Fifteen new diacyl thioureas with asymmetric structure (compounds 6 and 6') and nine new monoacyl thioureas containing amido group in molecules (compounds 7 and 7') were synthesized by the techniques of ultrasonic irradiation and phase transfer catalysis for the first time. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR, APT, 1D NOE, 2D NMR and elemental analysis. The downfield proton and carbon signals in ¹H NMR and ¹³C NMR spectra have been assigned. The results of screening tests for bactericidal activity, insecticidal activity and herbicidal activity indicated that the target compounds possessed relatively high inhibiting activity against Cl-colletotrichum lagenariun and the compound 6e had the highest inhibition rate, up to 62.4%. The target compound 7a exhibits inhibiting activity against Sf-sphaerotheca fuliginea. Monoamine oxidase activity test showed that most of the target compounds possessed inhibiting activity against monoamine oxidase and the compounds 6'c and 6'd displayed quite higher inhibiting activity than the others at the concentration of 1×10^－3 mol•L^－1. The target compounds did not possess anticonvulasional activity.

Key words: acylthiourea, synthesis, ultrasonic irradiation and phase transfer catalysis, biological activity