化学学报 ›› 1987, Vol. 45 ›› Issue (4): 328-333. 上一篇    下一篇

研究论文

兴国乌头碱及其氢溴酸盐的结构

郑培菊;汪明;王博义;田如美;蒋山好;周炳南   

  1. 复旦大学分析测试中心;中国科学院上海药物研究所
  • 发布日期:1987-04-15

The structures of finetianine and its hydrobromide

ZHENG PEIJU;WANG MING;WANG BOYI;TIAN RUMEI;JIANG SHANHAO;ZHOU BINGNAN   

  • Published:1987-04-15

研究了兴国乌头碱(C21H29NO3)及其氢溴酸盐的晶体.结构均采用全矩阵最小二乘法精修.运用反常散射法测定氢溴酸盐绝对构型,从而确定了兴国乌头碱的绝对构型.在两个结构中,A环与E环都成稳定的椅式构象,B环与C环则呈船型,分子间均存在较强的氢键,形成稳定的晶体.结构中有十个不对称碳原子.

关键词: 晶体结构测定, 分子结构, X射线衍射分析, 二萜烯生物碱, 乌头, 氢键, 溴酸盐, 绝对构型

The structure of finetianine (I) and its hydrobromide were determine by single crystal x-ray diffraction anal. Their absolute configuration and conformation were also established.

Key words: CRYSTAL STRUCTURE DETERMINATION, MOLECULAR STRUCTURE, X-RAY DIFFRACTION ANALYSIS, DITERPENE ALKALOID, ACONITUM CARMACHAELI, HYDROGEN BONDS, BROMATE, ABSOLUTE CONFIGURATION

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