Acta Chim. Sinica ›› 2018, Vol. 76 ›› Issue (11): 831-837.DOI: 10.6023/A18060232 Previous Articles     Next Articles

Special Issue: 有机小分子-金属协同催化



鲁鸿a,b, 刘金宇b, 李红玉a, 许鹏飞b   

  1. a. 兰州大学 微生物学研究所 生命科学学院 兰州 730000;
    b. 兰州大学 功能有机分子化学国家重点实验室 化学化工学院 兰州 730000
  • 投稿日期:2018-06-14 发布日期:2018-07-19
  • 通讯作者: 许鹏飞
  • 作者简介:鲁鸿博士于2010年在兰州大学获得学士学位.同年保送研究生,2015年在兰州大学获得博士学位,导师许鹏飞教授.;刘金宇,2014年本科毕业于兰州大学,保送研究生,2014年至今师从许鹏飞教授攻读理学博士学位;李红玉,兰州大学教授,1993年于兰州大学获得理学硕士学位,1996年于南京农业大学获得理学博士学位,同年进入兰州大学博士后流动站从事博士后研究,出站后留兰州大学生命科学学院、药学院工作;许鹏飞,兰州大学教授.1998年于兰州大学化学系获得理学博士学位.
  • 基金资助:


Recent Developments in N-Heterocyclic Carbene and Transition-Metal Cooperative Catalysis

Lu Honga,b, Liu Jin-Yub, Li Hong-Yua, Xu Peng-Feib   

  1. a. Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000;
    b. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000
  • Received:2018-06-14 Published:2018-07-19
  • Contact: 10.6023/A18060232
  • About author:鲁鸿博士于2010年在兰州大学获得学士学位.同年保送研究生,2015年在兰州大学获得博士学位,导师许鹏飞教授.;刘金宇,2014年本科毕业于兰州大学,保送研究生,2014年至今师从许鹏飞教授攻读理学博士学位;李红玉,兰州大学教授,1993年于兰州大学获得理学硕士学位,1996年于南京农业大学获得理学博士学位,同年进入兰州大学博士后流动站从事博士后研究,出站后留兰州大学生命科学学院、药学院工作;许鹏飞,兰州大学教授.1998年于兰州大学化学系获得理学博士学位.
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21632003, 21572087), Key Program of Gansu Province (Nos. 17ZD2GC011), and the "111" Program from the MOE of P. R. China.

Recently, N-heterocyclic carbene (NHC) catalysis has achieved significant achievement in the field of cooperative catalysis. With the combination of other established catalysis modes (e.g., Lewis acid, Brønsted acid/base, hydrogen-bond donor), great improvement has been made in the enhancement of reactivity and stereoselectivity, and this strategy has emerged as a powerful instrument in organic synthesis to construct complex molecules. However, owing to the strong propensity of NHCs to bind to transition metals, the development of cooperative catalysis of NHCs and transition metals remains a longstanding and challenging work. At present, some important progress has been made in the combination of NHCs with palladium, copper and ruthenium, and the coordination of NHCs and transition metals can be controlled by the modulation of ligand and alkalinity in reaction system, which not only avoiding the deactivation of the catalysts, but also improving the reaction activity efficiently. This strategy has also been used in the asymmetric construction of bioactive molecular scaffolds. In this perspective, the achievements on NHC and transition metals cooperative catalysis will be discussed.

Key words: N-heterocyclic carbene, transition-metal catalysis, cooperative catalysis, asymmetric catalysis, organocatalysis