The porphyrins have many important biologic properties for human being. Especially, they have affinity for cancer cells. In this paper teta(para-hydroxyphenyl)porphyrin bonded methotrexatum was synthesized and characterized by UV, IR, MS+ , 'H NMR and elemental analysis. Their anticancer activities on cell level as well as in vivo of mice were tested. The experimental results indicate that the new compound shows good performance in anticancer activities, and less side effect. The mechanism of action and reasons for anticancer activities of the compound were proposed.

Key words: methotrexatum, porphyrin, ANTICARCINOGEN, IR, UV, MS