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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (9): 879-883. 上一篇    下一篇

研究论文

双(2-取代-3-羟基-4-吡喃酮)合铜(II)配合物的合成和降血糖作用

谌喜珠1，牛艳芬2，刘伟平*,1，李玲2，王玉天1
李艳蓉2，高文桂1，余尧1   

  1. (1昆明贵金属研究所 昆明 650221)
    (2云南省天然药物药理重点实验室 昆明 650031)
  • 投稿日期:2005-08-05 修回日期:2006-01-13 发布日期:2006-05-15
  • 通讯作者: 刘伟平

Synthesis and Anti-hyperglycemic Effect of Copper(II) Bis(2-substituted 3-hydroxy-4-pyronate)

CHEN Xi-Zhu1, NIU Yan-Fen2, LIU Wei-Ping*,1, LI Ling2, WANG Yu-Tian1, LI Yan-Rong2, GAO Wen-Gui1, YU Yao1   

  1. (1 Kunming Institute of Precious Metals, Kunming 650221)
    (2 Yunnan Pharmacological Laboratories of Natural Products, Kunming 650031)
  • Received:2005-08-05 Revised:2006-01-13 Published:2006-05-15
  • Contact: LIU Wei-Ping

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合成了双(2-取代-3-羟基-4-吡喃酮)合铜(II)配合物, 采用元素分析、质谱、红外光谱、电子光谱、电子自旋共振谱表征了它们为平面正方型配合物, 中心离子和配体的物质的量比为1∶2. 在STZ-糖尿病小鼠模型上, 其中双(2-乙基-3-羟基-4-吡喃酮)合铜(II)在10 mg/kg的剂量下灌胃给药, 能增加血清胰岛素的合成和分泌、降低糖尿病小鼠的血糖水平, 显示出良好的抗糖尿病的作用. 该配合物毒性低, 对正常小鼠灌胃给药的半数致死量LD50是855.9 mg/kg.

关键词: 铜(II), 3-羟基-4-吡喃酮, 合成, 降血糖作用

Copper(II) bis(2-substituted 3-hydroxy-4-pyronate), where the substituent is CH3/C2H5/CH2OH, was synthesized by the reaction between CuCl2 and sodium 2-substituted 3-hydroxy-4-pyronate in aqueous solution, followed by recrystallizaton in water. By using elemental analysis, IR, UV, MS and EPR spectra, their chemical structures were determined to be planar square complexes with 1∶2 molar ratio of Cu to the pyronate in a molecule. The complexes were submitted to the test of preliminary toxicity and anti-hyperglycemic effect on STZ-diabetic mice. The results show that one of the complexes, copper(II) bis(2-ethyl-3-hydroxy-4-pyronate), increased the synthesis and release of the serum insulin, and lowered the blood glucose level in mice at the dose of 10 mg/kg, exhibiting good anti-hyperglycemic activity. The complex was also safe with LD50 of 855.9 mg/kg in healthy mice.

Key words: copper(II), 3-hydroxy-4-pyrone, synthesis, anti-hyperglycemic effect