Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (14): 1343-1348.     Next Articles

Full Papers

1,4-二羟基蒽醌及其Y3+配位聚合物与DNA相互作用研究

殷卫峰,欧植泽*,高云燕*,郝平,郭创龙,王中丽   

  1. (西北工业大学理学院应用化学系 西安 710072)
  • 投稿日期:2010-04-04 修回日期:2010-05-25 发布日期:2010-06-12
  • 通讯作者: 欧植泽 E-mail:ouzhize@nwpu.edu.cn
  • 基金资助:

    竹红菌素衍生物与血浆蛋白质作用的构效关系研究;环糊精包结作用对功能化富勒烯C60光化学性质的影响;碳纳米材料/核黄素的能量传递和电子转移反应调控研究;功能化富勒烯的簇集行为对其光化学性质的影响

Interaction of 1,4-Dihydroxyanthraquinone and Its Yttrium Coordination Polymer with DNA

YIN Wei-Feng, OU Zhi-Ze , GAO Yun-Yan-*, HAO Ping, GUO Chuang-Long, WANG Zhong-Li   

  1. (Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi an 710072)
  • Received:2010-04-04 Revised:2010-05-25 Published:2010-06-12
  • Contact: Ou Zhize E-mail:ouzhize@nwpu.edu.cn

The interaction of 1,4-dihydroxyanthraquinone (DHA) with Y3+ was studied by UV-Vis, 1H NMR, and FTIR. Y3+ and DHA can form one-dimensional chain coordination polymer Y-DHA with a 1∶1 stoichiometry. Y-DHA possesses better water solubility and shows stronger absorption in visible region than DHA. The interaction of Y-DHA and DHA with CT DNA was studied by UV-Vis, fluorescence spectra, and DNA melting temperature experiments. The results indicate that the groove binding and electrostatic interaction are the major modes for the association of Y-DHA with CT DNA, while groove binding is the mainly mode for the interaction of DHA with CT DNA. Voltammetry studies demonstrate that the reduction potential of Y-DHA (-0.324 V vs SCE) is more positive than that of DHA (-0.387 V vs SCE). Under anaerobic conditions, Y-DHA shows stronger DNA photocleavage ability than DHA.

Key words: anthraquinone, coordination polymer, DNA photocleavage, photo-induced electron transfer