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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (8): 779-783. 上一篇    下一篇

研究论文

硅凝胶体系中不同结构羧酸钾对草酸钙结晶的影响

柳一鸣1,2，袁欢欣2，陈村元2，姚秀琼2，谭燕华2，欧阳健明*,2   

  1. (1湖南理工大学化学化工系 湖南岳阳 414000)
    (2暨南大学生物矿化与结石病防治研究所 广州 510632)
  • 投稿日期:2005-11-24 修回日期:2006-02-27 发布日期:2006-04-25
  • 通讯作者: 欧阳健明

Effect of Different Kinds of Potassium Carboxylates on Growth of Calcium Oxalate Crystals in Silica Gel System

LIU Yi-Ming1,2, YUAN Huan-Xin2, CHEN Cun-Yuan2, YAO Xiu-Qiong2，TAN Yan-Hua2, OUYANG Jian-Ming*,2   

  1. (1 Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000)
    (2 Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632)
  • Received:2005-11-24 Revised:2006-02-27 Published:2006-04-25
  • Contact: OUYANG Jian-Ming

PDF

1013

被引次数

13

采用扫描电子显微镜(SEM)和X射线衍射(XRD)方法研究了硅凝胶体系中不同种类羧酸钾对草酸钙(CaC2O4)晶体生长的调控作用. 加入一元醋酸钾(KOAc)只生成一水草酸钙(COM)晶体; 三元柠檬酸钾(K3Cit)和四元乙二胺四乙酸二钾(K2EDTA)可诱导二水草酸钙(COD)形成, 且随着其浓度增加, 对COD的诱导能力增加, 而二元酒石酸钾(K2Tart)同时诱导了COM, COD和三水草酸钙(COT)生成. 随着结晶温度降低, 多元酸钾可以进一步减小COM晶体的比表面积, 增加COD的百分含量, 但K2Tart诱导COT的能力减弱. 由于诱导COD和COT晶体形成、减小COM的比表面积均有利于防止草酸钙尿石的形成, 因此, 多元羧酸钾可用于草酸钙结石的预防和治疗.

关键词: 草酸钙, 羧酸钾, 尿结石

The effect of different kinds of potassium carboxylates on the crystallization of calcium oxalate (CaC2O4) was investigated in silica gel system by means of scanning electron microscopy and X-ray diffraction. The investigated potassium carboxylates included: monocarboxylate potassium acetate (KOAc), dicarboxylate potassium tartrate (K2Tart), tricarboxylate potassium citrate (K3Cit), and tetracarboxylate dipotassium of ethylenediaminetetraacetic acid (K2EDTA). KOAc can only induce calcium oxalate monohydrate (COM), while K3Cit and K2EDTA induce COM and calcium oxalate dihydrate (COD). The ability of multicarboxylates to induce COD formation was increased with increasing their concentrations. Calcium oxalate trihydrate (COT) was induced by K2Tart. As the crystallization temperature was decreased, the percentage of COD crystals increased, the surface area of COM crystals decreased, but the percentage of COT crystals induced by K2Tart decreased. Since both increasing the content of COD or COT and decreasing the surface area of COM crystals favor the inhibition of CaC2O4 stones, potassium multicarboxylates can be used to prevent and cure this disease.

Key words: calcium oxalate, potassium carboxylate, urinary stone