化学学报 ›› 1999, Vol. 57 ›› Issue (6): 622-626. 上一篇    下一篇

研究论文

α-羰基一硫代半缩醛与脂肪族脲反应合成2, 4-咪唑啉二酮衍生物

邱丽华;彭运开;邹建平;陆忠娥   

  1. 苏州医学院化学教研室;苏州大学化学化工学院
  • 发布日期:1999-06-15

Preparation of 2, 4-imidazolidinediones (hydantoins) from α-keto hemithioacetal and alkyl ureas

Qiu Lihua;Peng Yunkai;Zou Jianping;Lu Zhonge   

  • Published:1999-06-15

利用α-羰基一硫代半缩醛与脂肪基取代脲反应合成了六个新的咪唑啉二酮类衍生物。并用IR,NMR,MS和元素分析进行测定,最后用X四圆衍射仪确定了它们的结构。

关键词: 半缩醛, 脲, 咪唑酮P, 红外分光光度法, 核磁共振谱法, 质谱法, 元素分析, X四圆衍射仪

1-alkyl-5-phenyl-2, 4-imidazolidinediones (4a-4f) have been synthesized by the reaction of α-keto hemithioacetal (1) and alkylureas (3a-3f) in the slightly acidic medium. The structure of compounds (4a-4f) were confirmed by the MS, NMR, IR spectra, elementary analysis and X-ray diffraction study. This reaction provides a new convenient method for synthesis of 1, 5-disubstituted- 2, 4-imidazolidinediones.

Key words: HEMIACETAL, UREA, IMIDAZOLONE P, INFRARED SPECTROPHOTOMETRY, NMR SPECTROMETRY, MASS SPECTROGRAPHY, ELEMENTAL ANALYSIS

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