Chemistry of hyodeoxycholic acid.8.stereoselective synthesis of (24R,25R) -24,25,26-trihydr(xycholesterol by using osmium-catalyzed asymmetric dihydroxylation of olefine

Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (6): 612-618. Previous Articles Next Articles

Original Articles

猪去氧胆酸化学 8:锇催化不对称双羟化合成 (24R,25R)-24,25,26-三羟基胆固醇

阮奔放;王钟麒

中国科学院上海有机化学研究所

发布日期:1993-06-15

Chemistry of hyodeoxycholic acid.8.stereoselective synthesis of (24R,25R) -24,25,26-trihydr(xycholesterol by using osmium-catalyzed asymmetric dihydroxylation of olefine

RUAN BENFANG;WANG ZHONGQI

Published:1993-06-15

Abstract

A stereoselective synthesis of (24R,25R)-2425,26-trihydroxycholesterol, which is an important intermediate for the synthesis of vitamin D3 analog, through 7 steps, from I (R = H) was reported. The key step is osmium-catalyzed asym. dihydroxylation of compound I (R = 4-ClC6H4CO). The total yield is 40%.

Key words: CHOLESTEROL, STEREOSELECTIVITY, OSMIUM, VITAMIN D3, HYODEOXYCHOLIC ACID, HYDROXYL COMPOUNDS

CLC Number:

R914
O629

Cite this article

RUAN BENFANG;WANG ZHONGQI. Chemistry of hyodeoxycholic acid.8.stereoselective synthesis of (24R,25R) -24,25,26-trihydr(xycholesterol by using osmium-catalyzed asymmetric dihydroxylation of olefine[J]. Acta Chimica Sinica, 1993, 51(6): 612-618.

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猪去氧胆酸化学 8:锇催化不对称双羟化合成 (24R,25R)-24,25,26-三羟基胆固醇

Chemistry of hyodeoxycholic acid.8.stereoselective synthesis of (24R,25R) -24,25,26-trihydr(xycholesterol by using osmium-catalyzed asymmetric dihydroxylation of olefine

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