 |
李真, 中国科学技术大学应用化学与工程学院在读研究生. 2018年进入南海海洋资源利用国家重点实验室进行研究学习; 2020年本科毕业于海南大学材料科学与工程学院; 同年进入中国科学技术大学, 攻读硕士学位; 2021年3月进入中国科学院长春应用化学研究所生态环境高分子材料重点实验室进行研究学习. 主要研究方向是生物医用材料的合成及其在炎症疾病治疗中的应用. |
 |
陈杰, 副研究员, 博士. 2006年本科毕业于大连理工大学, 2013年于中国科学院大学获得硕士学位, 2021年于中国科学技术大学获得博士学位, 现为中国科学院长春应用化学研究所生态环境高分子材料重点实验室副研究员. 主要从事高分子基因/药物材料的制备及其在重大疾病治疗中的研究. |
 |
田华雨, 博士生导师, 国家杰出青年基金获得者. 1998年本科毕业于哈尔滨工业大学, 2000年于哈尔滨工业大学获得硕士学位, 2006年于中国科学院长春应用化学研究所获得博士学位, 现为中国科学院长春应用化学研究所生态环境高分子材料重点实验室研究员. 主要从事新型生物医用高分子材料的研究. |
 |
陈学思, 博士生导师, 中国科学院院士, 国家杰出青年基金获得者. 1982年本科毕业于吉林大学, 1988年于中国科学院长春应用化学研究所获得硕士学位, 1997年于日本早稻田大学获得博士学位. 1997年5月~1999年5月美国宾夕法尼亚大学博士后, 1999年6月起在中国科学院长春应用化学研究所任研究员. 主要从事生物医用高分子材料的制备及应用研究. |
收稿日期: 2021-12-31
网络出版日期: 2022-02-17
基金资助
国家科技部重点研发计划(2021YFB3800900); 国家自然科学基金(51925305); 国家自然科学基金(51873208); 国家自然科学基金(51833010); 国家自然科学基金(51973217); 吉林省科技发展(20200201075JC)
Sepsis Treatment Strategies Based on Nanomaterials※
Received date: 2021-12-31
Online published: 2022-02-17
Supported by
National Key Research and Development Program of China(2021YFB3800900); National Natural Science Foundation of China(51925305); National Natural Science Foundation of China(51873208); National Natural Science Foundation of China(51833010); National Natural Science Foundation of China(51973217); Jilin Province Science and Technology Development Program(20200201075JC)
李真 , 陈杰 , 田华雨 , 陈学思 . 基于纳米材料的脓毒症治疗策略※[J]. 化学学报, 2022 , 80(5) : 668 -678 . DOI: 10.6023/A21120615
Sepsis is a life-threatening disease caused by a dysregulated host response to infection. Its pathogenesis is complex, and despite some advances in recent years, the mortality rate is still 25% to 30%. Sepsis treatment based on nanomaterials can be constructed for the purpose of eliminating infection sources and eliminating inflammation, which is an effective tool to fight sepsis. In this paper, the latest progress in the treatment of sepsis based on nanomaterials is reviewed. From the perspective of its pathogenesis, the nanomaterials for the treatment of sepsis based on antibacterial, scavenging of reactive oxygen species, and scavenging of dangerous molecules is reviewed in detail. And the problems and challenges facing the potential treatment in the future are discussed. The new challenges facing the treatment of sepsis using nanomaterials are also discussed in the hope to provide new ideas and solutions for sepsis treatment.
Key words： sepsis; immune dysfunction; inflammation; nanomaterials; infection
| [1] | Singer, M.; Deutschman, C. S.; Seymour, C. W.; Shankar-Hari, M.; Annane, D.; Bauer, M.; Bellomo, R.; Bernard, G. R.; Chiche, J. D.; Coopersmith, C. M.; Hotchkiss, R. S.; Levy, M. M.; Marshall, J. C.; Martin, G. S.; Opal, S. M.; Rubenfeld, G. D.; van der Poll, T.; Vincent, J. L.; Angus, D. C. JAMA 2016, 315, 801. |
| [2] | Fleischmann, C.; Scherag, A.; Adhikari, N. K.; Hartog, C. S.; Tsaganos, T.; Schlattmann, P.; Angus, D. C.; Reinhart, K. Am. J. Respir. Crit. Care Med. 2016, 193, 259. |
| [3] | Coopersmith, C. M.; De Backer, D.; Deutschman, C. S.; Ferrer, R.; Lat, I.; Machado, F. R.; Martin, G. S.; Martin-Loeches, I.; Nunnally, M.E.; Antonelli, M.; Evans, L.E.; Hellman, J.; Jog, S.; Kesecioglu, J.; Levy, M. M.; Rhodes, A. Crit. Care Med. 2018, 46, 1334. |
| [4] | Rudd, K. E.; Johnson, S. C.; Agesa, K. M.; Shackelford, K. A.; Tsoi, D.; Kievlan, D. R.; Colombara, D. V.; Ikuta, K. S.; Kissoon, N.; Finfer, S.; Fleischmann-Struzek, C.; Machado, F. R.; Reinhart, K. K.; Rowan, K.; Seymour, C. W.; Watson, R. S.; West, T. E.; Marinho, F.; Hay, S. I.; Lozano, R.; Lopez, A. D.; Angus, D. C.; Murray, C. J. L.; Naghavi, M. Lancet 2020, 395, 200. |
| [5] | Gyawali, B.; Ramakrishna, K.; Dhamoon, A.S. SAGE Open Med. 2019, 7, 1. |
| [6] | Liu, Y.-X.; Xiang, H.-L. J. Trauma Surg. 2021, 23, 865. (in Chinese) |
| [6] | (刘玉新, 向弘利, 创伤外科杂志, 2021, 23, 865.) |
| [7] | Zou, H.; Qian, H.-B.; Zhao, H.-S. Chin. J. Crit Care Intensive Care Med. 2020, 6, 453. (in Chinese) |
| [7] | (邹晗, 钱何布, 赵宏胜, 中华重症医学电子杂志(网络版), 2020, 6, 453.) |
| [8] | Xia, W.-F.; Li, B.-Y.; Lin, W.-S.; Pan, Z.; Deng, Z.-M.; Zhang, Y.-G. Med. Recapitulate 2019, 25, 2169. (in Chinese) |
| [8] | (夏文芳, 李冰玉, 林维山, 潘舟, 邓志敏, 张勇刚, 医学综述, 2019, 25, 2169.) |
| [9] | Morton, B.; Stolbrink, M.; Kagima, W.; Rylance, J.; Mortimer, K. Int. J. Environ. Res. Public Health 2018, 15, 9. |
| [10] | Zhao, Y.; Pu, M.; Zhang, J.; Wang, Y.; Yan, X.; Yu, L.; He, Z. Nanoscale 2021, 13, 10726. |
| [11] | Luo, G.; Zhang, J.; Sun, Y.; Wang, Y.; Wang, H.; Cheng, B.; Shu, Q.; Fang, X. Nanomicro Lett. 2021, 13, 88. |
| [12] | Li, D.; Wu, M. Signal Transduct Target Ther. 2021, 6, 291. |
| [13] | Chen, L.; Huang, Q.; Zhao, T.; Sui, L.; Wang, S.; Xiao, Z.; Nan, Y.; Ai, K. Redox Biol. 2021, 45, 102046. |
| [14] | Lelubre, C.; Vincent, J. L. Nat. Rev. Nephrol. 2018, 14, 417. |
| [15] | Van der Poll, T.; Shankar-Hari, M.; Wiersinga, W. J. Immunity 2021, 54, 2450. |
| [16] | Forstermann, U.; Sessa, W. C. Eur. Heart. J. 2012, 33, 829. |
| [17] | Lim, J.; Lee, Y. Y.; Choy, Y. B.; Park, W.; Park, C. G. Open Biomed. Eng. Lett. 2021, 11, 197. |
| [18] | Thurairajah, K.; Briggs, G. D.; Balogh, Z. J. Eur. J. Trauma Emerg. Surg. 2018, 44, 325. |
| [19] | Bhagirath, V. C.; Dwivedi, D. J.; Liaw, P. C. Shock 2015, 44, 265. |
| [20] | Jackson Chornenki, N. L.; Coke, R.; Kwong, A. C.; Dwivedi, D. J.; Xu, M. K.; McDonald, E.; Marshall, J. C.; Fox-Robichaud, A. E.; Charbonney, E.; Liaw, P. C. Intensive Care Med. Exp. 2019, 7, 29. |
| [21] | Kamaly, N.; Yameen, B.; Wu, J.; Farokhzad, O. C. Chem. Rev. 2016, 116, 2602. |
| [22] | Wu, J.; Kamaly, N.; Shi, J.; Zhao, L.; Xiao, Z.; Hollett, G.; John, R.; Ray, S.; Xu, X.; Zhang, X.; Kantoff, P. W.; Farokhzad, O. C. Angew. Chem., Int. Ed. Eng. 2014, 53, 8975. |
| [23] | Rifkind, D. J. Bacteriol. 1967, 93, 1463. |
| [24] | Huang, C.; Xiao, Y.-H. Her. Med. 2020, 39, 10. (in Chinese) |
| [24] | (黄晨, 肖永红, 医药导报, 2020, 39, 10.) |
| [25] | Yang, X.; Ren, H.; Zhang, H.; Liu, G.; Jiang, Z.; Qiu, Q.; Yu, C.; Murthy, N.; Zhao, K.; Lovell, J. F.; Zhang, Y. ACS Appl. Mater. Interfaces 2021, 13, 9630. |
| [26] | Qi, Y.; Ren, S.; Che, Y.; Ye, J.; Ning, G. Acta Chim. Sinica 2020, 78, 642. (in Chinese) |
| [26] | (齐野, 任双颂, 车颖, 叶俊伟, 宁桂玲, 化学学报, 2020, 78, 642.) |
| [27] | Ma, J.; Zhang, J.; Chi, L.; Liu, C.; Li, Y.; Tian, H. Chin. Chem. Lett. 2020, 31, 1427. |
| [28] | Zhang, X.; Zhang, Z.; Shu, Q.; Xu, C.; Zheng, Q.; Guo, Z.; Wang, C.; Hao, Z.; Liu, X.; Wang, G.; Yan, W.; Chen, H.; Lu, C. Adv. Funct. Mater. 2021, 31, 2008720. |
| [29] | Liu, W.; Tao, Z.; Wang, D.; Liu, Q.; Wu, H.; Lan, S.; Dong, A. Chem. Eng. J. 2021, 415, 128888. |
| [30] | Zhang, C. Y.; Gao, J.; Wang, Z. Adv. Mater. 2018, 30, e1803618. |
| [31] | Zhang, L.; Chen, Q.; Wang, J. Acta Chim. Sinica 2020, 78, 613. (in Chinese) |
| [31] | (张留伟, 陈麒先, 王静云, 化学学报, 2020, 78, 613.) |
| [32] | Yim, D.; Lee, D. E.; So, Y.; Choi, C.; Son, W.; Jang, K.; Yang, C. S.; Kim, J. H. ACS Nano 2020, 14, 10324. |
| [33] | Chen, X.; Zhu, X.; Gong, Y.; Yuan, G.; Cen, J.; Lie, Q.; Hou, Y.; Ye, G.; Liu, S.; Liu, J. Appl. Mater. Today 2021, 22, 100929. |
| [34] | Rajendrakumar, S. K.; Revuri, V.; Samidurai, M.; Mohapatra, A.; Lee, J. H.; Ganesan, P.; Jo, J.; Lee, Y.-K.; Park, I.-K. Nano Lett. 2018, 18, 6417. |
| [35] | Kumar, V. Int. Immunopharmacol. 2020, 89, 107087. |
| [36] | Gabarin, R. S.; Li, M.; Zimmel, P. A.; Marshall, J. C.; Li, Y.; Zhang, H. J. Innate Immun. 2021, 13, 323. |
| [37] | Yuk, S. A.; Kim, H.; Abutaleb, N. S.; Dieterly, A. M.; Taha, M. S.; Tsifansky, M. D.; Lyle, L. T.; Seleem, M. N.; Yeo, Y. Sci. Adv. 2021, 7, eabj1577. |
| [38] | Shen, S.; Han, F.; Yuan, A.; Wu, L.; Cao, J.; Qian, J.; Qi, X.; Yan, Y.; Ge, Y. Biomaterials 2019, 189, 60. |
| [39] | Jiang, L.; Li, R.; Xu, J.; Luan, P.; Cui, Q.; Pang, Z.; Wang, J.; Lin, G.; Zhang, J. Chem. Eng. J. 2019, 371, 15. |
| [40] | Jiang, L.; Zhu, Y.; Luan, P.; Xu, J.; Ru, G.; Fu, J.G.; Sang, N.; Xiong, Y.; He, Y.; Lin, G.Q.; Wang, J.; Zhang, J.; Li, R. ACS Nano 2021, 15, 4173. |
| [41] | Gollomp, K.; Sarkar, A.; Harikumar, S.; Seeholzer, S. H.; Arepally, G. M.; Hudock, K.; Rauova, L.; Kowalska, M. A.; Poncz, M. Blood 2020, 135, 743. |
| [42] | Hu, Y.-Y.; Lin, L.; Guo, Z.-P.; Chen, J.; Maruyama, A.; Tian, H.-Y.; Chen, X.-S. Chin. Chem. Lett. 2021, 32, 1770. |
| [43] | Liu, F.; Sheng, S.; Shao, D.; Xiao, Y.; Zhong, Y.; Zhou, J.; Quek, C. H.; Wang, Y.; Hu, Z.; Liu, H.; Li, Y.; Tian, H.; Leong, K. W.; Chen, X. Nano Lett. 2021, 21, 2461. |
| [44] | Dawulieti, J.; Sun, M.; Zhao, Y.; Shao, D.; Yan, H.; Lao, Y.-H.; Hu, H.; Cui, L.; Lv, X.; Liu, F. Sci. Adv. 2020, 6, eaay7148. |
| [45] | Hao, K.; Guo, Z.-P.; Lin, L.; Sun, P.-J.; Li, Y.-H.; Tian, H.-Y.; Chen, X.-S. Sci. China Chem. 2021, 64, 1235. |
| [46] | Xu, C.-N.; Tian, H.-Y.; Chen, X.-S. Sci. China Chem. 2017, 60, 319. |
| [47] | Lin, L.; Guo, Z.-P.; Chen, J.; Tian, H.-Y.; Chen, X.-S. Acta Polym. Sin. 2017, (2), 321.. (in Chinese) |
| [47] | (林琳, 郭兆培, 陈杰, 田华雨, 陈学思, 高分子学报, 2017, (2), 321.) |
| [48] | Guo, Z.-P.; Lin, L.; Chen, J.; Tian, H.-Y.; Chen, X.-S. Chem. J. Chin. Univ. 2020, 41, 235. (in Chinese) |
| [48] | (郭兆培, 林琳, 陈杰, 田华雨, 陈学思, 高等学校化学学报, 2020, 41, 235.) |
| [49] | Xia, J.-L.; Tian, H.-Y.; Chen, J.; Guo, Z.-P.; Lin, L.; Yang, H.-Y.; Feng, Z.-C. Chin. J. Polym. Sci. 2016, 34, 316. |
| [50] | Koide, H.; Okishima, A.; Hoshino, Y.; Kamon, Y.; Yoshimatsu, K.; Saito, K.; Yamauchi, I.; Ariizumi, S.; Zhou, Y.; Xiao, T.H.; Goda, K.; Oku, N.; Asai, T.; Shea, K. J. Nat. Commun. 2021, 12, 5552. |
| [51] | Park, H. H.; Kim, H.; Lee, H. S.; Seo, E. U.; Kim, J. E.; Lee, J. H.; Mun, Y. H.; Yoo, S. Y.; An, J.; Yun, M. Y.; Kang, N. W.; Kim, D. D.; Na, D. H.; Hong, K. S.; Jang, J. G.; Ahn, J. H.; Bae, J. S.; Song, G. Y.; Lee, J. Y.; Kim, H. N.; Lee, W. Biomaterials 2021, 273, 120827. |
| [52] | Liu, F.; Sheng, S.; Shao, D.; Xiao, Y.; Zhong, Y.; Zhou, J.; Quek, C.H.; Wang, Y.; Dawulieti, J.; Yang, C.; Tian, H.; Chen, X.; Leong, K. W. Matter 2021, 4, 3677. |
| [53] | Kim, H. N.; Park, H. H.; Lim, W.; Hong, K. S.; Ahn, J. H.; Na, D. H.; Kim, I. S.; Jang, J. G.; Bae, J. S.; Lee, W. Adv. Funct. Mater. 2020, 30, 2006110. |
| [54] | Wang, S.; Lai, X.; Li, C.; Chen, M.; Hu, M.; Liu, X.; Song, Y.; Deng, Y. J. Control. Release 2021, 337, 612. |
| [55] | Hou, X.; Zhang, X.; Zhao, W.; Zeng, C.; Deng, B.; McComb, D. W.; Du, S.; Zhang, C.; Li, W.; Dong, Y. Nat. Nanotechnol. 2020, 15, 41. |
| [56] | Chen, H.; Gu, Z.; An, H.; Chen, C.; Chen, J.; Cui, R.; Chen, S.; Chen, W.; Chen, X.; Chen, X.; Chen, Z.; Ding, B.; Dong, Q.; Fan, Q.; Fu, T.; Hou, D.; Jiang, Q.; Ke, H.; Jiang, X.; Liu, G.; Li, S.; Li, T.; Liu, Z.; Nie, G.; Ovais, M.; Pang, D.; Qiu, N.; Shen, Y.; Tian, H.; Wang, C.; Wang, H.; Wang, Z.; Xu, H.; Xu, J.-F.; Yang, X.; Zhu, S.; Zheng, X.; Zhang, X.; Zhao, Y.; Tan, W.; Zhang, X.; Zhao, Y. Science China Chemistry 2018, 61, 1503. |
| [57] | Xu, C.-N.; Tian, H.-Y.; Wang, Y.-B.; Du, Y.; Chen, J.; Lin, L.; Guo, Z.-P.; Chen, X.-S. Chin. Chem. Lett. 2017, 28, 807. |
| [58] | Zhang, Y.; Liu, L.; Wang, T.-H.; Tian, H.-Y.; Chen, X.-S. Acta Polym. Sin. 2017, (7), 1150. (in Chinese) |
| [58] | (张滢, 刘梁, 王庭宏, 田华雨, 陈学思, 高分子学报, 2017, (7), 1150.) |
| [59] | Feng, T.-S.; Tian, H.-Y.; Xu, C.-N.; Lin, L.; Lam, M.H.-W.; Liang, H.-J.; Chen, X.-S. Chin. J. Polym. Sci. 2015, 33, 947. |
| [60] | Gao, W.; Sun, L.-Y.; Wang, L.; Wang, K.; Li, Q.; Yang, H. J. Shanghai Jiaotong Univ., Med. Sci. 2018, 38, 889. (in Chinese) |
| [60] | (高炜, 孙立亚, 王璐, 王琨, 李强, 杨红, 上海交通大学学报(医学版), 2018, 38, 889.) |
| [61] | Jiao, Z.-X.; Chen, J.; Tian, H.-Y.; Chen, X.-S. Acta Polym. Sin. 2015, (1), 127. (in Chinese) |
| [61] | (焦自学, 陈杰, 田华雨, 陈学思, 高分子学报, 2015, (1), 127.) |
| [62] | Chen, J.; Jiao, Z.-X.; Lin, L.; Guo, Z.-P.; Xu, C.-N.; Li, Y.-H.; Tian, H.-Y.; Chen, X.-S. Chin. J. Polym. Sci. 2015, 33, 830. |
| [63] | Zhao, H.; Lv, X.; Huang, J.; Huang, S.; Zhou, H.; Wang, H.; Xu, Y.; Wang, J.; Wang, J.; Liu, Z. Biomaterials 2021, 277, 121106. |
/
| 〈 |
|
〉 |
