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化学学报
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化学学报 ›› 1982, Vol. 40 ›› Issue (7): 637-647. 上一篇    下一篇

论文

雷公藤中两种新三萜内酯——雷公藤内酯甲和乙的结构

秦国伟1, 杨学敏1, 顾文华1, 王保德1, 陈政雄1, 郭仁贤2, 邵康蔚2   

  1. 1. 中国科学院上海药物研究所;
    2. 福建省皮肤病防治院
  • 投稿日期:1981-03-11 发布日期:2013-06-03
  • 通讯作者: 秦国伟

THE STRUCTURES OF TWO NEW TRITERPENE LACTONES FROM TRIPTERYGIUM WILFORDII——WILFORLIDES A AND B

QIN GUO-WEI1, YANG XUE-MIN1, GU WEN-HUA1, WANG BAO-DE1, CHEN ZHENG-XIONG1, GUO REN-XIAN2, SHAO KANG-WEI2   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1981-03-11 Published:2013-06-03

PDF

540

被引次数

41

从雷公藤(Tripterygiumw wilfordii Hook.f.)根中分到两种oleanane型的新五环三萜内酯——雷公藤内酯甲和乙(wilforlide A和B),经IR,1HNMR,13CNMR,MS等波谱分析和多种衍生物制备及与已知五环三萜oleanolic acid进行化学关联,推定它们分别为3β,22α-dihydroxy-⊿12-oleanen-29-oic acid和3-keto-22α-hydroxy-⊿12-leanen-29-oic acid的C29→C22内酯.

Tripterygiumw wilfordii Hook.f.(Celastraoeae) is widely distributed in South and Southwest China.Rsoently, it is used for the treatment of rheumatic arthritis and erythema lupus in China.In the course of studying:its aotive principles, we obtained two new oleanane-type triterpene lactones, wilforlides A and B, from the roots of this plant.