organizing biomembrane mimetic agent and suggest that the vesicle structures are composed of the bilayer structure similar to that of biomembranes.

Key words: AQUEOUS SOLUTION, ELECTRON-MICROSCOPIC ANALYSIS, TRIMETHYLALKYLAMMONIUM, NAPHTHALENE P, BROMOHYDROCARBON, PROTON MAGNETIC RESONANCE SPECTROMETRY, DIFFERENTIAL SCANNING CALORIMETRY, BILAYER MEMBRANE, AGGREGALES

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