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Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (19): 2335-2340. Previous Articles     Next Articles

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姜黄素类铂(II)配合物的合成及其抗肿瘤活性

周双生*,1，薛璇1，姜波1，鲁传华1，田玉鹏2,3，蒋明华3   

  1. (1安徽中医学院药学院 合肥 230031)
    (2安徽大学化学化工学院 合肥 230039)
    (3山东大学晶体材料国家重点实验室 济南 250100)
  • 投稿日期:2010-11-21 修回日期:2011-04-25 发布日期:2011-06-01
  • 通讯作者: 周双生 E-mail:zshuangsheng@126.com
  • 基金资助:

    二阶/三阶非线性光学效应配合物的设计合成及其应用探索;姜黄素类铂配合物的合成及其抗肿瘤活性研究;姜黄素衍生物的合成及其光学性质研究

Synthesis and Antitumor Activities of Platinum(II) Complexes of Curcumin Analog

Zhou Shuangsheng*,1 Xue Xuan1 Jiang Bo1, Lu Chuanhua1 Tian Yupeng2,3 Jiang Minghua3   

  1. (1 School of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230031)
    (2 School of Chemistry and Chemical Engineering, Anhui University, Hefei 230039)
    (3 State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100)
  • Received:2010-11-21 Revised:2011-04-25 Published:2011-06-01

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Four kinds of platinum(II) complexes of curcumin analog (A～D) were synthesized by self-made curcumin derivatives (L1～L4) and potassium tetraiodoplatinate(II) as the starting material with ethanol as solvent. Their compositions were characterized by FT-IR, 1H NMR, MS, TG-DTA and elemental analysis. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was used to study the complexes antitumor activity in vitro against human lung adenocarcinoma cancer cell line (A549), human cervix cancer cell line (Hela) and human breast cancer cell line (MCF-7), the results showed that the complexes had strong antitumor activity against these cell lines. Inhibition of human liver tumor of A549 was examined by antitumor rate, complex A showed inhibition activity on transplanting-tumor growth of A549, 800 mg• kg－1 was as potent as cisplatin, its LD50 was 945.6 mg•kg－1.

Key words: curcumin, platinum(II) complex, synthesis, antitumor activity