Structure and Properties Regulation of Organic Photosensitizers and Application in Photodiagnosis and Treatment★

doi:10.6023/A23050243

Acta Chimica Sinica ›› 2023, Vol. 81 ›› Issue (11): 1642-1662.DOI: 10.6023/A23050243 Previous Articles Next Articles

Special Issue: 庆祝《化学学报》创刊90周年合辑

Review

有机光敏剂结构与性能调控及其光诊疗应用^★

闫英红^a, 梁平兆^a, 邹杨^b, 袁林^a^,^*(), 彭孝军^b, 樊江莉^b^,^*(), 张晓兵^a^,^*()

a 湖南大学化学化工学院化学生物传感与计量学国家重点实验室长沙 410082
b 大连理工大学化工学院精细化工国家重点实验室智能材料化工前沿科学中心辽宁大连 116024

投稿日期:2023-05-20 发布日期:2023-07-17

作者简介:

闫英红, 湖南大学化学化工学院在读硕士研究生, 导师是张晓兵教授与尹霞教授, 研究方向是近红外小分子荧光探针对肿瘤的成像与治疗.

梁平兆, 湖南大学化学化工学院在读博士研究生, 导师是张晓兵教授. 研究方向是用于肿瘤治疗的可激活光学探针的设计与应用.

邹杨, 大连理工大学化工学院在读博士研究生, 导师是樊江莉教授. 研究方向是有机光敏染料设计及其在肿瘤光疗中的应用.

袁林, 博士, 现任湖南大学化学与化工学院教授、博士生导师. 主要从事荧光染料性能调控、小分子荧光探针设计及应用方向的研究.

彭孝军, 博士, 大连理工大学化工学院教授, 中国科学院院士. 国家杰出青年基金获得者, 教育部“长江学者”特聘教授、国务院学科评议组成员. 主要从事精细化工研究, 包括高性能染料、荧光探针、光学材料, 在数码彩色打印等领域获得产业化应用.

樊江莉, 博士, 现任大连理工大学化工学院教授, 博士生导师. 国家杰出青年基金获得者, 国家“万人计划”科技创新领军人才. 主要从事精细化工研究, 包括高性能染料、光学材料等, 在血液细胞分析系统等领域获得产业化应用.

张晓兵, 博士, 湖南大学教授, 现任化学化工学院院长、化学生物传感与计量学国家重点实验室副主任. 长江学者特聘教授、国家杰出青年科学基金获得者、国家“万人计划”科技创新领军人才. 研究方向主要集中在高性能荧光探针开发及其生物医学应用.

^★庆祝《化学学报》创刊90周年.

基金资助:
国家自然科学基金重点项目(22234003)

Structure and Properties Regulation of Organic Photosensitizers and Application in Photodiagnosis and Treatment^★

Yinghong Yan^a, Pingzhao Liang^a, Yang Zou^b, Lin Yuan^a(), Xiaojun Peng^b, Jiangli Fan^b(), Xiaobing Zhang^a()

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082
b State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, College of Chemical Engineering, Dalian University of Technology, Dalian 116024

Received:2023-05-20 Published:2023-07-17
Contact: *E-mail: lyuan@hnu.edu.cn; fanjl@dlut.edu.cn; xbzhang@hnu.edu.cn
About author:
^★Dedicated to the 90th anniversary of Acta Chimica Sinica.
Supported by:
Key Program of National Natural Science Foundation of China(22234003)

Photodynamic therapy (PDT), as an efficient treatment method, has the advantages of low toxicity, non-invasiveness and controllability, which has been widely used in the treatment of proliferative skin diseases and tumors. However, the reported PDT photosensitizers still face many challenges in practical biological applications, such as the efficacy of PDT is significantly reduced by the tumor hypoxic environment; the poor targeting of photosensitizers can easily cause damage to normal tissues. In order to solve the above problems, researchers have proposed many effective strategies to improve the therapeutic efficacy of organic photosensitizers. Herein, the structure and property regulation strategies of organic photosensitizers are reviewed. In addition, the practical applications of photosensitizers in antitumor, antibacterial therapy, and afterglow imaging are introduced. In the end, the design strategies of organic small molecule photosensitizers are summarized and prospected in order to promote the development of this field.

Key words: photosensitizers, organic dyes, photodynamic therapy, theranostics, imaging

Cite this article

Yinghong Yan, Pingzhao Liang, Yang Zou, Lin Yuan, Xiaojun Peng, Jiangli Fan, Xiaobing Zhang. Structure and Properties Regulation of Organic Photosensitizers and Application in Photodiagnosis and Treatment^★[J]. Acta Chimica Sinica, 2023, 81(11): 1642-1662.

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Fig. & Tab. 21

Figure 1. Schematic illustration of type I, type II, and type III PDT mechanisms

Figure 2. Summary of structure and property regulation of organic photosensitizers and their application in light diagnosis and treatment

Figure 3. Photosensitizers 1~19 based on heavy atom introduction strategy

Figure 4. (a) Schematic illustration of SOCT-ISC mechanism. (b) Photosensitizers 20~30 based on the SOCT-ISC mechanism

Figure 5. Photosensitizers 31~35 based on REISC mechanism

Figure 6. (a) D-A type photosensitizers 36~40. (b) AIE photosensitizers 41~44 containing different donor-receptors. (c) Photosensitizers 45~49 based on BODIPY skeleton

Figure 7. (a) Mechanism diagram of polymerization enhancing photosensitivity effect. (b) Polymer photosensitizers 50~55

Figure 8. Photosensitizers 56~60 containing different donor-receptors

Figure 9. (a) Photosensitizers 61~62 whose wavelength is redshifted due to J aggregation. (b) Photosensitizers 63~65 using two photon excitation. (c) Schematic diagram of two-photon excitation

Figure 10. (a) Type I photosensitizers 66~69. (b) The production mechanism of carbon free radicals of photosensitizer 70

Figure 11. Schematic diagram of hydroxyl radical produced by oxygen independent photosensitizer through photooxidation of water

Figure 12. (a) Photosensitizer 71 introducing targeting group FA. (b) Enhancing the selectivity of photosensitizers using a dual receptor mediated biological orthogonal activation method

Figure 13. Activatable photosensitizers 72~76

Figure 14. Activation process of “double lock” photosensitizer PMB

Figure 15. (a) Preparation and application diagram of BH 1024NPs. (b) Relative tumor volume of 4T1 mice after different treatments. (c) Survival rate of mice in different experimental groups. (d) H&E staining of tumors with different treatment modalities

Figure 16. (a) Schematic diagram of PDT and immunomodulation of NBS 1MT. (b) Immunofluorescence staining detection of CD8+T cells and Treg cells infiltration in 4T1 tumors. (c) Relative volume of primary tumor in mice after different treatments. (d) Relative volume of in mice after different treatments

Figure 17. (a) Schematic diagram of drug release and photosensitive activation of PNPS. (b) Local tumor response of PNPS in HCT116 tumor -bearing mice

Figure 18. (a) Structure of CS-P and schematic diagram of treatment under light. (b) Relative tumor volume changes of mice with different treatments. (c) Tumor weight of the mice with different treatment

Figure 19. (a) Structure of photosensitizer TriPE-NT. (b) Photographs of wounds treated by TriPE-NT plus white-light irradiation on day 3, day 7. (c) Schematic diagram of photosensitizer DTTPB inactivation of virus via PDT. (d) RNA expression of HCoV-229E virus

Figure 20. (a) Fluorescence and afterglow luminescence images of tumor and skin after local injection of SPN. (b) Fluorescence and afterglow intensities of tumor and skin after local injection of SPN

Figure 21. (a) Molecular design and afterglow mechanism of MAP. (b) Fluorescence and afterglow images of living mice after injection of MAP-$\mathop{{O}}_{2}^{{\mathop{}^{-·}}}$ at different time points. (c) Fluorescence and afterglow intensities of liver areas after injection of MAP-$\mathop{{O}}_{2}^{{\mathop{}^{-·}}}$. (d) SBR for fluorescence and afterglow of liver areas after injection of MAP-$\mathop{{O}}_{2}^{{\mathop{}^{-·}}}$

References 107

[1]	Li H. D.; Kim D.; Yao Q. C.; Ge H. Y.; Chung J.; Fan J. L.; Wang J. Y.; Peng X. J.; Yoon J. Angew. Chem., Int. Ed. 2021, 60, 17268. doi: 10.1002/anie.v60.32
[2]	Luby B. M.; Walsh C. D.; Zheng G. Angew. Chem., Int. Ed. 2019, 58, 2558. doi: 10.1002/anie.v58.9
[3]	Zhao X. Z.; Liu J. P.; Fan J. L.; Chao H.; Peng X. J. Chem. Soc. Rev. 2021, 50, 4185. doi: 10.1039/D0CS00173B
[4]	Lucky S. S.; Soo K. C.; Zhang Y. Chem. Rev. 2015, 115, 1990. doi: 10.1021/cr5004198
[5]	Li S. K.; Zou Q. L.; Li Y. X.; Yuan C. Q.; Xing R. R.; Yan X. H. J. Am. Chem. Soc. 2018, 140, 10794. doi: 10.1021/jacs.8b04912
[6]	Zhu L.; Luo M.; Zhang Y.; Fang F.; Li M.; An F.; Zhao D.; Zhang J. Coord. Chem. Rev. 2023, 475, 214875. (in Chinese) doi: 10.1016/j.ccr.2022.214875
[7]	Lü X.; Wu Y.; Zhang B. R.; Guo W. Acta Chim. Sinica 2023, 81, 359. (in Chinese) doi: 10.6023/A22120487
	( 吕鑫, 吴仪, 张勃然, 郭炜, 化学学报, 2023, 81, 359.) doi: 10.6023/A22120487
[8]	Li X.; Lee S.; Yoon J. Chem. Soc. Rev. 2018, 47, 1174. doi: 10.1039/C7CS00594F
[9]	Dang J.; He H.; Chen D.; Yin L. Biomater. Sci. 2017, 5, 1500. doi: 10.1039/C7BM00392G
[10]	Nguyen V. N.; Qi S.; Kim S.; Kwon N.; Kim G.; Yim Y.; Park S.; Yoon J. J. Am. Chem. Soc. 2019, 141, 16243. doi: 10.1021/jacs.9b09220
[11]	Xu K.; Zhang T.; Shao J. J.; Dong X. C. Chinese Journal of Lasers 2023, 50, 0307202. (in Chinese) doi: 10.3788/CJL
	( 许康, 张甜, 邵进军, 董晓臣, 中国激光, 2023, 50, 0307202.)
[12]	Qi G. B.; Hu F.; Kenry; Shi L. L.; Wu M.; Liu B. Angew. Chem., Int. Ed. 2019, 58, 16229. doi: 10.1002/anie.v58.45
[13]	Yao C.; Wang W.; Wang P.; Zhao M.; Li X.; Zhang F. Adv. Mater. 2018, 30, 1704833. doi: 10.1002/adma.v30.7
[14]	Wang H.; Han X.; Dong Z.; Xu J.; Wang J.; Liu Z. Adv. Funct. Mater. 2019, 29, 1902440. doi: 10.1002/adfm.v29.29
[15]	Li X.; Chen L.; Huang M.; Zeng S.; Zheng J.; Peng S.; Wang Y.; Cheng H.; Li S. Asian J. Pharm. Sci. 2023, 18, 100775.
[16]	Allison R. R.; Sibata C. H. Photodiagn. Photodyn. 2010, 7, 61. doi: 10.1016/j.pdpdt.2010.02.001
[17]	Yao Q.; Fan J.; Long S.; Zhao X.; Li H.; Du J.; Shao K.; Peng X. Chem 2022, 8, 197. doi: 10.1016/j.chempr.2021.10.006
[18]	Liu Z.; Cao T.; Xue Y.; Li M.; Wu M.; Engle J. W.; He Q.; Cai W.; Lan M.; Zhang W. Angew. Chem., Int. Ed. 2020, 59, 3711. doi: 10.1002/anie.v59.9
[19]	Zhou Z.; Song J.; Nie L.; Chen X. Chem. Soc. Rev. 2016, 45, 6597. doi: 10.1039/C6CS00271D
[20]	Chinna Ayya Swamy P.; Sivaraman G.; Priyanka R. N.; Raja S. O.; Ponnuvel K.; Shanmugpriya J.; Gulyani A. Coord. Chem. Rev. 2020, 411, 213233. doi: 10.1016/j.ccr.2020.213233
[21]	Han K.; Wang S. B.; Lei Q.; Zhu J. Y.; Zhang X. Z. ACS Nano 2015, 9, 10268. doi: 10.1021/acsnano.5b04243
[22]	Turan I. S.; Yildiz D.; Turksoy A.; Gunaydin G.; Akkaya E. U. Angew. Chem., Int. Ed. 2016, 55, 2875. doi: 10.1002/anie.v55.8
[23]	Huang L.; Li Z.; Zhao Y.; Zhang Y.; Wu S.; Zhao J.; Han G. J. Am. Chem. Soc. 2016, 138, 14586. pmid: 27786443
[24]	Zou J.; Yin Z.; Ding K.; Tang Q.; Li J.; Si W.; Shao J.; Zhang Q.; Huang W.; Dong X. ACS Appl. Mater. Interfaces. 2017, 9, 32475. doi: 10.1021/acsami.7b07569
[25]	Zhai W.; Zhang Y.; Liu M.; Zhang H.; Zhang J.; Li C. Angew. Chem., Int. Ed. 2019, 58, 16601. doi: 10.1002/anie.v58.46
[26]	Karges J.; Basu U.; Blacque O.; Chao H.; Gasser G. Angew. Chem., Int. Ed. 2019, 58, 14334. doi: 10.1002/anie.v58.40
[27]	Wen K.; Tan H.; Peng Q.; Chen H.; Ma H.; Wang L.; Peng A.; Shi Q.; Cai X.; Huang H. Adv. Mater. 2022, 34, 2108146. doi: 10.1002/adma.v34.7
[28]	Ma D. D.; Bian H.; Long S. R.; Zhou P. W.; Tian R. S.; Wu Y.N.; Ge H. Y.; Li M. L.; Du J. J.; Fan J. L.; Zhang Y. K.; Peng X. J. Sci. China Chem. 2022, 65, 563. doi: 10.1007/s11426-021-1179-7
[29]	Yao S.; Chen Y.; Ding W.; Xu F.; Liu Z.; Li Y.; Wu Y.; Li S.; He W.; Guo Z. Chem. Sci. 2023, 14, 1234. doi: 10.1039/D2SC05982G
[30]	Nguyen V.-N.; Yan Y.; Zhao J.; Yoon J. Acc. Chem. Res. 2021, 54, 207. doi: 10.1021/acs.accounts.0c00606
[31]	Filatov M. A. Ogr. Biomol. Chem. 2020, 18, 10.
[32]	Filatov M. A.; Karuthedath S.; Polestshuk P. M.; Savoie H.; Flanagan K. J.; Sy C.; Sitte E.; Telitchko M.; Laquai F.; Boyle R. W.; Senge M. O. J. Am. Chem. Soc. 2017, 139, 6282. doi: 10.1021/jacs.7b00551
[33]	Lv M.; Yu Y.; Sandoval-Salinas M. E.; Xu J. H.; Lei Z. H.; Casanova D.; Yang Y. J.; Chen J. Q. Angew. Chem., Int. Ed. 2020, 59, 22179. doi: 10.1002/anie.v59.49
[34]	Zhao X.; Yao Q.; Long S.; Chi W.; Yang Y.; Tan D.; Liu X.; Huang H.; Sun W.; Du J.; Fan J. L.; Peng X. J. J. Am. Chem. Soc. 2021, 143, 12345. doi: 10.1021/jacs.1c06275
[35]	Miao J.; Huo Y.; Yao G.; Feng Y.; Weng J.; Zhao W.; Guo W. Angew. Chem., Int. Ed. 2022, 61, e202201815. doi: 10.1002/anie.v61.25
[36]	Yuan Z.; Yu S.; Cao F.; Mao Z.; Gao C.; Ling J. Polym. Chem. 2018, 9, 2124. doi: 10.1039/C8PY00289D
[37]	Martins S.; Farinha J. P. S.; Baleizão C.; Berberan-Santos M. N. Chem. Commun. 2014, 50, 3317. doi: 10.1039/c3cc48293f
[38]	Kim S.; Zhou Y.; Tohnai N.; Nakatsuji H.; Matsusaki M.; Fujitsuka M.; Miyata M.; Majima T. Chem. Eur. J. 2018, 24, 636. doi: 10.1002/chem.v24.3
[39]	Zou J.; Li L.; Zhu J.; Li X.; Yang Z.; Huang W.; Chen X. Adv. Mater. 2021, 33, 2103627. doi: 10.1002/adma.v33.44
[40]	Zhao P.; Wang Z.; Wang Y.; Wu Z.; Guo Y.; Wang C.; Fang X.; Qu Z.; Wang H.; Zhao G. Dyes Pigments 2023, 214, 111214. doi: 10.1016/j.dyepig.2023.111214
[41]	Likhtenstein G. I.; Ishii K.; Nakatsuji S. I. Photochem. Photobiol. 2007, 83, 871. pmid: 17645658
[42]	Cui X.; Zhang Z.; Yang Y.; Li S.; Lee C.-S. Exploration 2022, 2, 20210264. doi: 10.1002/exp2.v2.2
[43]	Wang Z.; Zhao J.; Barbon A.; Toffoletti A.; Liu Y.; An Y.; Xu L.; Karatay A.; Yaglioglu H. G.; Yildiz E. A.; Hayvali M. J. Am. Chem. Soc. 2017, 139, 7831. doi: 10.1021/jacs.7b02063
[44]	Wang Z.; Gao Y.; Hussain M.; Kundu S.; Rane V.; Hayvali M.; Yildiz E. A.; Zhao J.; Yaglioglu H. G.; Das R.; Luo L.; Li J. F. Chem. Eur. J. 2018, 24, 18663. doi: 10.1002/chem.v24.70
[45]	Jiao L.; Song F.; Cui J.; Peng X. Chem. Commun. 2018, 54, 9198. doi: 10.1039/C8CC04582H
[46]	Xu F.; Ge H.; Xu N.; Yang C.; Yao Q.; Long S.; Sun W.; Fan J.; Xu X.; Peng X. Sci. China Chem. 2021, 64, 488. doi: 10.1007/s11426-020-9922-3
[47]	Zhang C.; Zhao Y.; Li D.; Liu J.; Han H.; He D.; Tian X.; Li S.; Wu J.; Tian Y. Chem. Commun. 2019, 55, 1450. doi: 10.1039/C8CC09230C
[48]	Zheng Z.; Liu H.; Zhai S.; Zhang H.; Shan G.; Kwok R. T. K.; Ma C.; Sung H. H. Y.; Williams I. D.; Lam J. W. Y.; Wong K. S.; Hu X. L.; Tang B. Z. Chem. Sci. 2020, 11, 2494. doi: 10.1039/c9sc06441a pmid: 34084415
[49]	Nguyen V.-N.; Yim Y.; Kim S.; Ryu B.; Swamy K. M. K.; Kim G.; Kwon N.; Kim C.-Y.; Park S.; Yoon J. Angew. Chem., Int. Ed. 2020, 59, 8957. doi: 10.1002/anie.v59.23
[50]	Wu W.; Bazan G. C.; Liu B. Chem 2017, 2, 760. doi: 10.1016/j.chempr.2017.05.002
[51]	Wu W.; Mao D.; Hu F.; Xu S.; Chen C.; Zhang C.-J.; Cheng X.; Yuan Y.; Ding D.; Kong D.; Liu B. Adv. Mater. 2017, 29, 1700548. doi: 10.1002/adma.v29.33
[52]	Jia J.-H.; Liang D.; Yu R.; Chen X.-L.; Meng L.; Chang J.-F.; Liao J.-Z.; Yang M.; Li X.-N.; Lu C.-Z. Chem. Mater. 2020, 32, 620. doi: 10.1021/acs.chemmater.9b04585
[53]	Wu W.; Mao D.; Xu S.; Kenry; Hu F.; Li X.; Kong D.; Liu B. Chem 2018, 4, 1937. doi: 10.1016/j.chempr.2018.06.003
[54]	Wang S.; Wu W.; Manghnani P.; Xu S.; Wang Y.; Goh C. C.; Ng L. G.; Liu B. ACS Nano 2019, 13, 3095. doi: 10.1021/acsnano.8b08398
[55]	Cai Y.; Wei Z.; Song C.; Tang C.; Han W.; Dong X. Chem. Soc. Rev. 2019, 48, 22. doi: 10.1039/c8cs00494c pmid: 30444505
[56]	Xu S.; Yuan Y.; Cai X.; Zhang C.-J.; Hu F.; Liang J.; Zhang G.; Zhang D.; Liu B. Chem. Sci. 2015, 6, 5824. doi: 10.1039/C5SC01733E
[57]	Wan Y.; Lu G.; Wei W.-C.; Huang Y.-H.; Li S.; Chen J.-X.; Cui X.; Xiao Y.-F.; Li X.; Liu Y.; Meng X.-M.; Wang P; Xie H.-Y.; Zhang J.; Wong K.-T.; Lee C.-S. ACS Nano 2020, 14, 9917. doi: 10.1021/acsnano.0c02767
[58]	Li D.; Chen X.; Wang D.; Wu H.; Wen H.; Wang L.; Jin Q.; Wang D.; Ji J.; Tang B. Z. Biomaterials 2022, 283, 121476. doi: 10.1016/j.biomaterials.2022.121476
[59]	Li M.; Sun W.; Tian R.; Cao J.; Tian Y.; Gurram B.; Fan J.; Peng X. Biomaterials 2021, 269, 120532. doi: 10.1016/j.biomaterials.2020.120532
[60]	Li Y.; Ma T.; Jiang H.; Li W.; Tian D.; Zhu J.; Li Z. Angew. Chem., Int. Ed. 2022, 61, e202203093. doi: 10.1002/anie.v61.24
[61]	Gui C.; Zhao E.; Kwok R. T. K.; Leung A. C. S.; Lam J. W. Y.; Jiang M.; Deng H.; Cai Y.; Zhang W.; Su H.; Tang B. Z. Chem. Sci. 2017, 8, 1822. doi: 10.1039/C6SC04947H
[62]	Xiao Y.-F.; An F.-F.; Chen J.-X.; Yu J.; Tao W.-W.; Yu Z.; Ting R.; Lee C.-S.; Zhang X.-H. Small 2019, 15, 1903121. doi: 10.1002/smll.v15.38
[63]	McKenzie L. K.; Bryant H. E.; Weinstein J. A. Coord. Chem. Rev. 2019, 379, 2. doi: 10.1016/j.ccr.2018.03.020
[64]	Xiao Y.-F.; Chen J.-X.; Li S.; Tao W.-W.; Tian S.; Wang K.; Cui X.; Huang Z.; Zhang X.-H.; Lee C.-S. Chem. Sci. 2020, 11, 888. doi: 10.1039/C9SC05817F
[65]	Wang S.; Chen H.; Liu J.; Chen C.; Liu B. Adv. Funct. Mater. 2020, 30, 2002546. doi: 10.1002/adfm.v30.30
[66]	Piao W.; Hanaoka K.; Fujisawa T.; Takeuchi S.; Komatsu T.; Ueno T.; Terai T.; Tahara T.; Nagano T.; Urano Y. J. Am. Chem. Soc. 2017, 139, 13713. doi: 10.1021/jacs.7b05019 pmid: 28872304
[67]	Chen Q.; Feng L.; Liu J.; Zhu W.; Dong Z.; Wu Y.; Liu Z. Adv. Mater. 2016, 28, 7129. doi: 10.1002/adma.v28.33
[68]	Sun J.; Du K.; Diao J.; Cai X.; Feng F.; Wang S. Angew. Chem., Int. Ed. 2020, 59, 12122. doi: 10.1002/anie.v59.29
[69]	Zhang C.; Zhao K.; Bu W.; Ni D.; Liu Y.; Feng J.; Shi J. Angew. Chem., Int. Ed. 2015, 54, 1770. doi: 10.1002/anie.v54.6
[70]	Li M.; Xia J.; Tian R.; Wang J.; Fan J.; Du J.; Long S.; Song X.; Foley J. W.; Peng X. J. Am. Chem. Soc. 2018, 140, 14851. doi: 10.1021/jacs.8b08658
[71]	Li M.; Shao Y.; Kim J. H.; Pu Z.; Zhao X.; Huang H.; Xiong T.; Kang Y.; Li G.; Shao K.; Fan J. L.; Foley J. W.; Kim J. S.; Peng X. J. J. Am. Chem. Soc. 2020, 142, 5380. doi: 10.1021/jacs.0c00734
[72]	Teng K.-X.; Chen W.-K.; Niu L.-Y.; Fang W.-H.; Cui G.; Yang Q.-Z. Angew. Chem., Int. Ed. 2021, 60, 19912. doi: 10.1002/anie.v60.36
[73]	Teng K.-X.; Niu L.-Y.; Yang Q.-Z. Chem. Sci. 2022, 13, 5951. doi: 10.1039/D2SC01469F
[74]	Teng K.-X.; Niu L.-Y.; Xie N.; Yang Q.-Z. Nat. Commun. 2022, 13, 6179. doi: 10.1038/s41467-022-33924-3
[75]	Chen W.; Wang Z.; Tian M.; Hong G.; Wu Y.; Sui M.; Chen M.; An J.; Song F.; Peng X. J. Am. Chem. Soc. 2023, 145, 8130. doi: 10.1021/jacs.3c01042
[76]	Kuang S.; Sun L.; Zhang X.; Liao X.; Rees T. W.; Zeng L.; Chen Y.; Zhang X.; Ji L.; Chao H. Angew. Chem., Int. Ed. 2020, 59, 20697. doi: 10.1002/anie.v59.46
[77]	Teng K.-X.; Niu L.-Y.; Yang Q.-Z. J. Am. Chem. Soc. 2023, 145, 4081. doi: 10.1021/jacs.2c11868
[78]	Vankayala R.; Kuo C.-L.; Nuthalapati K.; Chiang C.-S.; Hwang K. C. Adv. Funct. Mater. 2015, 25, 5934. doi: 10.1002/adfm.v25.37
[79]	Kuthala N.; Vankayala R.; Li Y.-N.; Chiang C.-S.; Hwang K. C. Adv. Mater. 2017, 29, 1700850. doi: 10.1002/adma.v29.31
[80]	Ho L.-C.; Wu W.-C.; Chang C.-Y.; Hsieh H.-H.; Lee C.-H.; Chang H.-T. Anal. Chem. 2015, 87, 4925. doi: 10.1021/acs.analchem.5b00569
[81]	Fang J.; Islam W.; Maeda H. Adv. Drug Delivery. Rev. 2020, 157, 142. doi: 10.1016/j.addr.2020.06.005
[82]	Zhao R.; Wang B.; Yang X.; Xiao Y.; Wang X.; Shao C.; Tang R. Angew. Chem., Int. Ed. 2016, 55, 5225. doi: 10.1002/anie.v55.17
[83]	Yang M.; Deng J.; Guo D.; Zhang J.; Yang L.; Wu F. Ogr. Biomol. Chem. 2019, 17, 5367.
[84]	Chu J. C. H.; Wong C. T. T.; Ng D. K. P. Angew. Chem., Int. Ed. 2023, 62, e202214473. doi: 10.1002/anie.v62.2
[85]	Chu J. C. H.; Fong W.-P.; Wong C. T. T.; Ng D. K. P. J. Med. Chem. 2021, 64, 2064. doi: 10.1021/acs.jmedchem.0c01677
[86]	Lovell J. F.; Liu T. W. B.; Chen J.; Zheng G. Chem. Rev. 2010, 110, 2839. doi: 10.1021/cr900236h
[87]	Gamcsik M. P.; Kasibhatla M. S.; Teeter S. D.; Colvin O. M. Biomarkers 2012, 17, 671. doi: 10.3109/1354750X.2012.715672
[88]	Hu F.; Yuan Y.; Mao D.; Wu W.; Liu B. Biomaterials 2017, 144, 53. doi: 10.1016/j.biomaterials.2017.08.018
[89]	Li X.; Kolemen S.; Yoon J.; Akkaya E. U. Adv. Funct. Mater. 2017, 27, 1604053. doi: 10.1002/adfm.v27.5
[90]	Xiong H.; Zhou K. J.; Yan Y. F.; Miller J. B.; Siegwart D. J. ACS Appl. Mater. Interfaces 2018, 10, 16335. doi: 10.1021/acsami.8b04710
[91]	Yuan B.; Wang H.; Xu J.-F.; Zhang X. ACS Appl. Mater. Interfaces 2020, 12, 26982. doi: 10.1021/acsami.0c07471
[92]	Chen Y.; Zhao X.; Xiong T.; Du J.; Sun W.; Fan J.; Peng X. Sci. Chi. Chem. 2021, 64, 808.
[93]	Wei X.; Zhang C.; He S.; Huang J.; Huang J.; Liew S. S.; Zeng Z.; Pu K. Angew. Chem., Int. Ed. 2022, 61, e202202966. doi: 10.1002/anie.v61.26
[94]	Xu F.; Li H.; Yao Q.; Ge H.; Fan J.; Sun W.; Wang J.; Peng X. Chem. Sci. 2019, 10, 10586. doi: 10.1039/C9SC03355F
[95]	Tam L. K. B.; Chu J. C. H.; He L.; Yang C.; Han K.-C.; Cheung P. C. K.; Ng D. K. P.; Lo P.-C. J. Am. Chem. Soc. 2023, 145, 7361. doi: 10.1021/jacs.2c13732
[96]	Chen K.; Zhang R.; Wang Z.; Zhang W.; Tang B. Z. Adv. Opt. Mater. 2020, 8, 1901433. doi: 10.1002/adom.v8.2
[97]	Bian H.; Ma D.; Zhang X.; Xin K.; Yang Y.; Peng X.; Xiao Y. Small 2021, 17, 2100398. doi: 10.1002/smll.v17.21
[98]	Lu Y.; Xu F.; Wang Y.; Shi C.; Sha Y.; He G.; Yao Q.; Shao K.; Sun W.; Du J.; Fan J. L.; Peng X. J. Biomaterials 2021, 278, 121167. doi: 10.1016/j.biomaterials.2021.121167
[99]	Liu H.-W.; Hu X.-X.; Li K.; Liu Y.; Rong Q.; Zhu L.; Yuan L.; Qu F.-L.; Zhang X.-B.; Tan W. Chem. Sci. 2017, 8, 7689. doi: 10.1039/C7SC03454G
[100]	Yuan J.; Zhou Q.-H.; Xu S.; Zuo Q.-P.; Li W.; Zhang X.-X.; Ren T.-B.; Yuan L.; Zhang X.-B. Angew. Chem., Int. Ed. 2022, 61, e202206169. doi: 10.1002/anie.v61.33
[101]	Li Y.; Zhao Z.; Zhang J.; Kwok R. T. K.; Xie S.; Tang R.; Jia Y.; Yang J.; Wang L.; Lam J. W. Y.; Zheng W.; Jiang X.; Tang B. Z. Adv. Funct. Mater. 2018, 28, 1804632. doi: 10.1002/adfm.v28.42
[102]	Wu M.-Y.; Gu M.; Leung J.-K.; Li X.; Yuan Y.; Shen C.; Wang L.; Zhao E.; Chen S. Small 2021, 17, 2101770. doi: 10.1002/smll.v17.30
[103]	Li J.; Pu K. Chem. Soc. Rev. 2019, 48, 38. doi: 10.1039/C8CS00001H
[104]	Xu Y.; Yang W.; Yao D.; Bian K.; Zeng W.; Liu K.; Wang D.; Zhang B. Chem. Sci. 2020, 11, 419. doi: 10.1039/c9sc04901k pmid: 32190262
[105]	Cui D.; Xie C.; Li J.; Lyu Y.; Pu K. Adv. Healthcare Mater. 2018, 7, 1800329. doi: 10.1002/adhm.v7.18
[106]	Miao Q.; Xie C.; Zhen X.; Lyu Y.; Duan H.; Liu X.; Jokerst J. V.; Pu K. Nat. Biotechnol. 2017, 35, 1102. doi: 10.1038/nbt.3987
[107]	Liu Y.; Teng L.; Lou X.-F.; Zhang X.-B.; Song G. J. Am. Chem. Soc. 2023, 145, 5134. doi: 10.1021/jacs.2c11466

有机光敏剂结构与性能调控及其光诊疗应用^★

Structure and Properties Regulation of Organic Photosensitizers and Application in Photodiagnosis and Treatment^★

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有机光敏剂结构与性能调控及其光诊疗应用★

Structure and Properties Regulation of Organic Photosensitizers and Application in Photodiagnosis and Treatment★

RichHTML

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Knowledge

Abstract

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Fig. & Tab. 21

References 107

Related Articles 15

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有机光敏剂结构与性能调控及其光诊疗应用^★

Structure and Properties Regulation of Organic Photosensitizers and Application in Photodiagnosis and Treatment^★