化学学报 ›› 1980, Vol. 38 ›› Issue (6): 543-550. 上一篇    下一篇

论文

核磁共振INDOR法研究若干单糖分子的构型和构象

徐光漪   

  1. 上海医药工业研究院
  • 投稿日期:1978-11-05 发布日期:2013-06-03

THE APPLICATION OF INDOR IN THE STUDY OF THE CONFIGURATION AND CONFORMATION OF SUGARS IN DMSO SOLUTION

XU GUANG-YI   

  1. Shanghai Institute of Pharmaceutical Industrial Research
  • Received:1978-11-05 Published:2013-06-03

本文用核磁共振谱的INDOR,研究若干单糖在DMSO溶液中的构型和构象。在单糖分子中,除少数质子如差向异构氢(C1—H)外,大多数质子处于相似的化学环境中,相邻者又彼此偶合,在常规核磁共振谱上产生的信号重迭交错,形成峰包,无法一一辨认以确定归属。从木糖、阿拉伯糖、甘露糖、鼠李糖等单糖在DMSO中的1NDOR谱,可间接测得C2~C4上质子的各组谱线,进而获得每一质子的化学位移及偶合常数。用Karplus方程定出相邻碳上质子的两面角及C—H键取向,因而确证这些分子在DMSO中的立体结构。

In this artiele,INDOR method was used to monitor the multiplets of the anome rie protons and the hydroxyl protons of four monosaccharides.The individual peaks of the C2-C4 protons in the overlapped multiplets were detected indirectly to obtain the NMR parameters-chemical shift δ and coupling constant J.By means of the Karplus eduation,the orientations of all the C-H bonds wer) determined.The contigurations and conformations of these sugars derived from INDOR are as follows:β-L-arabinopyranose chair form (4C1);α-L-rhamnopyranose chair form (1C4);α-D-xylopyranose chair form (4C1);α-D-and β-D-mannopyranose chair form (4C1).