Synthesis, Characterization and Properties of Phosphorylcholine Functionalized Poly(butylene succinate)

Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (16): 1903-1909. Previous Articles Next Articles

Original Articles

末端带有磷酰胆碱基团的聚丁二酸丁二醇酯的合成、表征和性能研究

张世平朱霞霞宫永宽*

(西北大学化学与材料科学学院合成与天然功能分子化学教育部重点实验室西安 710069)

投稿日期:2009-01-11 修回日期:2009-03-16 发布日期:2009-08-28
通讯作者: 宫永宽

Synthesis, Characterization and Properties of Phosphorylcholine Functionalized Poly(butylene succinate)

Zhang, Shiping Zhu, Xiaxia Gong, Yongkuan*

(Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry & Materials Science, Northwest University, Xi’an 710069)

Received:2009-01-11 Revised:2009-03-16 Published:2009-08-28
Contact: Gong, Yongkuan

Abstract

A new biodegradable and biocompatible polymer, phosphorylcholine functionalized poly(butylene succinate) (PBS-PC) was synthesized via a four-step synthetic strategy. The results of 1H NMR, IR, gel permeation chromatography (GPC) and X-ray photoelectron spectroscopy (XPS) measurements demonstrated a successful construction of PBS-PC. Dynamic contact angle, in vitro degradation, swelling behavior and drug release measurements revealed that the PBS-PC showed higher hydrophilicity, degradation, swelling and faster drug release rates by using neutral red as a model drug.

Key words: poly(butylene succinate), phosphorylcholine, in vitro degradation, swelling behavior, neutral red, drug release

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末端带有磷酰胆碱基团的聚丁二酸丁二醇酯的合成、表征和性能研究

Synthesis, Characterization and Properties of Phosphorylcholine Functionalized Poly(butylene succinate)

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