Schiff Reaction, Mechanism Analysis and Antibacterial Activity of Condensed Product from 2-(4,4,4-Trifiuoro-3-oxo-butyryl) thiophene with Naphthylamine

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (20): 2045-2050. Previous Articles Next Articles

噻吩甲酰三氟丙酮与萘胺的缩合反应、机理分析和抑菌活性

王瑾玲¹, 丁峰^1,2, 郁铭³, 李培凡⁴

1. 天津师范大学化学与生命科学院, 天津, 300074;
2. 天津理工学院环境与安全工程系, 天津, 300191;
3. 天津科技大学理学院, 天津, 300122;
4. 天津高等医学专科学校药学系, 天津, 300052

投稿日期:2003-09-15 修回日期:2004-04-12 发布日期:2014-02-17
通讯作者: 王瑾玲,E-mail:wangjinling43@sohu.com E-mail:wangjinling43@sohu.com
基金资助:
天津市科委自然科学基金(No.003601711)资助项目.

Schiff Reaction, Mechanism Analysis and Antibacterial Activity of Condensed Product from 2-(4,4,4-Trifiuoro-3-oxo-butyryl) thiophene with Naphthylamine

WANG Jin-Ling¹, DING Feng^1,2, YU Ming³, LI Pei-Fan⁴

1. Institue of Chemical Crystallography, Tianjin Normal University, Tianjin 300074;
2. Department of Environment and Safety Engineering, Tianjin University of Technology, Tianjin 300191;
3. College of Science, University of Tianjin Scientific Technology, Tianjin 300122;
4. Medical Department, Tianjin Medical School, Tianjin 300052

Received:2003-09-15 Revised:2004-04-12 Published:2014-02-17

Abstract

Trifluoro-3-oxo-naphthyliminobutyryl)thiophene (TOBT-NA) condensed from TTA with 1- and 2-naphthylamine and its Cu(Ⅱ), Co(Ⅱ), Ni(Ⅱ) and Zn(Ⅱ) complexes are reported now. The mechanism of the condensed reaction has been discussed using quantum chemistry and molecular mechanic calculation methods, which can explain the enamine conformation of the ligand and the imine-enol conformation of the complexes. Using disc diffusion method, the antibacterial activity tests have been conducted, which provides beneficial consult for studying the relationship between the structures and performances.

Key words: TOBT-NA, condensed reaction, quantum chemical calculation, mechanism analysis, antibacterial activity

Cite this article

WANG Jin-Ling, DING Feng, YU Ming, LI Pei-Fan. Schiff Reaction, Mechanism Analysis and Antibacterial Activity of Condensed Product from 2-(4,4,4-Trifiuoro-3-oxo-butyryl) thiophene with Naphthylamine[J]. Acta Chimica Sinica, 2004, 62(20): 2045-2050.

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噻吩甲酰三氟丙酮与萘胺的缩合反应、机理分析和抑菌活性

Schiff Reaction, Mechanism Analysis and Antibacterial Activity of Condensed Product from 2-(4,4,4-Trifiuoro-3-oxo-butyryl) thiophene with Naphthylamine

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