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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (14): 1421-1426. 上一篇    下一篇

研究论文

基于N-十二酰基-l-脯氨酸为载体的对映异构PVC膜选择性电极的研制

侯静亚，李冰心，杨园园，徐岚*   

  1. (西南大学化学化工学院 发光与实时分析教育部重点实验室 重庆 400715)
  • 投稿日期:2009-11-11 修回日期:2010-02-28 发布日期:2010-03-17
  • 通讯作者: 王亚琼 E-mail:xulan@swu.edu.cn

Enantioselective PVC Membrane Electrode Based on N-Dodecanoyl-l-proline as Chiral Carrier

HOU Jing-Ya, LI Bing-Xin, YANG Yuan-Yuan, XU Lan   

  1. (Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715)
  • Received:2009-11-11 Revised:2010-02-28 Published:2010-03-17

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合成了手性物质N-十二酰基-l-脯氨酸(N-DDO-l-Pro)(脯氨酸, Pro), 作为PVC膜电极的载体, 在PVC膜表面与被测试液中Cu(II)与脯氨酸形成的配合物[Cu(II)(l-Pro)2]或[Cu(II)(d-Pro)2]进行配体交换, 形成[(l-Pro)Cu(II) (N-DDO-l-Pro)]或[(d-Pro)Cu(II)(N-DDO-l-Pro)]配合物. 由于生成的配合物热力学稳定性不同, 电极能优先响应l-Pro, 线性范围10－4～10―1 mol•L－1, 斜率57 mV•dec－1, 检测限3.89×10－5 mol•L－1. 电极能够对脯氨酸进行手性检测, 其对映选择性系数lg为－3.19.

关键词: N-十二酰基-l-脯氨酸, 对映异构PVC膜选择性电极, l-脯氨酸, 配体交换

N-Dodecanoyl-l-proline (N-DDO-l-Pro) was prepared as the chiral selector of PVC membrane electrode. It can undergo ligand exchange with the enantiomeric labile coordination complexes of [Cu(II)(l-Pro)2] or [Cu(II)(d-Pro)2] in the testing solutions and form diastereoisomeric complex [(l-Pro)Cu(II)(N-DDO-l-Pro)] or [(d-Pro)Cu(II)(N-DDO-l-Pro)] on surface of PVC membrane. Due to different thermodynamic stabilities of diastereoisomeric complexes, electrode can preferentially respond to l-proline, exhibiting near Nernstian slope of 57 mV per decade in the concentration range of 1.0×10－4 to 1.0×10－1 mol•L－1. The detection limit is 3.89×10－5 mol•L－1. Moreover, the electrode can detect chiral l-proline with the enantiomeric selectictivity coefficients (lg, －3.19).

Key words: N-dodecanoyl-l-proline, selective PVC membrane electrode, l-proline, ligand exchange