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Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (11): 1070-1076. Previous Articles     Next Articles

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新型β-取代阳离子卟啉光敏剂合成及其与DNA相互作用

黄齐茂，邓鹏星，李志远，周红，胡学雷，潘志权*   

  1. 武汉工程大学 绿色化工过程省部共建教育部重点实验室 武汉 430073
  • 投稿日期:2009-09-25 修回日期:2010-01-03 发布日期:2010-01-26
  • 通讯作者: 潘志权

Synthesis of Novel β-Substituted Cationic Porphyrins as Photosensitizer and Their Interactions with DNA

HUANG Qi-Mao, DENG Peng-Xing, LI Zhi-Yuan, ZHOU Hong, HU Xue-Lei, PAN Zhi-Quan   

  1. Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073
  • Received:2009-09-25 Revised:2010-01-03 Published:2010-01-26

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β-{2-[6-(1-pyridyl)hexoxy]}naphthyl-5,10,15,20-tetraphenylporphyrin and its Cu(II), Ni(II), Zn(II) complexes have been synthesized by means of introducing pyridinium to 5,10,15,20-tetraphenyl- porphyrin at β-pyrrolic position, and structurally characterized by IR, UV, 1H NMR, MS and elemental analysis. Their interactions with pBR322 DNA have been investigated. The results suggest that these novel porphyrins, as potential photodynamic therapy (PDT) photosensitizer, have both photosensitive cleavage and binding effects on DNA. Furthermore, the binding mode has been studied through the test of their interactions with calf thymus DNA (CT DNA).

Key words: β-substituted cationic porphyrins, pyridinium bromide, photosensitizer, synthesis, interactions with DNA

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