化学学报 ›› 2004, Vol. 62 ›› Issue (7): 720-724. 上一篇    下一篇

研究论文

PMBP与氯代苯胺的缩合反应和抑菌活性

杨云1,2, 王瑾玲2, 李爱秀3, 乔艳红2, 缪方明2   

  1. 1. 天津商学院, 天津, 300134;
    2. 天津师范大学化学与生命科学学院, 天津, 300074;
    3. 武警部队医学院, 天津, 300162
  • 投稿日期:2003-06-30 修回日期:2003-10-20 发布日期:2014-02-18
  • 通讯作者: 王瑾玲,E-mail:wangjinling43@eyou.com E-mail:wangjinling43@eyou.com
  • 基金资助:
    天津市自然科学基金(No.003601711)和天津市21世纪青年基金(No.003700711)资助项目.

Condensed Reaction and Antibacterial Activity of Schiff Base from PMBP with Chloroaniline and Its Complexes

YANG Yun1,2, WANG Jin-Ling2, LI Ai-Xiu3, QIAO Yan-Hong2, MIAO Fang-Ming2   

  1. 1. Tianjin Commerce University, Tianjin 300134;
    2. College of Chemical and Life Science, Tianjin Normal University, Tianjin 300074;
    3. Medical College of Armed Police Forces, Tianjin 300162
  • Received:2003-06-30 Revised:2003-10-20 Published:2014-02-18

报道了1-苯基-3-甲基-4-苯甲酰基-吡唑啉-5-酮(PMBP)与邻、间、对氯苯胺和2,4-二氯苯胺发生缩合反应生成的席夫碱配体及其配合物的合成和结构表征.利用量子化学计算方法讨论了该缩合反应的机理.抑菌活性测定结果表明化合物对金黄色葡萄球菌和大肠杆菌均有一定的抑菌活性,其中以钴配合物的抑菌活性最好.

关键词: PMBP, 氯代苯胺, 合成, 结构表征, 抑菌活性

The synthesis, structure characterization and antibacterial activity of Schiff base condensed from PMBP and o-chloroaniline, m-chloroaniline, p-chloroaniline and 2,4-dichloroaniline and their complexes are reported now. The calculation of the quantum chemistry shows the reaction mechanism of the condensation reaction. The antibacterial activity tests indicate that the ligands L1~L4 and their complexes Y1~Y10 have good antibacterial activities against E.coli and S.aureus, in which the Co(Ⅱ) complex is the best.

Key words: PMBP, chloroaniline, synthesis, structure characterization, antibacterial activity