Methyl pheophorbide-a and pyropheophorbide-a were used as starting material for the synthesis of new chlorin compounds. The modifications of chemical structure along N~(21)-N~(23) axis were focused on the vinyl group at 3-position and the carbonyl group at 13~1-position. A series of pheophorbide and pyropheophorbide derivatives were synthesized and effect on their visible spectra was discussed. The structures of all new compounds were characterized by elemental analysis, UV, IR and ~1H NMR spectra.

Key words: methyl pheophorbide-a, CHEMICLAL MODIFICATION, UV, IR, 1HNMR, ELEMENTAL ANALYSIS