Studies on nucleosides. II. stereoselective synthesis of perbenzylated sugar nucleosides

Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (10): 1010-1015. Previous Articles Next Articles

Original Articles

核苷研究2: 苄基糖核苷的立体选择性合成

焦献云;乔梁;王孝伟;毛建民;蔡孟深

北京医科大学药学院

发布日期:1993-10-15

Studies on nucleosides. II. stereoselective synthesis of perbenzylated sugar nucleosides

JIAO XIANYUN;QIAO LIANG;WANG XIAOWEI;MAO JIANMIN;CAI MENGSHEN

Published:1993-10-15

Abstract

The reaction of 2,3,4,6-O-tetrabenzylpyranosyl trifluoroacetates or trichloroacetates with various representative silylated bases and nitrogen containing heterocycles in the presence of SnCl4 as catalyst were performed, and a series of new perbenzylated sugar nucleosides have been synthesized. The stereoselectivities, reactivities and yield of glycosylation reaction using trifluoroacetoxy and trichloroacetoxy group as new efficient leaving groups in the synthesis of nucleosides were discussed.

Key words: STEREOSELECTIVITY, NUCLEOSIDE, TIN TETRACHLORIDE

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JIAO XIANYUN;QIAO LIANG;WANG XIAOWEI;MAO JIANMIN;CAI MENGSHEN. Studies on nucleosides. II. stereoselective synthesis of perbenzylated sugar nucleosides[J]. Acta Chimica Sinica, 1993, 51(10): 1010-1015.

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核苷研究2: 苄基糖核苷的立体选择性合成

Studies on nucleosides. II. stereoselective synthesis of perbenzylated sugar nucleosides

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