DNA-binding and Photocleavage Studies on Polypyridyl Ruthe-nium(II) Complexes Containing Steric Hinderance Group

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (15): 1464-1468. Previous Articles Next Articles

Original Articles

带有位阻基团的钌多吡啶配合物与DNA键合及其光断裂DNA性质的研究

蒲小华¹,2, 陈绘丽¹, 韩高义¹, 杨频*^,1

(¹山西大学分子科学研究所化学生物学与分子工程教育部重点实验室太原 030006)
(²宝鸡文理学院化学化工系宝鸡 721007)

投稿日期:2006-05-09 修回日期:2007-01-19 发布日期:2007-08-14
通讯作者: 杨频

DNA-binding and Photocleavage Studies on Polypyridyl Ruthe-nium(II) Complexes Containing Steric Hinderance Group

PU Xiao-Hua¹,2; CHEN Hui-Li¹; HAN Gao-Yi¹; YANG Pin*^,1

(¹ Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan 030006)
(² Department of Chemistry, Baoji University of Arts and Science, Baoji 721007)

Received:2006-05-09 Revised:2007-01-19 Published:2007-08-14
Contact: YANG Pin

Abstract

The polypyridyl ruthenium(II) complexes of [Ru(bpy)₂DMNP]^2＋ and [Ru(bpy)₂BOPIP]^2＋ have been synthesized and their structures have been ascertained with elemental analysis and nuclear magnetic resonance spectra. The characteristics of the interaction of the complexes with CT-DNA were examined by Ultra-Vis absorption spectra, fluorescent spectra, viscosity measurements and gel electrophoresis technique. All data indicate that both complexes bind to double-stranded CT-DNA via the intercalative mode and [Ru(bpy)₂DMNP]^2＋ binds more avidly to CT-DNA than [Ru(bpy)₂BOPIP]^2＋. Noticeably, upon irradiation at 365 nm, the two complexes have been found to efficiently photocleave plasmid DNA, and the active oxygen species for the DNA cleavage in these complexes is singlet molecular oxygen.

Key words: polypyridyl ruthenium(II) complex, DNA, photocleavage, intercalation

Cite this article

PU Xiao-Hua^1,2; CHEN Hui-Li; HAN Gao-Yi; YANG Pin*^{,1. DNA-binding and Photocleavage Studies on Polypyridyl Ruthe-nium(II) Complexes Containing Steric Hinderance Group[J]. Acta Chimica Sinica, 2007, 65(15): 1464-1468.}

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带有位阻基团的钌多吡啶配合物与DNA键合及其光断裂DNA性质的研究

DNA-binding and Photocleavage Studies on Polypyridyl Ruthe-nium(II) Complexes Containing Steric Hinderance Group

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