Synthesis of New 1,5-benzothiazepines Containing 2-Phenyl-1,2,3- triazole and Their β-Lactams Derivatives

Acta Chimica Sinica ›› 2002, Vol. 60 ›› Issue (6): 1095-1101. Previous Articles Next Articles

Original Articles

新型含2-苯基-1,2,3-三唑基的1,5-苯并硫氮杂??及其β-内酰胺衍生物的合成

刘方明;王宝雷;张正方;孙万赋

新疆大学化学与化工学院,乌鲁木齐(830046);南开大学元素有机化学研究所. 天津(300071)

发布日期:2002-06-15

Synthesis of New 1,5-benzothiazepines Containing 2-Phenyl-1,2,3- triazole and Their β-Lactams Derivatives

Liu Fangming;Wang Baolei;Zhang Zhengfang;Sun Wanfu

College of Chemistry and Chemical Engineering, Xingjiang University, Wulumuqi(830046);Institute of Elemento-organic Chemistry, Nankai University.Tianjin(300071)

Published:2002-06-15

Abstract

1,5-benzothiazepines Containing 2-Phenyl-1,2,3-triazole (2a～2e) were synthesized from α,β-unsaturated ketones and 2-aminothiophenol. The benzothiazepines could undergo [2+2] cycloaddition reaction with ketenes generated in situ to give a series of β-lactams derivatives. The structure of products were established by IR, ~1H NMR, MS spectroscopy and elementary analysis.

Key words: BENZENETHIOL, PYRRODIAZOLE P, LACTAM, CYCLOADDITION REACTION, 1HNMR, IR, ELEMENTAL ANALYSIS, MS, BENZOTHIAZEPINE P

CLC Number:

O621

Cite this article

Liu Fangming;Wang Baolei;Zhang Zhengfang;Sun Wanfu. Synthesis of New 1,5-benzothiazepines Containing 2-Phenyl-1,2,3- triazole and Their β-Lactams Derivatives[J]. Acta Chimica Sinica, 2002, 60(6): 1095-1101.

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新型含2-苯基-1,2,3-三唑基的1,5-苯并硫氮杂??及其β-内酰胺衍生物的合成

Synthesis of New 1,5-benzothiazepines Containing 2-Phenyl-1,2,3- triazole and Their β-Lactams Derivatives

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