Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (3): 302-307. Previous Articles     Next Articles

Original Articles

福建三尖杉碱及其类似物的半合成研究: 一个立体选择性反应的发现

王定志;马广思;徐任生   

  1. 中国科学院上海药物研究所
  • 发布日期:1993-03-15

Studies on semisynthesis of cephalofortuneine and its derivatives: Discovery of a stereoselective reaction

WANG DINGZHI;MA ANSI;XU RENSHENG   

  • Published:1993-03-15

During studies on semisynthesis from epiwilsonine (I) to cephalofortuneine (II), it was found, in dilute acetic acid and 0 癈, I could react with bromine in CCl4(1:10) directly to get 2-O-acetylcephalofortuneine and its 2-C epimer in ratio (9:1). The yield depends on reaction temperature

Key words: BROMINE, CARBON TETRACHLORIDE, PROTON MAGNETIC RESONANCE SPECTROMETRY, CEPHALOTOXINUM, ACETIC ACID, STEREOSELECTIVITY, CEPHALOTAXUS FORTUNEI

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