Sepsis Treatment Strategies Based on Nanomaterials※

doi:10.6023/A21120615

Acta Chimica Sinica ›› 2022, Vol. 80 ›› Issue (5): 668-678.DOI: 10.6023/A21120615 Previous Articles Next Articles

Special Issue: 中国科学院青年创新促进会合辑

Review

基于纳米材料的脓毒症治疗策略^※

李真^a^,^b, 陈杰^a, 田华雨^a^,^b^,^*(), 陈学思^a^,^b

a 中国科学院长春应用化学研究所生态环境高分子材料重点实验室长春 130022
b 中国科学技术大学应用化学与工程学院合肥 230026

投稿日期:2021-12-31 发布日期:2022-02-17
通讯作者: 田华雨

作者简介:

李真, 中国科学技术大学应用化学与工程学院在读研究生. 2018年进入南海海洋资源利用国家重点实验室进行研究学习; 2020年本科毕业于海南大学材料科学与工程学院; 同年进入中国科学技术大学, 攻读硕士学位; 2021年3月进入中国科学院长春应用化学研究所生态环境高分子材料重点实验室进行研究学习. 主要研究方向是生物医用材料的合成及其在炎症疾病治疗中的应用.

陈杰, 副研究员, 博士. 2006年本科毕业于大连理工大学, 2013年于中国科学院大学获得硕士学位, 2021年于中国科学技术大学获得博士学位, 现为中国科学院长春应用化学研究所生态环境高分子材料重点实验室副研究员. 主要从事高分子基因/药物材料的制备及其在重大疾病治疗中的研究.

田华雨, 博士生导师, 国家杰出青年基金获得者. 1998年本科毕业于哈尔滨工业大学, 2000年于哈尔滨工业大学获得硕士学位, 2006年于中国科学院长春应用化学研究所获得博士学位, 现为中国科学院长春应用化学研究所生态环境高分子材料重点实验室研究员. 主要从事新型生物医用高分子材料的研究.

陈学思, 博士生导师, 中国科学院院士, 国家杰出青年基金获得者. 1982年本科毕业于吉林大学, 1988年于中国科学院长春应用化学研究所获得硕士学位, 1997年于日本早稻田大学获得博士学位. 1997年5月~1999年5月美国宾夕法尼亚大学博士后, 1999年6月起在中国科学院长春应用化学研究所任研究员. 主要从事生物医用高分子材料的制备及应用研究.

^※庆祝中国科学院青年创新促进会十年华诞.

基金资助:
国家科技部重点研发计划(2021YFB3800900); 国家自然科学基金(51925305); 国家自然科学基金(51873208); 国家自然科学基金(51833010); 国家自然科学基金(51973217); 吉林省科技发展(20200201075JC)

Sepsis Treatment Strategies Based on Nanomaterials^※

Zhen Li^a^,^b, Jie Chen^a, Huayu Tian^a^,^b(), Xuesi Chen^a^,^b

a Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022
b School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026

Received:2021-12-31 Published:2022-02-17
Contact: Huayu Tian
About author:
^※ Dedicated to the 10th anniversary of the Youth Innovation Promotion Association, CAS.
Supported by:
National Key Research and Development Program of China(2021YFB3800900); National Natural Science Foundation of China(51925305); National Natural Science Foundation of China(51873208); National Natural Science Foundation of China(51833010); National Natural Science Foundation of China(51973217); Jilin Province Science and Technology Development Program(20200201075JC)

Sepsis is a life-threatening disease caused by a dysregulated host response to infection. Its pathogenesis is complex, and despite some advances in recent years, the mortality rate is still 25% to 30%. Sepsis treatment based on nanomaterials can be constructed for the purpose of eliminating infection sources and eliminating inflammation, which is an effective tool to fight sepsis. In this paper, the latest progress in the treatment of sepsis based on nanomaterials is reviewed. From the perspective of its pathogenesis, the nanomaterials for the treatment of sepsis based on antibacterial, scavenging of reactive oxygen species, and scavenging of dangerous molecules is reviewed in detail. And the problems and challenges facing the potential treatment in the future are discussed. The new challenges facing the treatment of sepsis using nanomaterials are also discussed in the hope to provide new ideas and solutions for sepsis treatment.

Key words: sepsis, immune dysfunction, inflammation, nanomaterials, infection

Cite this article

Zhen Li, Jie Chen, Huayu Tian, Xuesi Chen. Sepsis Treatment Strategies Based on Nanomaterials^※[J]. Acta Chimica Sinica, 2022, 80(5): 668-678.

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Fig. & Tab. 8

Figure 1. Synthesis of PMB cross-linked micelles (A) and its application in the treatment of sepsis (B)[25]. Copyright (2021) American Chemical Society

Figure 2. Structures of biocompatible TMD nanosheets and its principle of removing reactive oxygen species[32]. Copyright (2020) American Chemical Society

Figure 3. Schematic representation on formulation of antioxidant nanomaterials mSPAM and its role in inducing anti-inflammation in LPS induced sepsis[34]. Copyright (2018) American Chemical Society

Figure 4. Red blood cell-mimetic hybrid liposome can be used for the adsorption of a variety of toxins[40]. Copyright (2021) American Chemical Society

Figure 5. (a) Preparation of PEI-g-ZIF NPs and (b) sepsis treatment by cfDNA scavenging by PEI-g-ZIF NPs[43]. Copyright (2021) American Chemical Society

Figure 6. (a) Synthesis of HNPs which can neutralize histones and (b) its therapeutic mechanisms for sepsis[50]. Copyright (2021) American Chemical Society

Figure 7. (a) Schematic illustration of selective LPS and (b) cytokine removal by multifunctional NT[34]. Copyright (2020) Springer Nature

Figure 8. (a) Schematic illustration of TA-Zn-Gen NPs with clearance of multiple inflammatory mediators and (b) treatment of TA-Zn-Gen NPs for sepsis[52]. Copyright (2021) Elsevier

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基于纳米材料的脓毒症治疗策略^※

Sepsis Treatment Strategies Based on Nanomaterials^※

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基于纳米材料的脓毒症治疗策略※

Sepsis Treatment Strategies Based on Nanomaterials※

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基于纳米材料的脓毒症治疗策略^※

Sepsis Treatment Strategies Based on Nanomaterials^※