Synthesis and Biological Activities of 4,5-Dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione Schiff Bases

Abstract

Thiocarbazide was reacted with acetic acid to prepare 4,5-dihydro-3-methyl-4-amino-1,2, 4-triazole-5-thione. Then eight Schiff bases were synthesized using this 1,2,4-triazole-5-thione and substituted aromatic aldehydes as starting materials, with acetic acid as a catalyst and solvent. The structures of all the compounds have been confirmed by ¹H NMR, IR and elemental analysis. Their biological activities to several vegetable pathogens have been tested and the results showed that they exhibited good fungicidal activities.

Key words: Schiff base, triazolethione, synthesis, biological activity

Cite this article

SUN Xiao-Hong*^,1 TAO Yan LIU Yuan-Fa² JIA Ying-Qi² CHEN Bang^{2. Synthesis and Biological Activities of 4,5-Dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione Schiff Bases[J]. Acta Chimica Sinica, 2008, 66(2): 234-238.}

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