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2012 , Vol. 70 >Issue 02: 207 - 211

DOI: https://doi.org/10.6023/A1103231

研究简报

纳米稀土氧化物/硫酸酯化壳聚糖杂化材料的制备及其抗凝血性能研究

  • 高琦宽 ,
  • 王坤杰 ,
  • 王喜存
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  • a 西北师范大学化学化工学院 兰州 730070;
    b 兰州理工大学石油化工学院 兰州 730050;
    c 甘肃省卫生学校 兰州 730000

收稿日期: 2011-03-23

  修回日期: 2011-09-14

  网络出版日期: 2012-02-25

基金资助

国家自然科学基金(No.21062017);甘肃省自然科学基金(No.1112RJZA006)和甘肃省高分子材料重点实验室和兰州理工大学博士科研启动资助项目.

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Study on Syntheses and Anticoagulant Action of Rare Earth Nano-oxides/TDI-CS Hybrid Materials

  • GAO Qi-Kuan ,
  • WANG Kun-Jie ,
  • WANG Xi-Cun
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  • a College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070;
    b College of Petrochemical Technology, Lanzhou University of Technology, Lanzhou 730050;
    c Gansu Health School, Lanzhou 730000

Received date: 2011-03-23

  Revised date: 2011-09-14

  Online published: 2012-02-25

Supported by

Project supported by the National Natural Science Foundation of China (No.21062017) and Natural Science Foundation of Gansu Province (No. 1112RJZA006);Gansu Key Laboratory of Polymer Materials and Lanzhou University of Technology for Ph.D.

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摘要

利用接枝的方法制备了4 种纳米RE2O3/硫酸酯化壳聚糖杂化材料(Nd2O3-TDI-CS, Eu2O3-TDI-CS, La2O3-TDI-CS, Sc2O3-TDI-CS, TDI=甲苯二异氰酸酯, CS=壳聚糖), 用红外光谱、热重分析和扫描电镜表征了产物, 结果表明壳聚糖接枝于经过活化后的纳米氧化物表面. 抗凝血实验结果和复钙实验结果说明制备的4种杂化材料比纳米稀土氧化物具有更好的抗凝血性能.

关键词： 壳聚糖; 纳米稀土氧化物; 杂化材料; 抗凝血; 复钙

本文引用格式

高琦宽 , 王坤杰 , 王喜存 . 纳米稀土氧化物/硫酸酯化壳聚糖杂化材料的制备及其抗凝血性能研究[J]. 化学学报, 2012 , 70(02) : 207 -211 . DOI: 10.6023/A1103231

Abstract

Four hybrid materials of RE2O3-TDI-CS (TDI=toluene 2,4-diisocyanate, CS=chitosan, RE=Nd, Eu, La, Sc) were prepared by the method of graft. The materials were characterized by infrared spectroscopy, thermogravimetric and scanning electron microscopy, and results showed that the CS was grafted on the surface of rare earth nano-oxides which was modified by TDI. The results of the experiment of anticoagulant and recalcification time showed that the materials have better anticoagulant action than that of RE2O3.

Key words： chitosan (CS); rare earth nano-oxide; hybrid material; anticoagulant; recalcification

参考文献

1 Muzzarelli, R. A. Chitin, Pergamon Press, New York, 1997, pp. 1～37.  

2 Roberts, G. F. Chitin Chemistry, Mac Millian Press, Houndmills, 1992, pp. 1～50.  

3 Jiang, Z.-J.; Wang, Z.-Y.; Hu, X.-Q. Chem. Bioeng. 2008, 12, 57 (in Chinese). (蒋珍菊, 王周玉, 胡星琪, 化学与生物工程, 2008, 12, 57.)

4 Funakoshi, T.; Furushima, K.; Shimada, H. Biochem. Int. 1992, 28, 113.

5 Novikova, N. V.; Lobanova, E. G.; Lebedeva, E. N.; Men'kov, A. A.; Galaktionova, O. V. Farmakol. Toksikol. (Moscow) 1986, 49, 32.

6 Wang, K.-J.; Luan, N.-N.; Song, Y.-M. Acta Chim. Sinica 2009, 67, 1042 (in Chinese). (王坤杰, 栾尼娜, 宋玉民, 化学学报, 2009, 67, 1042.)

7 Dong, Y.-L.; Luan, N.-N.; Wang, H.-Y.; Song, Y.-M. Acta Chim. Sinica 2008, 66, 1497 (in Chinese). (董银龙, 栾尼娜, 王海燕, 宋玉民, 化学学报, 2008, 66, 1497.)

8 Song, Y.-M.; Dong, Y.-L.; Fu, Y.-L.; Yao, K.-L. Acta Chim. Sinica 2007, 65, 678 (in Chinese). (宋玉民, 董银龙, 付云龙, 姚卡玲, 化学学报, 2007, 65, 678.)

9 Wang, X.; Lu, L.-D. Chinese J. Inorg. Chem. 2000, 16, 213 (in Chinese). (汪信, 陆路德, 无机化学学报, 2000, 16, 213.)

10 Liu, P.; Chen, Y.-S.; Zhang, L.-H. J. Funct. Polym. 2004, 17, 35 (in Chinese). (刘鹏, 陈亚芍, 张丽惠, 功能高分子学报, 2004, 17, 35.)

11 Shi, H.-T.; Mo, X.-M.; He, C.-L.; Guo, K.; Liu, S.-H. J. Clin. Rehabilitative Tissue Eng. Res. 2008, 12, 10 (in Chinese). (石海涛, 莫秀梅, 何创龙, 过凯, 刘生和, 中国组织工程 研究与临床康复, 2008, 12, 10.)

12 Nag, M.; Basak, P.; Manorama, S. V. Mater. Res. Bull. 2007, 42, 1691.  

13 Watson, S.; Beydoun, D.; Scott, J.; Amal, R. J. Nanopart. Res. 2004, 6, 193.  

14 Li, H. R.; Lin, J.; Zhang, H. J.; Fu, L. S.; Meng, Q. G.; Wang, S. B. Chem. Mater. 2002, 14, 3651.  

15 Lei, X. P.; Su, Z. X. Polym. Adv. Technol. 2007, 18, 472.  

16 Wang, Q.; Ni, J.-Z. Chem. J. Chin. Univ. 2004, 25, 1783 (in Chinese). (王群, 倪嘉缵, 高等学校化学学报, 2004, 25, 1783.)
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