Study on the Release Process of Drug-containing PMMA Film by Two-dimensional UV-Vis Correlation Spectroscopy

Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (10): 1265-1268. Previous Articles Next Articles

Original Articles

二维紫外相关光谱研究复方载药PMMA膜的释放过程

江艳，武培怡*

(复旦大学高分子科学系聚合物分子工程教育部重点实验室上海 200433)

投稿日期:2007-06-28 修回日期:2007-10-24 发布日期:2008-05-28
通讯作者: 武培怡

Study on the Release Process of Drug-containing PMMA Film by Two-dimensional UV-Vis Correlation Spectroscopy

JIANG, Yan, WU, Pei-Yi*

(Key Laboratory of Molecular Engineering of Polymers (Ministry of Education) and Department of Macromolecular Science, Fudan University, Shanghai 200433)

Received:2007-06-28 Revised:2007-10-24 Published:2008-05-28
Contact: WU, Pei-Yi

Abstract

UV-Vis spectroscopy was utilized to monitor the release process of ibuprofen and piroxicam from PMMA film in the phosphate-buffered saline (PBS). Both of the drugs maintained a continuous release process under time perturbation. Furthermore, two-dimensional UV correlation spectroscopy was applied to explore the sequence of the drug release and it was implied that hydrogen-bonding interaction was formed between ibuprofen and poly (methyl methacrylate (PMMA), which was responsible for the lower speed of release. FTIR spectra of drug-containing PMMA film confirmed the existence of the interaction and the potential applications of two-dimensional UV correlation spectroscopy in drug release have been confirmed.

Key words: ibuprofen, piroxicam, PMMA, drug release, two-dimensional UV correlation spectroscopy

Cite this article

JIANG, Yan, WU, Pei-Yi*. Study on the Release Process of Drug-containing PMMA Film by Two-dimensional UV-Vis Correlation Spectroscopy[J]. Acta Chimica Sinica, 2008, 66(10): 1265-1268.

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二维紫外相关光谱研究复方载药PMMA膜的释放过程

Study on the Release Process of Drug-containing PMMA Film by Two-dimensional UV-Vis Correlation Spectroscopy

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