Acta Chimica Sinica ›› 2002, Vol. 60 ›› Issue (3): 518-523. Previous Articles     Next Articles

Original Articles

距离比较法(DISCO)构建ALS抑制剂药效团模型

陈凯;程永浩;杨华铮   

  1. 南开大学元素有机化学研究所.天津(300071)
  • 发布日期:2002-03-15

Using DISCO Method to Build Pharmacophore Model of ALS Inhibitors

Chen Kai;Cheng Yonghao;Yang Huazheng   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University.Tianjin(300071)
  • Published:2002-03-15

In this paper, ten typical acetolactate synthase (ALS) inhibitors were superimposed to fit with their most favorite conformation to build ALS Inhibitors' 3D-pharmacophore model by using distance- comparisons (DISCO) method without the previous knowledge of the three- dimensional structures of ALS.

Key words: acetolacta synthase, THREE DIMENSIONAL STRUCTURE, INHIBITOR, PESTICIDE EFFECT, CONFORMATION

CLC Number: