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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (23): 2709-2713. 上一篇    下一篇

研究论文

几种手性化合物在直链淀粉-三(环己基氨基甲酸酯)手性固定相上高压液相中的拆分

李文智*，杜明霞，徐翠兰，邵 鑫，尹贻彬，赵利民   

  1. (聊城大学材料科学与工程学院 聊城 252059)
  • 投稿日期:2009-07-17 修回日期:2009-11-05 发布日期:2009-11-06
  • 通讯作者: 李文智 E-mail:liwenzhi@lcu.edu.cn,liwzhv008@hotmail.com

Enantioseparation of Chiral Compounds on Amylose-tris(cyclohexylcarbamate) Chiral Stationary Phase by High-performance Liquid Chromatography

Li, Wenzhi*，Du, Mingxia，Xu, Cuilan，Shao, Xin Yin, Yibin，Zhao, Limin   

  1. (College of Materials Science and Engineering, Liaocheng University, Liaocheng 252059)
  • Received:2009-07-17 Revised:2009-11-05 Published:2009-11-06
  • Contact: LI Wen-Zhi E-mail:liwenzhi@lcu.edu.cn,liwzhv008@hotmail.com

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被引次数

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正相条件下, 在自制的涂敷型直链淀粉-三(环己基氨基甲酸酯)手性固定相上, 直接拆分了九种不同类型的手性化合物, 考察了流动相中极性添加剂对手性拆分的影响, 并与直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)进行了比较. 研究发现, 此种手性固定相不仅具有较高的手性识别能力, 而且对某些类型手性化合物的选择性与后者明显不同; 探讨了此种固定相可能的拆分机理.

关键词: 直链淀粉-三(环己基氨基甲酸酯), 高效液相色谱, 手性拆分

Amylose-tris(cyclohexylcarbamate) (ACHC) coated on a kind of small particle silica gel was prepared. On this chiral stationary phase (CSP), the direct enantiomeric separation of nine chiral compounds has been achieved using n-hexane as the mobile phase containing various alcohols as modifiers. The effect of mobile phase modifiers on their resolution and retention was investigated. Chromatographic behavior of chiral compounds on ACHC-CSP was compared with that on amylose-tris(3,5-dimethylphenylcarbamate) by hexane/isopropanol as the mobile phase. The result suggests that ACHC showed high chiral recognition abilities as well as amylose-tris(3,5-dimethylphenylcarbamate) in HPLC. ACHC-CSP is a suitable CSP for the optical resolution of a lot of racemates by HPLC.

Key words: amylose-tris(cyclohexylcarbamate), HPLC, enantioseparation