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化学学报
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化学学报 ›› 1982, Vol. 40 ›› Issue (7): 648-656. 上一篇    下一篇

论文

对称二酮类化合物的徽生物不对称还原——Ⅰ.2-烷基-2-(3’-羰基丁基)-1,3-环戊二酮的不对称还原

周维善1, 黄大中1, 董纪昌2, 王锺麒1   

  1. 1. 中国科学院上海有机化学研究所;
    2. 上海第一医学院药学系
  • 投稿日期:1980-12-31 发布日期:2013-06-03
  • 通讯作者: 周维善

ASYMMETRICAL REDUCTION OF THE SYMMETRICAL DIKETONES BY MICRO-ORGANISM——Ⅰ. ASYMMETRICAL REDUCTION OF 2-ALKYL-2-(3’-OXOBUTYL)-1, 3-CYCLOPENTANEDIONE

ZHOU WEI-SHAN1, HUANG DA-ZHONG1, DONG QI-CHANG2, WANG ZHONG-QI1   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica
  • Received:1980-12-31 Published:2013-06-03

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对称三酮2a,2b经啤酒酵母菌(2.346)不对称还原获得了光学活性化合物6a,6b,6a或6b的苯溶液在中性氧化铝中发生分子内的氧化还原反应而生成光学纯化合物15a及15b.

The optically active intermediates 6(R=CH3, C2H5) for total syntheses of steroidal oral contraceptives was prepared from symmetrical diketones 2 (R=CH3,C2H5 by microbial asymmetrical reduction.Thus 2a and 2b were cultivated with Saccharomyces cerevisirie (2.346) to give optically active products 6a and 6b in 73% and 71% yields respectively.