Studies on the Formation, DNA-Binding and Luminescent Properties of New Heterobimetallic Complexes

Abstract

The binding modes of polypyridyl ruthenium(II) complexes [Ru(phen)₂CImP]^2＋(CImP: 3,4-dihydroxyl-imidazo[4,5-i](1,10-phenanthroline) and [Ru(phen)₂TPPZ]^2＋(TPPZ: tetrapyrido[3,2-c:2', 3'-e:3'',2''-j:2''',3'''-l]phenazine) with calf thymus DNA have been investigated by spectroscopic and viscosity methods. The luminescent properties of coordinated complexes with Zn^2＋ were also studied. The experimental results indicated that [Ru(phen)₂TPPZ]^2＋ bound to DNA by intercalation, while [Ru(phen)₂CImP]^2＋ bound to DNA by groove binding mode. Both complexes could be coordinated with Zn^2＋ to form the heterobimetallic complexes [Ru(phen)₂(TPPZ)Zn]^4＋ and [Ru(phen)₂(CImP)Zn]^4＋, and the emission intensity of complexes decreased with increasing the amount of Zn^2＋. After binding to DNA, both original complexes could be coordinated with Zn^2＋ to form the heterobimetallic complexes, and [Ru(phen)₂(TPPZ)Zn]^4＋ kept binding to DNA by intercalation, with the emission intensity decreased, while the binding mode of [Ru(phen)₂(CImP)Zn]^4＋ was changed from groove binding to intercalation, with increase of the emission intensity.

Key words: polypyridyl ruthenium(II) complex, DNA, zinc(II), luminescence, intercalation

Cite this article

ZHANG Qian-Ling*^,1, LIU Jian-Hong*^,1, REN Xiang-Zhong, ZHANG Pei-Xin^1,3, LI Cui-Hua, WANG Fang, XU Hong, LIU Jian-Zhong², JI Liang-Nian^{2<. Studies on the Formation, DNA-Binding and Luminescent Properties of New Heterobimetallic Complexes[J]. Acta Chimica Sinica, 2006, 64(10): 968-974.}

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新型双核配合物的形成、与DNA的作用机制及荧光性质研究