Acta Chim. Sinica ›› 2018, Vol. 76 ›› Issue (3): 168-176.DOI: 10.6023/A17110499 Previous Articles     Next Articles



赵克丽a,b, 郝莹a, 朱墨a,c, 程国胜a,b   

  1. a 中国科学院纳米-生物界面重点实验室 中国科学院苏州纳米技术与纳米仿生研究所 苏州 215123;
    b 中国科学院大学 北京 100049;
    c 上海大学化学系 上海 200444
  • 投稿日期:2017-11-22 发布日期:2018-01-09
  • 通讯作者: 程国胜
  • 作者简介:赵克丽,2015年毕业于扬州大学,获工学学士学位,在生物医学部纳米-生物界面重点实验室、程国胜课题组从事三维石墨烯的生物降解性的研究;郝莹,2013年获苏州大学高分子化学与物理专业博士学位;朱墨,2016年毕业于东北农业大学,获理学学士学位.主要研究方向为三维石墨烯支架的构建与促进神经干细胞分化研究;程国胜,1999年7月中国科学院固体物理所获得理学博士学位.从事纳米线电子器件制作工艺和纳电子学表征研究.主要从事纳米器件.纳电子学和纳米结构集成技术研究.
  • 基金资助:


A Review: Biodegradation Strategy of Graphene-Based Materials

Zhao Kelia,b, Hao Yinga, Zhu Moa,c, Cheng Guoshenga,b   

  1. a CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Jiangsu 215123;
    b University of Chinese Academy of Sciences, Beijing 100049;
    c University of Shanghai, Shanghai 200444
  • Received:2017-11-22 Published:2018-01-09
  • Contact: 10.6023/A17110499
  • Supported by:

    Project supported by the National Key Basic Research Program of China (973 Program, No. 2014CB965003).

Since its discovery in 2004, the new frontier materials graphene and its derivatives have attracted a great deal of attention on the fields of new batteries, sensors, new energy and biomedicine, due to their unique electrical, optical and mechanical properties. Specifically, it has been developed rapidly in the biomedical field. The good biocompatibility has endowed graphene and its derivatives great prospects for their biological applications. In order to realize the in vivo application of graphene materials and improve the safety of the environment and life system, it is crucial to consider and study on the biodegradation behaviors of graphene. The research on biodegradation of graphene currently mainly focuses on the enzymatic degradation. The degradation behaviors can be tuned by the modification via a series of methods, such as heterogeneous atom doping and surface functionalization, etc. The progress of biodegradation of graphene and their derivatives, especially the enzymatic degradation and their biomedical applications is discussed. The important basis and guidance to further promote the in vivo study of graphene materials will be provided.

Key words: graphene, biocompatibility, enzymatic degradation, surface modification