Biosensing Technology for Dengue Virus Detection

doi:10.6023/A21080410

Acta Chimica Sinica ›› 2022, Vol. 80 ›› Issue (1): 69-79.DOI: 10.6023/A21080410 Previous Articles Next Articles

Account

登革热病毒检测的生物传感技术

师瑶^a^,^b, 夏乾峰^a, 何政清^a^,^b, 鞠熀先^b^,^*()

^a海南医学院热带医学与检验医学学院热带转化医学教育部重点实验室海口 571199
^b南京大学化学化工学院生命分析化学国家重点实验室南京 210023

投稿日期:2021-08-29 发布日期:2021-10-22
通讯作者: 鞠熀先

作者简介:

师瑶, 2020年本科毕业于海南医学院热带医学与检验医学院, 2020~2023年为海南医学院热带医学与检验医学院硕士研究生, 主要从事热带病检测方法的研究.

夏乾峰, 临床检验诊断学博士, 教授, 博士生导师. 现任海南医学院热带医学与检验医学院常务副院长(主持工作), 中华医学会热带病与寄生虫学专业委员会秘书长、海南省医学会热带病与寄生虫专业委员会主委、中国医检整合联盟常务理事、中国空间微生物学会委员、海南省微生物学会副理事长等. 研究方向为临床检验新方法和热带病防控关键技术. 主持传染病国家重大科技专项、海南省重大科技专项课题各1项、国家自然科学基金3项. 以第一或通讯作者发表论文50余篇(SCI收录28篇), 获海南省科技进步二等奖1项, 四川省科技进步二等奖1项, 海南省教学成果二等奖3项, 研发的新冠抗体检测试剂盒获欧盟CE认证, 并出口欧洲.

何政清, 2016年本科毕业于赣南医学院临床医学院, 2017~2020年为海南医学院基础医学院硕士研究生, 主要从事病原微生物核酸检测的研究.

鞠熀先, 1986、1989和1992年分别获南京大学理学学士、硕士和博士学位, 后留校任教, 1993年为副教授, 1999年聘为教授、博士生导师. 2003年获国家杰出青年科学基金, 2007年遴选为“长江学者”特聘教授, 2005~2014年主持国家自然科学基金创新研究群体项目、2009~2014年主持“973”计划项目. 现为生命分析国家重点实验室主任、国际电化学会会士、英国皇家化学会会士. 研究方向为分子诊断与生物分析化学, 主要研究领域为免疫分析、细胞分析化学、纳米生物传感和临床分子诊断, 至2021年10月, 发表论文772篇; 英文专著6部, 中文专著、教材7部, 专章20篇; SCI刊物他引35000多次, h-index为99 (Google Scholar h-index为107, 引用42000多次).

基金资助:
项目受国家自然科学基金(21635005); 项目受国家自然科学基金(21827812); 项目受国家自然科学基金(21890741)

Biosensing Technology for Dengue Virus Detection

Yao Shi^a^,^b, Qianfeng Xia^a, Zhengqing He^a^,^b, Huangxian Ju^b()

^aKey Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou 571199, China
^bState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Received:2021-08-29 Published:2021-10-22
Contact: Huangxian Ju
Supported by:
National Natural Science Foundation of China(21635005); National Natural Science Foundation of China(21827812); National Natural Science Foundation of China(21890741)

Dengue virus is a single-stranded RNA virus transmitted by mosquitoes, belonging to the flaviviridae. Currently, there are no targeted antiviral drugs and effective virus vaccines of timely prevention. Due to the importance of clinical detection, new methods for detecting Dengue virus infection have emerged in recent years, trying to detect and control this infection early. This review mainly describes the biosensing technologies for the detection of Dengue virus related diagnostic markers, including optical, electrochemical, enzyme-linked immunosorbent assay and other biosensing methods, and comprehensively evaluates the sensitivity, accuracy, concentration range, detection limit and clinical application ability of different detection methods, so as to further improve the detection performance of these technologies, and to promote the development of this field. It will provide references for the early diagnosis of Dengue virus infection.

Key words: Dengue virus, early infection, biosensor, detection technology, early diagnosis, nucleic acid test

Cite this article

Yao Shi, Qianfeng Xia, Zhengqing He, Huangxian Ju. Biosensing Technology for Dengue Virus Detection[J]. Acta Chimica Sinica, 2022, 80(1): 69-79.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

Fig. & Tab. 12

References 140

[1]	Castro, M. C.; Wilson, M. E.; Bloom, D. E. Lancet Infect. Dis. 2017, 17, e70. doi: 10.1016/S1473-3099(16)30545-X
[2]	Chong, H. Y.; Leow, C. Y.; Abdul Majeed, A. B.; Leow, C. H. Virus Res. 2019, 274, a197770.
[3]	Khristunova, E.; Dorozhko, E.; Korotkova, E.; Kratochvil, B.; Vyskocil, V.; Barek, J. Sensors 2020, 20, 4600. doi: 10.3390/s20164600
[4]	Guzman, M. G.; Gubler, D. J.; Izquierdo, A.; Martinez, E.; Halstead, S. B. Nat. Rev. Dis. Primers 2016, 2, 16055. doi: 10.1038/nrdp.2016.55
[5]	Castillo Signor, L. D. C.; Edwards, T.; Escobar, L. E.; Mencos, Y.; Matope, A.; Castaneda Guzman, M.; Adams, E. R.; Cuevas, L. E. PLoS Negl. Trop. Dis. 2020, 14, e0008535. doi: 10.1371/journal.pntd.0008535
[6]	Li, G. H.; Ning, Z. J.; Liu, Y. M.; Li, X. H. Front. Cell. Infect. Mi. 2017, 7, 449.
[7]	Bhatt, S.; Gething, P. W.; Brady, O. J.; Messina, J. P.; Farlow, A. W.; Moyes, C. L.; Drake, J. M.; Brownstein, J. S.; Hoen, A. G.; Sankoh, O.; Myers, M. F.; George, D. B.; Jaenisch, T.; Wint, G. R.; Simmons, C. P.; Scott, T. W.; Farrar, J. J.; Hay, S. I. Nature 2013, 496, 504. doi: 10.1038/nature12060
[8]	Brady, O. J.; Gething, P. W.; Bhatt, S.; Messina, J. P.; Brownstein, J. S.; Hoen, A. G.; Moyes, C. L.; Farlow, A. W.; Scott, T. W.; Hay, S. I. PLoS Negl. Trop. Dis. 2012, 6, e1760. doi: 10.1371/journal.pntd.0001760
[9]	Banu, S.; Hu, W.; Guo, Y.; Naish, S.; Tong, S. PLoS One 2014, 9, e89440. doi: 10.1371/journal.pone.0089440
[10]	Supadmi, W.; Suwantika, A. A.; Perwitasari, D. A.; Abdulah, R. Value Health 2019, 18, 132.
[11]	Shepard, D. S.; Undurraga, E. A.; Halasa, Y. A.; Stanaway, J. D. Lancet Infect. Dis. 2016, 16, 935. doi: 10.1016/S1473-3099(16)00146-8
[12]	Cassedy, A.; Parle McDermott, A.; O'Kennedy, R. Front. Mol. Biosci. 2021, 8, 637559. doi: 10.3389/fmolb.2021.637559
[13]	Kim, J. H.; Cho, C. H.; Ryu, M. Y.; Kim, J. G.; Lee, S. J.; Park, T. J.; Park, J. P. PLoS One 2019, 14, e0222144. doi: 10.1371/journal.pone.0222144
[14]	Yang, Y. H.; Song, Z. Y.; Zheng, X. L. J. Pathogen Biol. 2017, 12, 803 ; (in Chinese)
	( 杨永红, 宋璋瑶, 郑学礼, 中国病原生物学杂志, 2017, 12, 803.)
[15]	Jiang, L. Y.; Di, B.; Yang, Z. C. J. Mol. Diagn. Ther. 2018, 3, 196.; (in Chinese)
	( 蒋力云, 狄飚, 杨智聪, 分子诊断与治疗杂志, 2018, 3, 196.)
[16]	Rodriguez, R. A.; Pepper, I. L.; Gerba, C. P. Appl. Environ. Microb. 2009, 75, 297. doi: 10.1128/AEM.01150-08
[17]	Ariffin, E. Y.; Tan, L. L.; Abd Karim, N. H.; Heng, L. Y. Sensors 2018, 18, 1173. doi: 10.3390/s18041173
[18]	Darwish, N. T.; Sekaran, S. D.; Alias, Y.; Khor, S. M. J. Pharmaceut. Biomed. 2018, 149, 591. doi: 10.1016/j.jpba.2017.11.064
[19]	Anusha, J. R.; Kim, B. C.; Yu, K. H.; Raj, C. J. Biosens. Bioelectron. 2019, 142, 111511. doi: 10.1016/j.bios.2019.111511
[20]	Kwakye, S.; Goral, V. N.; Baeumner, A. J. Biosens. Bioelectron. 2006, 21, 2217. doi: 10.1016/j.bios.2005.11.017
[21]	Jain, J.; Okabayashi, T.; Kaur, N.; Nakayama, E.; Shioda, T.; Gaind, R.; Kurosu, T.; Sunil, S. J. Virol. 2018, 15, 84. doi: 10.1186/s12985-018-1000-0
[22]	Teles, F. S. Anal. Chim. Acta 2011, 687, 28. doi: 10.1016/j.aca.2010.12.011
[23]	Guzman, M. G.; Kouri, G. Int. J. Infect. Dis. 2004, 8, 69. doi: 10.1016/j.ijid.2003.03.003
[24]	Raafat, N.; Loganathan, S.; Mukaka, M.; Blacksell, S. D.; Maude, R. J. PLoS Negl. Trop. Dis. 2021, 15, e0009359. doi: 10.1371/journal.pntd.0009359
[25]	Wang, J.; Ma, P.; Kim, D. H.; Liu, B. F.; Demirci, U. Nano Today 2021, 37, 101066. doi: 10.1016/j.nantod.2020.101066
[26]	Sekaran, S. D.; Soe, H. J. Expert Rev. Mol. Diagn. 2017, 17, 217. doi: 10.1080/14737159.2017.1275963
[27]	Pashazadeh, P.; Mokhtarzadeh, A.; Hasanzadeh, M.; Hejazi, M.; Hashemi, M.; De La Guardia, M. Biosens. Bioelectron. 2017, 87, 1050. doi: 10.1016/j.bios.2016.08.012
[28]	Asokanathan, C.; Tierney, S.; Ball, C. R.; Buckle, G.; Day, A.; Tanley, S.; Bristow, A.; Markey, K.; Xing, D.; Yuen, C. T. Anal. Biochem. 2018, 540, 15.
[29]	Alamdari, D. H.; Kostidou, E.; Paletas, K.; Sarigianni, M.; Konstas, A. G.; Karapiperidou, A.; Koliakos, G. Free Radical Bio. Med. 2005, 39, 1362. doi: 10.1016/j.freeradbiomed.2005.06.023
[30]	Kim, A.; Li, C. R.; Jin, C. F.; Lee, K. W.; Lee, S. H.; Shon, K. J.; Park, N. G.; Kim, D. K.; Kang, S. W.; Shim, Y. B.; Park, J. S. Chemosphere 2007, 68, 1204. doi: 10.1016/j.chemosphere.2007.01.079
[31]	Thiha, A.; Ibrahim, F. Sensors 2015, 15, 11431. doi: 10.3390/s150511431
[32]	Hosseini, S.; Ibrahim, F.; Djordjevic, I.; Rothan, H. A.; Yusof, R.; Van Der Marel, C.; Benzina, A.; Koole, L. H. Eur. Polym. J. 2014, 60, 14. doi: 10.1016/j.eurpolymj.2014.08.010
[33]	Hosseini, S.; Azari, P.; Farahmand, E.; Gan, S. N.; Rothan, H. A.; Yusof, R.; Koole, L. H.; Djordjevic, I.; Ibrahim, F. Biosens. Bioelectron. 2015, 69, 257. doi: 10.1016/j.bios.2015.02.034
[34]	Farahmand, E.; Ibrahim, F.; Hosseini, S.; Rothan, H. A.; Yusof, R.; Koole, L. H.; Djordjevic, I. Appl. Surf. Sci. 2015, 353, 1310. doi: 10.1016/j.apsusc.2015.07.004
[35]	Hosseini, S.; Azari, P.; Aeinehvand, M. M.; Rothan, H. A.; Djordjevic, I.; Martinez Chapa, S. O.; Madou, M. J. Appl. Sci. 2016, 6, 336. doi: 10.3390/app6110336
[36]	Ortega, G. A.; Pérez-Rodríguez, S.; Reguera, E. RSC Adv. 2017, 7, 4921. doi: 10.1039/C6RA25992H
[37]	Bang, J.; Park, H.; Choi, W. I.; Sung, D.; Lee, J. H.; Lee, K. Y.; Kim, S. New J. Chem. 2018, 42, 12607. doi: 10.1039/C8NJ02244E
[38]	Chong, Z. L.; Sekaran, S. D.; Soe, H. J.; Peramalah, D.; Rampal, S.; Ng, C. W. BMC Infect. Dis. 2020, 20, 210. doi: 10.1186/s12879-020-4911-5
[39]	Mairiang, D.; Songjaeng, A.; Hansuealueang, P.; Malila, Y.; Lertsethtakarn, P.; Palomares Reyes, C.; Silva Caso, W.; Del Valle, L. J.; Aguilar Luis, M. A.; Weilg, C.; Martins-Luna, J.; Vinas Ospino, A.; Stimmler, L.; Mallqui Espinoza, N.; Aquino Ortega, R.; Espinoza Espiritu, W.; Misaico, E.; Del Valle Mendoza, J. Int. J. Infect. Dis. 2019, 81, 31. doi: 10.1016/j.ijid.2019.01.022
[40]	Palomares Reyes, C.; Silva Caso, W.; Del Valle, L. J.; Aguilar Luis, M. A.; Weilg, C.; Martins Luna, J.; Vinas Ospino, A.; Stimmler, L.; Mallqui Espinoza, N.; Aquino Ortega, R.; Espinoza Espiritu, W.; Misaico, E.; Del Valle-Mendoza, J. Int. J. Infect. Dis. 2019, 81, 31. doi: 10.1016/j.ijid.2019.01.022
[41]	Xu, Y.; Wang, T.; Chen, Z.; Jin, L.; Wu, Z.; Yan, J.; Zhao, X.; Cai, L.; Deng, Y.; Li, S.; He, N. Chin. Chem. Lett. 2021, 17, 9.
[42]	Xiong, Y.; Luo, Y.; Li, H.; Wu, W.; Ruan, X.; Mu, X. Int. J. Infect. Dis. 2020, 95, 406. doi: 10.1016/j.ijid.2020.03.075
[43]	Singh, R. K.; Dhama, K.; Karthik, K.; Tiwari, R.; Khandia, R.; Munjal, A.; Iqbal, H. M. N.; Malik, Y. S.; Bueno Mari, R. Front. Microbiol. 2017, 8, 2677. doi: 10.3389/fmicb.2017.02677
[44]	Sasmono, R. T.; Santoso, M. S.; Pamai, Y. W. B.; Yohan, B.; Afida, A. M.; Denis, D.; Hutagalung, I. A.; Johar, E.; Hayati, R. F.; Yudhaputri, F. A.; Haryanto, S.; Stubbs, S. C. B.; Blacklaws, B. A.; Myint, K. S. A.; Frost, S. D. W. Front. Med. 2020, 7, 582235. doi: 10.3389/fmed.2020.582235
[45]	Walper, S. A.; Lasarte Aragones, G.; Sapsford, K. E.; Brown, C. W.,3rd; Rowland, C. E.; Breger, J. C.; Medintz, I. L.; ACS Sensors 2018, 3, 1894. doi: 10.1021/acssensors.8b00420
[46]	Goud, K. Y.; Reddy, K. K.; Khorshed, A.; Kumar, V. S.; Mishra, R. K.; Oraby, M.; Ibrahim, A. H.; Kim, H.; Gobi, K. V. Biosens. Bioelectron. 2021, 180, 113112. doi: 10.1016/j.bios.2021.113112
[47]	Sasmono, R. T.; Aryati, A.; Wardhani, P.; Yohan, B.; Trimarsanto, H.; Fahri, S.; Setianingsih, T. Y.; Meutiawati, F. PLoS One 2014, 9, e103815. doi: 10.1371/journal.pone.0103815
[48]	Lopez-Jimena, B.; Bekaert, M.; Bakheit, M.; Frischmann, S.; Patel, P.; Simon Loriere, E.; Lambrechts, L.; Duong, V.; Dussart, P.; Harold, G.; Fall, C.; Faye, O.; Sall, A. A.; Weidmann, M. PLoS Negl. Trop. Dis. 2018, 12, e0006381. doi: 10.1371/journal.pntd.0006381
[49]	Teoh, B. T.; Sam, S. S.; Tan, K. K.; Danlami, M. B.; Shu, M. H.; Johari, J.; Hooi, P. S.; Brooks, D.; Piepenburg, O.; Nentwich, O.; Wilder Smith, A.; Franco, L.; Tenorio, A.; Abubakar, S. J. Clin. Microbiol. 2015, 53, 830. doi: 10.1128/JCM.02648-14
[50]	Xi, Y.; Xu, C. Z.; Xie, Z. Z.; Zhu, D. L.; Dong, J. M. Mol. Cell. Probe. 2019, 46, 101413. doi: 10.1016/j.mcp.2019.06.003
[51]	Darwish, N. T.; Alrawi, A. H.; Sekaran, S. D.; Alias, Y.; Khor, S. M. J. Electrochem. Soc. 2016, 163, B19. doi: 10.1149/2.0471603jes
[52]	Gao, M.; Waggoner, J. J.; Hecht, S. M.; Chen, S. ACS Infect. Dis. 2019, 5, 1907. doi: 10.1021/acsinfecdis.9b00241
[53]	Romano, S.; Lamberti, A.; Masullo, M.; Penzo, E.; Cabrini, S.; Rendina, I.; Mocella, V. Materials 2018, 11, 526. doi: 10.3390/ma11040526
[54]	Kravtsov, V.; Khestanova, E.; Benimetskiy, F. A.; Ivanova, T.; Samusev, A. K.; Sinev, I. S.; Pidgayko, D.; Mozharov, A. M.; Mukhin, I. S.; Lozhkin, M. S.; Kapitonov, Y. V.; Brichkin, A. S.; Kulakovskii, V. D.; Shelykh, I. A.; Tartakovskii, A. I.; Walker, P. M.; Skolnick, M. S.; Krizhanovskii, D. N.; Iorsh, I. V. Light Sci. Appl. 2020, 9, 56. doi: 10.1038/s41377-020-0286-z
[55]	Eivazzadeh Keihan, R.; Pashazadeh Panahi, P.; Baradaran, B.; De La Guardia, M.; Hejazi, M.; Sohrabi, H.; Mokhtarzadeh, A.; Maleki, A. Trend. Anal. Chem. 2018, 103, 184. doi: 10.1016/j.trac.2018.03.019
[56]	Hao, N.; Pei, Z.; Liu, P.; Bachman, H.; Naquin, T. D.; Zhang, P.; Zhang, J.; Shen, L.; Yang, S.; Yang, K.; Zhao, S.; Huang, T. J. Small Methods 2020, 16, e2005179.
[57]	Zhou, H.; Liu, J.; Xu, J. J.; Zhang, S. S.; Chen, H. Y. Chem. Soc. Rev. 2018, 47, 1996. doi: 10.1039/C7CS00573C
[58]	Mustapha Kamil, Y.; Abu Bakar, M. H.; Mustapa, M. A.; Yaacob, M. H.; Abidin, N. H. Z.; Syahir, A.; Lee, H. J.; Mahdi, M. A. Sens. Actuators B Chem. 2018, 257, 820. doi: 10.1016/j.snb.2017.11.005
[59]	Vinayagam, S.; Rajaiah, P.; Mukherjee, A.; Natarajan, C. Spectrochim. Acta A 2018, 202, 346. doi: 10.1016/j.saa.2018.05.047
[60]	Adegoke, O.; Park, E. Y. J. Mater. Chem. B 2017, 5, 3047. doi: 10.1039/C7TB00388A
[61]	Mazlan, N. F.; Tan, L. L.; Karim, N. H. A.; Heng, L. Y.; Reza, M. I. H. Sens. Actuators B Chem. 2017, 242, 176. doi: 10.1016/j.snb.2016.11.032
[62]	Loureiro, F. C. C. L.; Neff, H.; Melcher, E. U. K.; Roque, R. A.; De Figueiredo, R. M. P.; Thirstrup, C.; Borre, M. B.; Lima, A. M. N. Sens. Bio-Sens. Res. 2017, 13, 96.
[63]	Wong, W. R.; Sekaran, S. D.; Mahamd Adikan, F. R.; Berini, P. Biosens. Bioelectron. 2016, 78, 132. doi: 10.1016/j.bios.2015.11.030
[64]	Omar, N. A. S.; Fen, Y. W.; Abdullah, J.; Sadrolhosseini, A. R.; Mustapha Kamil, Y.; Fauzi, N. M.; Hashim, H. S.; Mahdi, M. A. Nanomaterials 2020, 10, 569. doi: 10.3390/nano10030569
[65]	Jeningsih; Tan, L. L.; Ulianas, A.; Heng, L. Y.; Mazlan, N. F.; Jamaluddin, N. D.; Mohd Yusof, N. Y.; Khalid, B.; Ta, G. C.. Sensors 2020, 20, 1820. doi: 10.3390/s20071820
[66]	Tian, B.; Fock, J.; Minero, G. A. S.; Hansen, M. F. Biosens. Bioelectron. 2020, 160, 112219. doi: 10.1016/j.bios.2020.112219
[67]	Gahlaut, S. K.; Savargaonkar, D.; Sharan, C.; Yadav, S.; Mishra, P.; Singh, J. P. Anal. Chem. 2020, 92, 2527. doi: 10.1021/acs.analchem.9b04129
[68]	Sanchez-Purra, M.; Carre-Camps, M.; De Puig, H.; Bosch, I.; Gehrke, L.; Hamad-Schifferli, K. ACS Infect. Dis. 2017, 3, 767. doi: 10.1021/acsinfecdis.7b00110
[69]	Song, C.; Zhang, J.; Liu, Y.; Guo, X.; Guo, Y.; Jiang, X.; Wang, L. Sens. Actuators B Chem. 2020, 325, 128970. doi: 10.1016/j.snb.2020.128970
[70]	Omar, N. A. S.; Fen, Y. W.; Ramli, I.; Sadrolhosseini, A. R.; Abdullah, J.; Yusof, N. A.; Kamil, Y. M.; Mahdi, M. A. Polymers 2021, 13, 762. doi: 10.3390/polym13050762
[71]	Santos, A.; Bueno, P. R.; Davis, J. J. Biosens. Bioelectron. 2018, 100, 519. doi: 10.1016/j.bios.2017.09.014
[72]	Brazaca, L. C.; Dos Santos, P. L.; De Oliveira, P. R.; Rocha, D. P.; Stefano, J. S.; Kalinke, C.; Abarza Munoz, R. A.; Bonacin, J. A.; Janegitz, B. C.; Carrilho, E. Anal. Chim. Acta 2021, 1159, 338384. doi: 10.1016/j.aca.2021.338384
[73]	Huang, M. C. Y.; Mateus, C. F. R.; Foley, J. E.; Beatty, R.; Cunningham, B. T.; Chang-Hasnain, C. J. IEEE Photon. Technol. Lett. 2008, 20, 443. doi: 10.1109/LPT.2008.916947
[74]	Carrillo, C.; Werbajh, S.; Malnero, C.; Stolowicz, F.; Larocca, L.; Malirat, V.; Vojnov, A. Int. J. Infect. Dis. 2018, 73, 171.
[75]	Rahman, S. A.; Saadun, R.; Azmi, N. E.; Ariffin, N.; Abdullah, J.; Yusof, N. A.; Sidek, H.; Hajian, R. J. Nanomater. 2014, 2014, 839286.
[76]	Ferraz, F. O.; Quaresma Bomfim, M. R.; Totola, A. H.; Avila, T. V.; Cisalpino, D.; Marques Pessanha, J. E.; De Souza, D. d. G.; Teixeira Junior, A. L.; Nogueira, M. L.; Bruna Romero, O.; Teixeira, M. M. J. Clin. Virol. 2013, 58, 41. doi: 10.1016/j.jcv.2013.06.015
[77]	Pal, S.; Dauner, A. L.; Mitra, I.; Forshey, B. M.; Garcia, P.; Morrison, A. C.; Halsey, E. S.; Kochel, T. J.; Wu, S. J. PLoS One 2014, 9, e113411. doi: 10.1371/journal.pone.0113411
[78]	Sanchez Vargas, L. A.; Sanchez Marce, E. E.; Vivanco Cid, H. Diagn. Micr. Infect. Dis. 2014, 78, 368.
[79]	Fu, C.; Gu, Y.; Wu, Z.; Wang, Y.; Xu, S.; Xu, W. Sens. Actuators B Chem. 2014, 201, 173. doi: 10.1016/j.snb.2014.04.091
[80]	Dinish, U. S.; Balasundaram, G.; Chang, Y. T.; Olivo, M. Sci. Rep. 2015, 4, 4075. doi: 10.1038/srep04075
[81]	Xia, X.; Li, W.; Zhang, Y.; Xia, Y. Interface Focus 2013, 3, 20120092. doi: 10.1098/rsfs.2012.0092
[82]	Ngo, H. T.; Wang, H. N.; Fales, A. M.; Nicholson, B. P.; Woods, C. W.; Vo-Dinh, T. Analyst 2014, 139, 5655. doi: 10.1039/C4AN01077A
[83]	Mohammadzadeh Asl, S.; Keshtkar, A.; Ezzati Nazhad Dolatabadi, J.; De La Guardia, M. Biosens. Bioelectron. 2018, 110, 118. doi: 10.1016/j.bios.2018.03.051
[84]	Hage, D. S. Clin. Chem. 2018, 64, 991. doi: 10.1373/clinchem.2017.282699
[85]	Hu, D.; Fry, S. R.; Huang, J. X.; Ding, X.; Qiu, L.; Pan, Y.; Chen, Y.; Jin, J.; McElnea, C.; Buechler, J.; Che, X.; Cooper, M. A. Biosensors 2013, 3, 297.
[86]	Jahanshahi, P.; Sekaran, S. D.; Adikan, F. R. M. Med. Biol. Eng. Comput. 2015, 53, 679. doi: 10.1007/s11517-015-1262-2
[87]	Oliveira, N.; Souza, E.; Ferreira, D.; Zanforlin, D.; Bezerra, W.; Borba, M. A.; Arruda, M.; Lopes, K.; Nascimento, G.; Martins, D.; Cordeiro, M.; Lima-Filho, J. Sensors 2015, 15, 15562. doi: 10.3390/s150715562
[88]	Chan, S. K.; Choong, Y. S.; Perera, D.; Lim, T. S. Anal. Methods 2018, 10, 214. doi: 10.1039/C7AY02131C
[89]	Shen, W.; Gao, Z. Biosens. Bioelectron. 2015, 65, 327. doi: 10.1016/j.bios.2014.10.060
[90]	Chowdhury, A. D.; Ganganboina, A. B.; Nasrin, F.; Takemura, K.; Doong, R. a.; Utomo, D. I. S.; Lee, J.; Khoris, I. M.; Park, E. Y. Anal. Chem. 2018, 90, 12464. doi: 10.1021/acs.analchem.8b01802
[91]	Hsieh, M. S.; Chen, M. Y.; Hsieh, C. H.; Pan, C. H.; Yu, G. Y.; Chen, H. W. PLoS One 2017, 12, e0188170. doi: 10.1371/journal.pone.0188170
[92]	Xie, B. P.; Qiu, G. H.; Hu, P. P.; Liang, Z.; Liang, Y. M.; Sun, B.; Bai, L. P.; Jiang, Z. H.; Chen, J. X. Sens. Actuators B Chem. 2018, 254, 1133. doi: 10.1016/j.snb.2017.06.085
[93]	He, Z.; Wu, J.; Qiao, B.; Pei, H.; Xia, Q.; Wu, Q.; Ju, H. ACS Appl. Bio Mater. 2020, 3, 5342. doi: 10.1021/acsabm.0c00658
[94]	Dias, A. C. M. S.; Gomes Filho, S. L. R.; Silva, M. M. S.; Dutra, R. F. Biosens. Bioelectron. 2013, 44, 216. doi: 10.1016/j.bios.2012.12.033
[95]	Silva, M. M. S.; Dias, A. C. M. S.; Silva, B. V. M.; Gomes-Filho, S. L. R.; Kubota, L. T.; Goulart, M. O. F.; Dutra, R. F. J. Chem. Technol. Biot. 2015, 90, 194.
[96]	Cavalcanti, I. T.; Guedes, M. I. F.; Sotomayor, M. D. P. T.; Yamanaka, H.; Dutra, R. F. Biochem. Eng. J. 2012, 67, 225. doi: 10.1016/j.bej.2012.06.016
[97]	Cheng, M. S.; Ho, J. S.; Tan, C. H.; Wong, J. P.; Ng, L. C.; Toh, C. S. Anal. Chim. Acta 2012, 725, 74. doi: 10.1016/j.aca.2012.03.017
[98]	Souza, E.; Nascimento, G.; Santana, N.; Ferreira, D.; Lima, M.; Natividade, E.; Martins, D.; Lima-Filho, J. Sensors 2011, 11, 5616. doi: 10.3390/s110605616
[99]	Rai, V.; Hapuarachchi, H. C.; Ng, L. C.; Soh, S. H.; Leo, Y. S.; Toh, C. S. PLoS One 2012, 7, e42346. doi: 10.1371/journal.pone.0042346
[100]	Singhal, C.; Pundir, C. S.; Narang, J. Biosens. Bioelectron. 2017, 97, 75. doi: 10.1016/j.bios.2017.05.047
[101]	Tripathy, S.; Krishna Vanjari, S. R.; Singh, V.; Swaminathan, S.; Singh, S. G. Biosens. Bioelectron. 2017, 90, 378. doi: 10.1016/j.bios.2016.12.008
[102]	Silva, M. M.; Dias, A. C.; Cordeiro, M. T.; Marques, E.,Jr.; Goulart, M. O.; Dutra, R. F.; Talanta 2014, 128, 505. doi: 10.1016/j.talanta.2014.06.009
[103]	Figueiredo, A.; Vieira, N. C.; Dos Santos, J. F.; Janegitz, B. C.; Aoki, S. M.; Junior, P. P.; Lovato, R. L.; Nogueira, M. L.; Zucolotto, V.; Guimaraes, F. E. Sci. Rep. 2015, 5, 7865. doi: 10.1038/srep07865
[104]	Cecchetto, J.; Carvalho, F. C.; Santos, A.; Fernandes, F. C. B.; Bueno, P. R. Sens. Actuators B Chem. 2015, 213, 150. doi: 10.1016/j.snb.2015.02.068
[105]	Luna, D. M.; Oliveira, M. D.; Nogueira, M. L.; Andrade, C. A. Chem. Phys. Lipids 2014, 180, 7. doi: 10.1016/j.chemphyslip.2014.02.008
[106]	Oliveira, M. D.; Correia, M. T.; Diniz, F. B. Biosens. Bioelectron. 2009, 25, 728. doi: 10.1016/j.bios.2009.08.009
[107]	Oliveira, M. D. L.; Nogueira, M. L.; Correia, M. T. S.; Coelho, L. C. B. B.; Andrade, C. A. S. Sens. Actuators B Chem. 2011, 155, 789. doi: 10.1016/j.snb.2011.01.049
[108]	Avelino, K. Y. P. S.; Andrade, C. A. S.; De Melo, C. P.; Nogueira, M. L.; Correia, M. T. S.; Coelho, L. C. B. B.; Oliveira, M. D. L. Synthetic Met. 2014, 194, 102. doi: 10.1016/j.synthmet.2014.05.001
[109]	Andrade, C. A.; Oliveira, M. D.; De Melo, C. P.; Coelho, L. C.; Correia, M. T.; Nogueira, M. L.; Singh, P. R.; Zeng, X. J. Colloid Interf. Sci. 2011, 362, 517. doi: 10.1016/j.jcis.2011.07.013
[110]	Palomar, Q.; Gondran, C.; Marks, R.; Cosnier, S.; Holzinger, M. Electrochim. Acta 2018, 274, 84. doi: 10.1016/j.electacta.2018.04.099
[111]	Luna, D. M. N.; Avelino, K. Y. P. S.; Cordeiro, M. T.; Andrade, C. A. S.; Oliveira, M. D. L. Sens. Actuators B Chem. 2015, 220, 565. doi: 10.1016/j.snb.2015.05.067
[112]	Navakul, K.; Warakulwit, C.; Yenchitsomanus, P. T.; Panya, A.; Lieberzeit, P. A.; Sangma, C. Nanomedicine 2017, 13, 549.
[113]	Deng, J.; Toh, C. S. Sensors 2013, 13, 7774. doi: 10.3390/s130607774
[114]	Jin, S. A.; Poudyal, S.; Marinero, E. E.; Kuhn, R. J.; Stanciu, L. A. Electrochim. Acta 2016, 194, 422. doi: 10.1016/j.electacta.2016.02.116
[115]	Goode, J. A.; Rushworth, J. V.; Millner, P. A. Langmuir 2015, 31, 6267. doi: 10.1021/la503533g
[116]	Janegitz, B. C.; Silva, T. A.; Wong, A.; Ribovski, L.; Vicentini, F. C.; Taboada Sotomayor, M. D. P.; Fatibello Filho, O. Biosens. Bioelectron. 2017, 89, 224. doi: 10.1016/j.bios.2016.03.026
[117]	Oztekin, Y.; Ramanaviciene, A.; Yazicigil, Z.; Solak, A. O.; Ramanavicius, A. Biosens. Bioelectron. 2011, 26, 2541. doi: 10.1016/j.bios.2010.11.001
[118]	Sinawang, P. D.; Rai, V.; Ionescu, R. E.; Marks, R. S. Biosens. Bioelectron. 2016, 77, 400. doi: 10.1016/j.bios.2015.09.048
[119]	Nuzaihan, M. N. M.; Hashim, U.; Md Arshad, M. K.; Kasjoo, S. R.; Rahman, S. F.; Ruslinda, A. R.; Fathil, M. F.; Adzhri, R.; Shahimin, M. M. Biosens. Bioelectron. 2016, 83, 106. doi: 10.1016/j.bios.2016.04.033
[120]	Anusha, J. R.; Fleming, A. T.; Kim, H. J.; Kim, B. C.; Yu, K. H.; Raj, C. J. Bioelectrochemistry 2015, 104, 44. doi: 10.1016/j.bioelechem.2015.02.004
[121]	Krikstolaityte, V.; Kuliesius, J.; Ramanaviciene, A.; Mikoliunaite, L.; Kausaite Minkstimiene, A.; Oztekin, Y.; Ramanavicius, A. Polymer 2014, 55, 1613. doi: 10.1016/j.polymer.2014.02.003
[122]	Bazin, I.; Tria, S. A.; Hayat, A.; Marty, J. L. Biosens. Bioelectron. 2017, 87, 285. doi: 10.1016/j.bios.2016.06.083
[123]	Zhang, S.; Geryak, R.; Geldmeier, J.; Kim, S.; Tsukruk, V. V. Chem. Rev. 2017, 117, 12942. doi: 10.1021/acs.chemrev.7b00088
[124]	Basso, C. R.; Tozato, C. C.; Crulhas, B. P.; Castro, G. R.; Junior, J. P. A.; Pedrosa, V. A. J. Virol. 2018, 513, 85.
[125]	Hasanzadeh, M.; Karimzadeh, A.; Sadeghi, S.; Mokhtarzadeh, A.; Shadjou, N.; Jouyban, A. J. Mater. Sci. Mater. Electron. 2016, 27, 6488. doi: 10.1007/s10854-016-4590-6
[126]	Vermisoglou, E.; Panacek, D.; Jayaramulu, K.; Pykal, M.; Frebort, I.; Kolar, M.; Hajduch, M.; Zboril, R.; Otyepka, M. Biosens. Bioelectron. 2020, 166, 112436. doi: 10.1016/j.bios.2020.112436
[127]	Zhang, W.; Xiao, G.; Chen, J.; Wang, L.; Hu, Q.; Wu, J.; Zhang, W.; Song, M.; Qiao, J.; Xu, C. Anal. Bioanal. Chem. 2021, 413, 2407. doi: 10.1007/s00216-021-03197-8
[128]	Choi, Y.; Hwang, J. H.; Lee, S. Y. Small Methods 2018, 2, 1700351. doi: 10.1002/smtd.v2.4
[129]	Rashid, J. I.; Yusof, N. A.; Abdullah, J.; Hashim, U.; Hajian, R. Mater. Sci. Eng. C Mater. Biol. Appl. 2014, 45, 270. doi: 10.1016/j.msec.2014.09.010
[130]	Zhang, L.; Gu, C.; Wen, J.; Liu, G.; Liu, H.; Li, L. Anal. Bioanal. Chem. 2021, 413, 83. doi: 10.1007/s00216-020-03000-0
[131]	Fu, J.; Wu, J.; Zhang, R.; Wu, Q.; Ju, H. Sens. Actuators B Chem. 2021, 345, 130436. doi: 10.1016/j.snb.2021.130436
[132]	Sinawang, P. D.; Fajs, L.; Elouarzaki, K.; Nugraha, J.; Marks, R. S. Sens. Actuators B Chem. 2018, 259, 354. doi: 10.1016/j.snb.2017.12.043
[133]	Lim, J. M.; Kim, J. H.; Ryu, M. Y.; Cho, C. H.; Park, T. J.; Park, J. P. Anal. Chim. Acta 2018, 1026, 109. doi: 10.1016/j.aca.2018.04.005
[134]	Palomar, Q.; Xu, X.; Gondran, C.; Holzinger, M.; Cosnier, S.; Zhang, Z. Mikrochim. Acta 2020, 187, 363. doi: 10.1007/s00604-020-04339-y
[135]	Cecchetto, J.; Santos, A.; Mondini, A.; Cilli, E. M.; Bueno, P. R. Biosens. Bioelectron. 2020, 151, 111972. doi: 10.1016/j.bios.2019.111972
[136]	Khristunova, E.; Dorozhko, E.; Korotkova, E.; Kratochvil, B.; Vyskocil, V.; Barek, J. Sensors 2020, 20, 4600. doi: 10.3390/s20164600
[137]	Nascimento, H. P.; Oliveira, M. D.; De Melo, C. P.; Silva, G. J.; Cordeiro, M. T.; Andrade, C. A. Colloids Surf. B 2011, 86, 414. doi: 10.1016/j.colsurfb.2011.04.028
[138]	Solanki, S.; Soni, A.; Pandey, M. K.; Biradar, A.; Sumana, G. ACS Appl. Mater. Inter. 2018, 10, 3020. doi: 10.1021/acsami.7b14391
[139]	Wasik, D.; Mulchandani, A.; Yates, M. V. Sensors 2018, 18, 2641. doi: 10.3390/s18082641
[140]	Senapati, S.; Slouka, Z.; Shah, S. S.; Behura, S. K.; Shi, Z.; Stack, M. S.; Severson, D. W.; Chang, H. C. Biosens. Bioelectron. 2014, 60, 92. doi: 10.1016/j.bios.2014.04.008

Detection method	Type of Dengue	Nano materials	Limit of detection	Linear range	Reference
Optical DNA biosensor	Dengue serotype 2	Silica nanospheres	0.2 amol/L	1.0×10^-16~1.0×10^-10 mol/L	^[17]
SERS based lateral flow biosensor	NS1 protein	—	15 ng/mL	15~500 ng/mL	^[18]
Label-free biosensor	Dengue serotype 2	—	1 pmol/L	—	^[58]
Colorimetric biosensor	Different Dengue serotypes	Silver nanoparticles	—	—	^[59]
SPR biosensor	—	AuNPs	—	31~260 copies/mL	^[60]
Optical DNA biosensor	Dengue serotype 2	Silica nanoparticles	1 zmol/L	1.0×10^-15~1.0×10^-11mol/L	^[61]
SRP biosensor	Dengue serotype 2 and 3	—	2×10⁴ particles/mL	—	^[62]
LSPR fiber optic sensor	Dengue anti-NS1 antibody	Gold nanoparticles	1.54 nmol/L	—	^[7]
LSPR biosensor	Dengue anti-NS1 antibody	—	5.73 pg/mm²	—	^[63]
SRP biosensor	Dengue serotype 2	rGO-PAMAM	—	0.08~0.5 pmol/L	^[64]
Optical DNA biosensor	Dengue DNA sequence	AuNPs	1×10^-29 mol/L	1.0×10^-21~1.0×10^-12 mol/L	^[65]
Optical DNA biosensor	Dengue DNA sequence	—	2 fmol/L	≈1 pmol/L	^[66]
SERS biosensor	NS1 protein	Silver nanorods	—	—	^[67]
SERS biosensor	NS1 protein	AuNPs	7.67 ng/mL	—	^[68]
SERS biosensor	Dengue DNA sequence	—	0.49 fmol/L	1 fmol/L~10 nmol/L	^[69]
SRP biosensor	Dengue serotype 2	—	0.08 pmol/L	0.08~5 pmol/L	^[70]

Detection method	Type of Dengue	Nano materials	Limit of detection	Linear range	Reference
Optical DNA biosensor	Dengue serotype 2	Silica nanospheres	0.2 amol/L	1.0×10^-16~1.0×10^-10 mol/L	^[17]
SERS based lateral flow biosensor	NS1 protein	—	15 ng/mL	15~500 ng/mL	^[18]
Label-free biosensor	Dengue serotype 2	—	1 pmol/L	—	^[58]
Colorimetric biosensor	Different Dengue serotypes	Silver nanoparticles	—	—	^[59]
SPR biosensor	—	AuNPs	—	31~260 copies/mL	^[60]
Optical DNA biosensor	Dengue serotype 2	Silica nanoparticles	1 zmol/L	1.0×10^-15~1.0×10^-11mol/L	^[61]
SRP biosensor	Dengue serotype 2 and 3	—	2×10⁴ particles/mL	—	^[62]
LSPR fiber optic sensor	Dengue anti-NS1 antibody	Gold nanoparticles	1.54 nmol/L	—	^[7]
LSPR biosensor	Dengue anti-NS1 antibody	—	5.73 pg/mm²	—	^[63]
SRP biosensor	Dengue serotype 2	rGO-PAMAM	—	0.08~0.5 pmol/L	^[64]
Optical DNA biosensor	Dengue DNA sequence	AuNPs	1×10^-29 mol/L	1.0×10^-21~1.0×10^-12 mol/L	^[65]
Optical DNA biosensor	Dengue DNA sequence	—	2 fmol/L	≈1 pmol/L	^[66]
SERS biosensor	NS1 protein	Silver nanorods	—	—	^[67]
SERS biosensor	NS1 protein	AuNPs	7.67 ng/mL	—	^[68]
SERS biosensor	Dengue DNA sequence	—	0.49 fmol/L	1 fmol/L~10 nmol/L	^[69]
SRP biosensor	Dengue serotype 2	—	0.08 pmol/L	0.08~5 pmol/L	^[70]

Electrode	Detection technique	Analyte	Linear range	Limit of detection	Reference
CNT-SPE	CA	NS1	0.04~2 μg/mL	12 ng/mL	^[94]
PAH/CNT	CV	NS1	0.1~2.5 μg/mL	0.035 μg/mL	^[95]
Au/CD	DPV	NS1	1~100 ng/mL	0.33 ng /mL	^[96]
Nanoporous alumina/Pt wire	DPV	DENV-2	1~10³ pfu/mL	1 pfu/mL	^[97]
PGE	DPV	DENV-1	1~40 nmol/L	0.92 nmol/L	^[98]
Nanoporous alumina/Pt wire	DPV	DENV1(31-mer ssDNA)	10^-12~10^-6mol/L	9.55×10^-12mol/L	^[99]
ZnO/Pt-Pd	CV/DPV	DENV target ssDNA	1×10^-6~100×10^-6mol/L	4.3×10^-6mol/L	^[100]
Mn₂O₃nanofiber	CV/DPV/EIS	Dengue consensus primer	1 nmol/L~1 μmol/L	120×10^-21mol/L	^[101]
Thiophene-SPE/AuNPs /Protein A	CV/EIS	NS1	0.04~0.6 μg/mL	0.015 μg/mL	^[102]
PGE	DPV	DENV-3	10~100 nmol/L	3.09 nmol/L	^[87]
Au	EIS/CV	NS1	0.1~10 μg/mL	0.09 μg/mL	^[103]
Au	EIS/CV	NS1	0.01~1.00 μg/mL	30 ng/mL	^[104]
Au/liposome	EIS/CV	DENV-1~DENV-3	0.01~1.00 μg/mL	3 ng/mL	^[105]
AuNPs/PVB	EIS/CV	Dengue fever and Dengue haemorrhagic	—	—	^[106]
Fe₃O₄/PVB	EIS/CV	DENV-1~DENV-3	—	—	^[107]
AuNPs/PANI/CramoLL	EIS/CV	Glycoproteins from DENV-1~DENV-3	—	—	^[108]
AuNPs/PANI/BMOLL	EIS/CV	Glycoproteins from DENV-1~DENV-3	—	—	^[109]
CNT/polypyrrole-NHS	EIS/CV	DENV-2	10^-13~10^-5g/mL	—	^[110]
Cys-MBA-AuNPs	EIS/CV	DENV-1~DENV-4	—	—	^[111]
GO-PMC	EIS/CV	DENV-1~DENV-4	1~2×10³pfu/mL	0.12 pfu/mL	^[112]
AAO	EIS/CV	DENV DNA	1×10^-12~1×10^-6mol/L	2.7×10^-12mol/L	^[113]
SiO₂/APTES-GO	EIS	DENV DNA	—	1 fmol/L	^[114]

Electrode	Detection technique	Analyte	Linear range	Limit of detection	Reference
CNT-SPE	CA	NS1	0.04~2 μg/mL	12 ng/mL	^[94]
PAH/CNT	CV	NS1	0.1~2.5 μg/mL	0.035 μg/mL	^[95]
Au/CD	DPV	NS1	1~100 ng/mL	0.33 ng /mL	^[96]
Nanoporous alumina/Pt wire	DPV	DENV-2	1~10³ pfu/mL	1 pfu/mL	^[97]
PGE	DPV	DENV-1	1~40 nmol/L	0.92 nmol/L	^[98]
Nanoporous alumina/Pt wire	DPV	DENV1(31-mer ssDNA)	10^-12~10^-6mol/L	9.55×10^-12mol/L	^[99]
ZnO/Pt-Pd	CV/DPV	DENV target ssDNA	1×10^-6~100×10^-6mol/L	4.3×10^-6mol/L	^[100]
Mn₂O₃nanofiber	CV/DPV/EIS	Dengue consensus primer	1 nmol/L~1 μmol/L	120×10^-21mol/L	^[101]
Thiophene-SPE/AuNPs /Protein A	CV/EIS	NS1	0.04~0.6 μg/mL	0.015 μg/mL	^[102]
PGE	DPV	DENV-3	10~100 nmol/L	3.09 nmol/L	^[87]
Au	EIS/CV	NS1	0.1~10 μg/mL	0.09 μg/mL	^[103]
Au	EIS/CV	NS1	0.01~1.00 μg/mL	30 ng/mL	^[104]
Au/liposome	EIS/CV	DENV-1~DENV-3	0.01~1.00 μg/mL	3 ng/mL	^[105]
AuNPs/PVB	EIS/CV	Dengue fever and Dengue haemorrhagic	—	—	^[106]
Fe₃O₄/PVB	EIS/CV	DENV-1~DENV-3	—	—	^[107]
AuNPs/PANI/CramoLL	EIS/CV	Glycoproteins from DENV-1~DENV-3	—	—	^[108]
AuNPs/PANI/BMOLL	EIS/CV	Glycoproteins from DENV-1~DENV-3	—	—	^[109]
CNT/polypyrrole-NHS	EIS/CV	DENV-2	10^-13~10^-5g/mL	—	^[110]
Cys-MBA-AuNPs	EIS/CV	DENV-1~DENV-4	—	—	^[111]
GO-PMC	EIS/CV	DENV-1~DENV-4	1~2×10³pfu/mL	0.12 pfu/mL	^[112]
AAO	EIS/CV	DENV DNA	1×10^-12~1×10^-6mol/L	2.7×10^-12mol/L	^[113]
SiO₂/APTES-GO	EIS	DENV DNA	—	1 fmol/L	^[114]

登革热病毒检测的生物传感技术

Biosensing Technology for Dengue Virus Detection

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

Fig. & Tab. 12

References 140

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Lanying Li, Qing Tao, Yanli Wen, Lele Wang, Ruiyan Guo, Gang Liu, Xiaolei Zuo. Poly-adenine-based DNA Probes and Their Applications in Biosensors^★ [J]. Acta Chimica Sinica, 2023, 81(6): 681-690.
[2]	Ziyu Zhu, Axin Liang, Ruilin Haotian, Shanshan Tang, Miao Liu, Bingteng Xie, Aiqin Luo. Application of Biosensors in the Detection of SARS-CoV-2 [J]. Acta Chimica Sinica, 2023, 81(3): 253-263.
[3]	Ruilin Haotian, Ziyu Zhu, Yanhui Cai, Wei Wang, Zhen Wang, Axin Liang, Aiqin Luo. Application of Covalent Organic Framework-Based Electrochemical Biosensors in Biological Sample Detection [J]. Acta Chimica Sinica, 2022, 80(11): 1524-1535.
[4]	Ni Liao, Xia Zhong, Wen-Bin Liang, Ruo Yuan, Ying Zhuo. Metal-organic Frameworks (MOF)-based Novel Electrochemiluminescence Biosensing Platform for Quantification of H₂O₂ Releasing from Tumor Cells [J]. Acta Chimica Sinica, 2021, 79(10): 1257-1264.
[5]	Jin Xin, Wang XiaoYing. Progress in Analysis and Detection of Salivary Tumor Biomarkers Associated with Oral Cancer [J]. Acta Chim. Sinica, 2019, 77(4): 340-350.
[6]	Hu Zhengli, Du Jihui, Ying Yilun, Peng Yueyi, Cao Chan, Long Yi-Tao. Single-Molecule Analysis of Colorectal Cancer-associated MicroRNAs via a Biological Nanopore [J]. Acta Chim. Sinica, 2017, 75(11): 1087-1090.
[7]	Wang Qin, Nie Zhou, Hu Yufang, Yao Shouzhuo. Electrochemical Assay for Acetylcholinesterase Activity Detection Based on Unique Electro-catalytic Activity of Cu(II)-thiol Coordination Polymer [J]. Acta Chim. Sinica, 2017, 75(11): 1109-1114.
[8]	Liu Xingfen, Wang Yateng, Huang Yanqin, Feng Xiaomiao, Fan Quli, Huang Wei. Highly Sensitive Protein Biosensor based on a Conjugated Polymer Brush [J]. Acta Chim. Sinica, 2016, 74(8): 664-668.
[9]	Li Laicai, Zhang Ming, Mao Shuang, Yang Chun, Tian Anmin. Theoretical Investigation on the Adsorption of DNA Bases on B-doped SWCNT Surface [J]. Acta Chimica Sinica, 2015, 73(2): 143-150.
[10]	Zhang Jiajia, Dai Peiqing, Li Chao, Li Nanwang, Cheng Guifang, He Pingang, Fang Yuzhi. A Symmetrically Split G-quadruplex DNAzymes Biosensor Based on Magnetic Nanoparticles for the Rapid Detection of Hg²⁺ [J]. Acta Chimica Sinica, 2014, 72(9): 1029-1035.
[11]	Wu Chao, Yang Shengyuan, Wu Zhaoyang, Shen Guoli, Yu Ruqin. Split Aptamer-Based Liquid Crystal Biosensor for ATP Assay [J]. Acta Chimica Sinica, 2013, 71(03): 367-370.
[12]	Wu Xingyi, Zhang Lei, Lü Dan, Liu Yanhua, Chen Yanan, Su Weijun, Luo Na, Xiang Rong. Application of Surface Plasmon Resonance Sensors in the Early Diagnosis of Cancer [J]. Acta Chimica Sinica, 2013, 71(03): 299-301.
[13]	Yang Shaoming, Zha Wenling, Li Hong, Sun Qing, Zheng Longzhen. Study of Label-free Bi-analyte Detection Aptamer Biosensor [J]. Acta Chimica Sinica, 2013, 71(03): 451-456.
[14]	Xia Qianfang, Luo Dan, Li Zaijun. Electrochemical Fabrication and Application of the Glucose Biosensor Based on Graphene [J]. Acta Chimica Sinica, 2012, 70(19): 2079-2084.
[15]	Wang Qing, Zhu Hongzhi, Yang Xiaohai, Wang Kemin, Yang Lijuan, Ding Jing. High Sensitive Coralyne Detection by Using of Au Nanoparticles-Enhanced Surface Plasmon Resonance Biosensor [J]. Acta Chimica Sinica, 2012, 70(13): 1483-1487.