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Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (12): 1451-1454. Previous Articles     Next Articles

西红花酸的合成

张俊国a,b 张 宏*,a,c 张 伶d 颜 钫c 陈 放c   

  1. (a四川师范大学生命科学院 成都 610068)
    (b四川师范大学化学与材料学院 成都 610068)
    (c四川大学生命科学学院 成都 610064)
    (d四川大学肿瘤生物治疗中心 成都 610041)
  • 投稿日期:2007-10-30 修回日期:2008-01-25 发布日期:2008-06-28
  • 通讯作者: 张宏

Synthesis of Crocetin

ZHANG, Jun-Guo a,b ZHANG, Hong *,a,c ZHANG, Ling d YAN, Fang c CHEN, Fang c   

  1. (a College of Life Science, Sichuan Normal University, Chengdu 610068)
    (b College of Chemistry and Materials, Sichuan Normal University, Chengdu 610068)
    (c College of Life Science, Sichuan University, Chengdu 610064)
    (d Center of Tumour Biological Therapeutic, Sichuan University, Chengdu 610041)
  • Received:2007-10-30 Revised:2008-01-25 Published:2008-06-28
  • Contact: ZHANG, Hong

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In this paper we describe an efficient seven-step synthesis of crocetin through the use of in situ procedures. Firstly, crocetin-dimethylester was synthesized by the Wittig-Horner reaction with two compounds 2,7-dimethyl-2,4,6-oct-triene-1,8-dialdehyde and methyl O,O-diethyl-γ-phosphonotiglate. Crocetin- dimethylester was then converted into crocetin.

Key words: Wittig-Horner reaction, crocetin-dimethylester., crocetin, synthesis